An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

FVIIa as used pharmacologically is not TF dependent in hemophilia B mice

(2014) D. Feng et al.   BLOOD

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prolonged effect of a new O-glycoPEGylated FVIII (N8-GP) in a murine saphenous vein bleeding model

(2013) A. E. Pastoft et al.   HAEMOPHILIA

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

(2013) Kevin Fitzgerald et al.   LANCET

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate®)

(2012) A. E. PASTOFT et al.   HAEMOPHILIA

A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia

(2011) Lacramioara Ivanciu et al.   NATURE BIOTECHNOLOGY

Phosphatidylinositol Containing Lipidic Particles Reduces Immunogenicity and Catabolism of Factor VIII in Hemophilia A Mice

(2010) Aaron Peng et al.   AAPS Journal

Inherited antithrombin deficiency: a review

(2010) M. M. PATNAIK et al.   HAEMOPHILIA

Severe hemophilia with mild bleeding phenotype: molecular characterization and global coagulation profile

(2010) E. SANTAGOSTINO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Heterozygous antithrombin deficiency improves in vivo haemostasis in factor VIII-deficient mice

(2010) Daniel Bolliger et al.   THROMBOSIS AND HAEMOSTASIS

Interpatient Phenotypic Inconsistency in Severe Congenital Hemophilia: A Systematic Review of the Role of Inherited Thrombophilia

(2009) Massimo Franchini et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Factor V Leiden and hemophilia

(2009) Massimo Franchini et al.   THROMBOSIS RESEARCH

The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis

(2008) Y. Buyue et al.   BLOOD