Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

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Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

PPARγ and the global map of adipogenesis and beyond

(2014) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Transcription Factor Cooperativity in Early Adipogenic Hotspots and Super-Enhancers

(2014) Rasmus Siersbæk et al.   Cell Reports

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

Krüppel-like Factor 11 Regulates the Expression of Metabolic Genes via an Evolutionarily Conserved Protein Interaction Domain Functionally Disrupted in Maturity Onset Diabetes of the Young

(2013) Gwen Lomberk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute Genome-Wide Effects of Rosiglitazone on PPARγ Transcriptional Networks in Adipocytes

(2013) Anders Kristian Haakonsson et al.   MOLECULAR ENDOCRINOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

(2013) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Fat cells directly sense temperature to activate thermogenesis

(2013) L. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Role of kruppel-like transcription factors in adipogenesis

(2012) Zeni Wu et al.   DEVELOPMENTAL BIOLOGY

Krüppel-like Factor 11 Differentially Couples to Histone Acetyltransferase and Histone Methyltransferase Chromatin Remodeling Pathways to Transcriptionally Regulate Dopamine D2 Receptor in Neuronal Cells

(2012) Seungmae Seo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence-specific Recruitment of Heterochromatin Protein 1 via Interaction with Krüppel-like Factor 11, a Human Transcription Factor Involved in Tumor Suppression and Metabolic Diseases

(2012) Gwen Lomberk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse KLF11 regulates hepatic lipid metabolism

(2012) Huabing Zhang et al.   JOURNAL OF HEPATOLOGY

Genome-Wide Profiling of Peroxisome Proliferator-Activated Receptor   in Primary Epididymal, Inguinal, and Brown Adipocytes Reveals Depot-Selective Binding Correlated with Gene Expression

(2012) M. S. Siersbaek et al.   MOLECULAR AND CELLULAR BIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation

(2011) A. M. Pilon et al.   BLOOD

Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites

(2011) Søren F Schmidt et al.   BMC GENOMICS

Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis

(2011) Rasmus Siersbaek et al.   EMBO JOURNAL

Disruption of a Novel Krüppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331INSMutation Found in Neonatal Diabetes Mellitus

(2011) Amélie Bonnefond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Species-Specific Strategies Underlying Conserved Functions of Metabolic Transcription Factors

(2011) Raymond E. Soccio et al.   MOLECULAR ENDOCRINOLOGY

Global Mapping of Cell Type–Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation

(2011) Hironori Waki et al.   PLoS Genetics

Differentiation of human adipose-derived stem cells into “brite” (brown-in-white) adipocytes

(2011) Didier F. Pisani   Frontiers in Endocrinology

Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15

(2010) Ken-ichi Yamamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparative Epigenomic Analysis of Murine and Human Adipogenesis

(2010) Tarjei S. Mikkelsen et al.   CELL

Propagation of adipogenic signals through an epigenomic transition state

(2010) D. J. Steger et al.   GENES & DEVELOPMENT

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

A unique chromatin signature uncovers early developmental enhancers in humans

(2010) Alvaro Rada-Iglesias et al.   NATURE

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beige Can Be Slimming

(2010) J. Ishibashi et al.   SCIENCE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

MODY7Gene,KLF11, Is a Novel p300-dependent Regulator ofPdx-1(MODY4) Transcription in Pancreatic Islet β Cells

(2009) Martin E. Fernandez-Zapico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone modifications at human enhancers reflect global cell-type-specific gene expression

(2009) Nathaniel D. Heintzman et al.   NATURE

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes

(2009) Christian Elabd et al.   STEM CELLS

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Genome-wide profiling of PPAR :RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

(2008) R. Nielsen et al.   GENES & DEVELOPMENT

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT