Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation

Neutrophils discriminate live from dead bacteria by integrating signals initiated by Fprs and TLRs

(2022) Germana Lentini et al.   EMBO JOURNAL

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

(2021) Ricardo Grieshaber-Bouyer et al.   Nature Communications

Role of Endosomal TLRs in Staphylococcus aureus Infection

(2021) Germana Lentini et al.   JOURNAL OF IMMUNOLOGY

Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections

(2021) Martin P. Alphonse et al.   Science Translational Medicine

Dying cells fan the flames of inflammation

(2021) Kim Newton et al.   SCIENCE

Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci

(2020) Agata Famà et al.   mBio

Multiple roles of caspase‐8 in cell death, inflammation, and innate immunity

(2020) Pontus Orning et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons

(2019) Brian P. Daniels et al.   IMMUNITY

The dual role of innate immunity during influenza

(2019) Carmelo Biondo et al.   Biomedical Journal

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

(2019) Snahel Patel et al.   CELL DEATH AND DIFFERENTIATION

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against Toxoplasma gondii

(2019) Alexandra A. DeLaney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation

(2019) Kim Newton   Cold Spring Harbor Perspectives in Biology

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production

(2019) Germana Lentini et al.   JOURNAL OF IMMUNOLOGY

Caspase selective reagents for diagnosing apoptotic mechanisms

(2018) Marcin Poreba et al.   CELL DEATH AND DIFFERENTIATION

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

(2018) Pratyusha Mandal et al.   IMMUNITY

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

(2018) Anna S. Lehle et al.   GASTROENTEROLOGY

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide

(2017) Danish Saleh et al.   JOURNAL OF IMMUNOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

Necroptosis-independent signaling by the RIP kinases in inflammation

(2016) Kenta Moriwaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4

(2016) Malek Najjar et al.   IMMUNITY

Understanding the mechanisms and drivers of antimicrobial resistance

(2016) Alison H Holmes et al.   LANCET

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

(2016) Naomi H. Philip et al.   PLoS Pathogens

Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection

(2016) Nastaran Mohammadi et al.   PLoS One

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

(2014) R. Allam et al.   EMBO REPORTS

Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways

(2014) Claudia Günther et al.   GUT

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair

(2014) Kenta Moriwaki et al.   IMMUNITY

The Interleukin-1β/CXCL1/2/Neutrophil Axis Mediates Host Protection against Group B Streptococcal Infection

(2014) C. Biondo et al.   INFECTION AND IMMUNITY

Role of Toll-Like Receptor 13 in Innate Immune Recognition of Group B Streptococci

(2014) Giacomo Signorino et al.   INFECTION AND IMMUNITY

Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen,Candida albicans

(2014) Sandhya Ganesan et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease

(2014) Sybille Landwehr-Kenzel et al.   Frontiers in Immunology

Neutrophil-Derived Cytokines: Facts Beyond Expression

(2014) Cristina Tecchio et al.   Frontiers in Immunology

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1  Production

(2013) S. M. Man et al.   JOURNAL OF IMMUNOLOGY

Ensuring Animal Welfare While Meeting Scientific Aims Using a Murine Pneumonia Model of Septic Shock

(2013) Olivier Huet et al.   SHOCK

Caspase Substrates and Inhibitors

(2013) M. Poreba et al.   Cold Spring Harbor Perspectives in Biology

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Activation of the NLRP3 Inflammasome by Group B Streptococci

(2012) A. Costa et al.   JOURNAL OF IMMUNOLOGY

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

(2009) Andrew Kovalenko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity

(2008) Natasha Ann Pereira et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neutrophil serine proteases fine-tune the inflammatory response

(2007) C PHAM   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY