DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides

Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

(2016) Tatiana Kent et al.   eLife

Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors

(2015) Christopher J. Lord et al.   Annual Review of Medicine

Evolution of Functional Six-Nucleotide DNA

(2015) Liqin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients

(2015)   Oncotarget

A semi-synthetic organism with an expanded genetic alphabet

(2014) Denis A. Malyshev et al.   NATURE

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

DNA polymerases drive DNA sequencing-by-synthesis technologies: both past and present

(2014) Cheng-Yao Chen   Frontiers in Microbiology

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C

(2013) Edward J. Gane et al.   NEW ENGLAND JOURNAL OF MEDICINE

KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry

(2012) Karin Betz et al.   Nature Chemical Biology

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics

(2012) J. J. Foti et al.   SCIENCE

Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks

(2012) Xiao-Jun Liu et al.   Chinese Journal of Cancer

DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients

(2012) C Allera-Moreau et al.   Oncogenesis

Human Mitochondrial DNA Polymerase γ Exhibits Potential for Bypass and Mutagenesis at UV-induced Cyclobutane Thymine Dimers

(2011) Rajesh Kasiviswanathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Encoding Phenotype in Bacteria with an Alternative Genetic Set

(2011) Andrew T. Krueger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly specific unnatural base pair systems as a third base pair for PCR amplification

(2011) Rie Yamashige et al.   NUCLEIC ACIDS RESEARCH

Promiscuous DNA synthesis by human DNA polymerase θ

(2011) Matthew Hogg et al.   NUCLEIC ACIDS RESEARCH

A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown

(2010) Geoff S. Higgins et al.   CANCER RESEARCH

Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts

(2010) Matthew Hogg et al.   JOURNAL OF MOLECULAR BIOLOGY

Fluorescent xDNA nucleotides as efficient substrates for a template-independent polymerase

(2010) Sarah K. Jarchow-Choy et al.   NUCLEIC ACIDS RESEARCH

Toward a designed genetic system with biochemical function: polymerase synthesis of single and multiple size-expanded DNA base pairs

(2010) Haige Lu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

DNA polymerase   up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

(2010) F. Lemee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Replication Bypass of Size-Expanded DNA Base Pairs in Bacterial Cells

(2009) James C. Delaney et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA polymerase Family X: Function, structure, and cellular roles

(2009) Jennifer Yamtich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Critical amino acids in human DNA polymerases η and κ involved in erroneous incorporation of oxidized nucleotides

(2009) Atsushi Katafuchi et al.   NUCLEIC ACIDS RESEARCH

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

(2008) Scott D McCulloch et al.   CELL RESEARCH

Fluorescence of Size-Expanded DNA Bases:  Reporting on DNA Sequence and Structure with an Unnatural Genetic Set

(2008) Andrew T. Krueger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Low-fidelity DNA synthesis by human DNA polymerase theta

(2008) M. E. Arana et al.   NUCLEIC ACIDS RESEARCH

Four-color DNA sequencing with 3'-O-modified nucleotide reversible terminators and chemically cleavable fluorescent dideoxynucleotides

(2008) J. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymerase θ (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct

(2007) Mineaki Seki et al.   DNA REPAIR