A designer peptide against the EAG2–Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma

Neurons as stromal drivers of nervous system cancer formation and progression

(2023) Corina Anastasaki et al.   DEVELOPMENTAL CELL

Key Clinical Principles in the Management of Glioblastoma

(2023) Rupesh Kotecha et al.   JCO Oncology Practice

Cancer neuroscience: State of the field, emerging directions

(2023) Frank Winkler et al.   CELL

Glioblastoma remodelling of human neural circuits decreases survival

(2023) Saritha Krishna et al.   NATURE

Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation

(2023) Rachel Naomi Curry et al.   NEURON

Olfactory sensory experience regulates gliomagenesis via neuronal IGF1

(2022) Pengxiang Chen et al.   NATURE

Glioma progression is shaped by genetic evolution and microenvironment interactions

(2022) Frederick S. Varn et al.   CELL

A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours

(2022) Akram A. Hamed et al.   Nature Communications

Perspective of mesenchymal transformation in glioblastoma

(2021) Yona Kim et al.   Acta Neuropathologica Communications

NF1 mutation drives neuronal activity-dependent initiation of optic glioma

(2021) Yuan Pan et al.   NATURE

Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth

(2020) Michelle A. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

(2020) Kwanha Yu et al.   NATURE

Roadmap for the Emerging Field of Cancer Neuroscience

(2020) Michelle Monje et al.   CELL

The +TIP Navigator-1 is an actin–microtubule crosslinker that regulates axonal growth cone motility

(2020) Carlos Sánchez-Huertas et al.   JOURNAL OF CELL BIOLOGY

Synaptic input to brain tumors: clinical implications

(2020) Varun Venkataramani et al.   NEURO-ONCOLOGY

Inhibition of intermedin (adrenomedullin 2) suppresses the growth of glioblastoma and increases the antitumor activity of temozolomide

(2020) Luping Huang et al.   MOLECULAR CANCER THERAPEUTICS

Involvement of N-methylpurine DNA glycosylase in resistance to temozolomide in patient-derived glioma cells

(2020) Gemma Serrano-Heras et al.   Scientific Reports

The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met

(2019) Claire Emma McGregor et al.   Frontiers in Cellular Neuroscience

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Synaptic proximity enables NMDAR signalling to promote brain metastasis

(2019) Qiqun Zeng et al.   NATURE

An anatomic transcriptional atlas of human glioblastoma

(2018) Ralph B. Puchalski et al.   SCIENCE

LGALS3 promotes treatment resistance in glioblastoma and is associated with tumor risk and prognosis

(2018) Hongxiang Wang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Ion channels as therapeutic antibody targets

(2018) Catherine J. Hutchings et al.   mAbs

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells

(2017) Elisa Venturini et al.   NEUROSIGNALS

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

(2016) Sonam Dolma et al.   CANCER CELL

Suppression of the Eag1 potassium channel sensitizes glioblastoma cells to injury caused by temozolomide

(2016) Thais Torquato Sales et al.   Oncology Letters

Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment

(2015) Hinke F. van Thuijl et al.   ACTA NEUROPATHOLOGICA

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target

(2015) Xi Huang et al.   NATURE NEUROSCIENCE

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-density Lipoprotein Receptor-related Protein 1 (LRP1)-dependent Cell Signaling Promotes Axonal Regeneration

(2013) Choya Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

(2013) B. E. Johnson et al.   SCIENCE

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics

(2012) X. Huang et al.   GENES & DEVELOPMENT

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

(2012) Sharan K. Bagal et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Translational Paradigm for the Preclinical Evaluation of the Stroke Neuroprotectant Tat-NR2B9c in Gyrencephalic Nonhuman Primates

(2012) D. J. Cook et al.   Science Translational Medicine

EphA4 Blockers Promote Axonal Regeneration and Functional Recovery Following Spinal Cord Injury in Mice

(2011) Yona Goldshmit et al.   PLoS One

VEGF in the nervous system

(2011) Jeffrey M. Rosenstein et al.   Organogenesis

Ancillary Subunits Associated With Voltage-Dependent K+ Channels

(2010) Olaf Pongs et al.   PHYSIOLOGICAL REVIEWS

Cortisone dissociates the Shaker family K+ channels from their β subunits

(2008) Yaping Pan et al.   Nature Chemical Biology

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo

(2008) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA