Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis

Primary Progressive Multiple Sclerosis Evolving From Radiologically Isolated Syndrome

(2015) Orhun H. Kantarci et al.   ANNALS OF NEUROLOGY

Statin Treatment in Multiple Sclerosis: A Systematic Review and Meta-Analysis

(2015) Gorm Pihl-Jensen et al.   CNS DRUGS

Progressive multiple sclerosis

(2015) Daniel Ontaneda et al.   CURRENT OPINION IN NEUROLOGY

The crucial role of mast cells in blood–brain barrier alterations

(2015) Domenico Ribatti   EXPERIMENTAL CELL RESEARCH

Prolactin in combination with interferon-β reduces disease severity in an animal model of multiple sclerosis

(2015) Simon Zhornitsky et al.   Journal of Neuroinflammation

A much-needed focus on progression in multiple sclerosis

(2015) Alan J Thompson   LANCET NEUROLOGY

Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives

(2015) Daniel Ontaneda et al.   LANCET NEUROLOGY

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Treatment of progressive multiple sclerosis: what works, what does not, and what is needed

(2015) Anthony Feinstein et al.   LANCET NEUROLOGY

Multiple sclerosis—a quiet revolution

(2015) Richard M. Ransohoff et al.   Nature Reviews Neurology

“Disease modifying nutricals” for multiple sclerosis

(2015) Katja Schmitz et al.   PHARMACOLOGY & THERAPEUTICS

High-Dose Immunosuppressive Therapy and Autologous Hematopoietic Cell Transplantation for Relapsing-Remitting Multiple Sclerosis (HALT-MS)

(2015) Richard A. Nash et al.   JAMA Neurology

High doses of biotin in chronic progressive multiple sclerosis: A pilot study

(2015) Frédéric Sedel et al.   Multiple Sclerosis and Related Disorders

Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis

(2015) Hanna M. Vesterinen et al.   PLoS One

Intrathecal Rituximab Therapy in Multiple Sclerosis: Review of Evidence Supporting the Need for Future Trials

(2014) Mickael Bonnan et al.   CURRENT DRUG TARGETS

Autologous Bone Marrow Transplantation for the Treatment of Multiple Sclerosis

(2014) Marta Radaelli et al.   Current Neurology and Neuroscience Reports

Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?

(2014) Sausan Jaber et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis

(2014) P. De Sarno et al.   JOURNAL OF IMMUNOLOGY

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

Relapses and disability accumulation in progressive multiple sclerosis

(2014) M. M. Paz Soldan et al.   NEUROLOGY

Natalizumab in progressive MS: Results of an open-label, phase 2A, proof-of-concept trial

(2014) J. Romme Christensen et al.   NEUROLOGY

Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity

(2014) P. Browne et al.   NEUROLOGY

Defining the clinical course of multiple sclerosis: The 2013 revisions

(2014) F. D. Lublin et al.   NEUROLOGY

Neurological deficits caused by tissue hypoxia in neuroinflammatory disease

(2013) Andrew L. Davies et al.   ANNALS OF NEUROLOGY

Iron and neurodegeneration in the multiple sclerosis brain

(2013) Simon Hametner et al.   ANNALS OF NEUROLOGY

Disease-specific molecular events in cortical multiple sclerosis lesions

(2013) Marie Therese Fischer et al.   BRAIN

Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis

(2013) Damineh Morsali et al.   BRAIN

Monoclonal antibodies in treatment of multiple sclerosis

(2013) P. S. Rommer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Challenges in multiple sclerosis; how to define occurence of progression

(2013) V.V. Brinar et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Novel immunoregulatory properties of EGCG on reducing inflammation in EAE

(2013) Hong Nie   Frontiers in Bioscience-Landmark

The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse

(2013) Sebastian M. Fiebiger et al.   JOURNAL OF NEUROIMMUNOLOGY

Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study

(2013) Krzysztof Selmaj et al.   LANCET NEUROLOGY

Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial

(2013) John Zajicek et al.   LANCET NEUROLOGY

A comparative study of CSF neurofilament light and heavy chain protein in MS

(2013) Jens Kuhle et al.   Multiple Sclerosis Journal

Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions

(2013) Corinne Brana et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neuroprotection for acute optic neuritis—Can it work?

(2013) R.E. Raftopoulos et al.   Multiple Sclerosis and Related Disorders

Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study

(2012) Patrick Vermersch et al.   BMC Neurology

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

(2012) Sung R. Choi et al.   BRAIN

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

(2012) Peter Connick et al.   LANCET NEUROLOGY

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

(2012) Robert J Fox et al.   Multiple Sclerosis Journal

Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis

(2012) B. G. Arnason et al.   Multiple Sclerosis Journal

Prolactin in multiple sclerosis

(2012) Simon Zhornitsky et al.   Multiple Sclerosis Journal

Biotin-responsive basal ganglia disease revisited: Clinical, radiologic, and genetic findings

(2012) B. Tabarki et al.   NEUROLOGY

Adaptive trial designs: a review of barriers and opportunities

(2012) John A Kairalla et al.   Trials

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

(2011) Sandra Vergo et al.   BRAIN

Treatment of Infantile Spasms

(2011) Carl E. Stafstrom et al.   JOURNAL OF CHILD NEUROLOGY

A randomized clinical trial of autologous T-cell therapy in multiple sclerosis: subset analysis and implications for trial design

(2011) Edward Fox et al.   Multiple Sclerosis Journal

Long-term results of stem cell transplantation for MS: A single-center experience

(2011) A. Fassas et al.   NEUROLOGY

Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS

(2011) M. C. Kowarik et al.   NEUROLOGY

Age and disability accumulation in multiple sclerosis

(2011) A. Scalfari et al.   NEUROLOGY

The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators

(2011) B. Soliven et al.   NEUROLOGY

A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS

(2011) M. S. Freedman et al.   NEUROLOGY

Fluoxetine protects neurons against microglial activation-mediated neurotoxicity

(2011) Feng Zhang et al.   PARKINSONISM & RELATED DISORDERS

Riluzole, Neuroprotection and Amyotrophic Lateral Sclerosis

(2010) B.C. Cheah et al.   CURRENT MEDICINAL CHEMISTRY

Characterization of brain lesions in a mouse model of progressive multiple sclerosis

(2010) H. Levy et al.   EXPERIMENTAL NEUROLOGY

Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial

(2010) Raju Kapoor et al.   LANCET NEUROLOGY

A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis

(2010) Jeremy Chataway et al.   Multiple Sclerosis Journal

Ibudilast in relapsing-remitting multiple sclerosis: A neuroprotectant?

(2010) F. Barkhof et al.   NEUROLOGY

Biomarker-adaptive clinical trial designs

(2010) Boris Freidlin et al.   PHARMACOGENOMICS

MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity

(2010) Rebecca C. Girvan et al.   VACCINE

Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial

(2009) Kathleen Hawker et al.   ANNALS OF NEUROLOGY

Human Mast Cells Stimulate Activated T Cells

(2009) Theoharis C. Theoharides et al.   Annals of the New York Academy of Sciences

Autologous T-Cell Vaccination for Multiple Sclerosis

(2009) Arthur A Vandenbark et al.   BIODRUGS

Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis

(2009) M. Kolappan et al.   JOURNAL OF NEUROLOGY

Prospects of repair in multiple sclerosis

(2009) V. Wee Yong   JOURNAL OF THE NEUROLOGICAL SCIENCES

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

(2009) Patrice Dubreuil et al.   PLoS One

Statins: Mechanisms of neuroprotection

(2009) Peter J. van der Most et al.   PROGRESS IN NEUROBIOLOGY

Multi-Arm Clinical Trials of New Agents: Some Design Considerations

(2008) B. Freidlin et al.   CLINICAL CANCER RESEARCH

LINGO-1 antagonists as therapy for multiple sclerosis:in vitroandin vivoevidence

(2008) Richard A Rudick et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

DNA-based vaccines: the future of multiple sclerosis therapy?

(2008) Olaf Stüve et al.   Expert Review of Neurotherapeutics

Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect

(2008) Chae-Moon Lim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Prolactin and dopamine: What is the connection? A Review Article

(2008) Peter Fitzgerald et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Getting specific: monoclonal antibodies in multiple sclerosis

(2008) Andreas Lutterotti et al.   LANCET NEUROLOGY

Neuroprotective actions of melanocortins: a therapeutic opportunity

(2008) Anna Catania   TRENDS IN NEUROSCIENCES

Review: Recombinant human erythropoietin: novel strategies for neuroprotective/neuroregenerative treatment of multiple sclerosis

(2008) Claudia Bartels et al.   Therapeutic Advances in Neurological Disorders

Lipoic Acid: A Novel Therapeutic Approach for Multiple Sclerosis and Other Chronic Inflammatory Diseases of the CNS

(2008) Sonemany Salinthone et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis

(2007) Arthur A. Vandenbark et al.   IMMUNOLOGY