Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs

Biosynthesis of Epimers C2 and C2a in the Gentamicin C Complex

(2015) Yawen Gu et al.   CHEMBIOCHEM

Epimerization at C-3′′ in Butirosin Biosynthesis by an NAD+-Dependent Dehydrogenase BtrE and an NADPH-Dependent Reductase BtrF

(2015) Ryohei Takeishi et al.   CHEMBIOCHEM

Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex

(2015) Chuan Huang et al.   CHEMISTRY & BIOLOGY

Designer aminoglycosides prevent cochlear hair cell loss and hearing loss

(2015) Markus E. Huth et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure–Activity Relationships for Antibacterial to Antifungal Conversion of Kanamycin to Amphiphilic Analogues

(2015) Marina Fosso et al.   JOURNAL OF ORGANIC CHEMISTRY

Consecutive radicalS-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

(2015) Daniel R. Marous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis

(2014) Junhong Guo et al.   CHEMISTRY & BIOLOGY

Mechanistic Diversity of RadicalS-Adenosylmethionine (SAM)-dependent Methylation

(2014) Matthew R. Bauerle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis

(2014) Fumitaka Kudo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antifungal amphiphilic aminoglycosides

(2014) C.-W. T. Chang et al.   MedChemComm

Natural Products and Synthetic Biology

(2014) Mohammad R. Seyedsayamdost et al.   ACS Synthetic Biology

Structure-Guided Discovery of a Novel Aminoglycoside Conjugate Targeting HIV-1 RNA Viral Genome

(2013) Eric Ennifar et al.   ACS Chemical Biology

Designer Aminoglycosides That Selectively Inhibit Cytoplasmic Rather than Mitochondrial Ribosomes Show Decreased Ototoxicity

(2013) Eli Shulman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro read-through of phenylalanine hydroxylase (PAH) nonsense mutations using aminoglycosides: a potential therapy for phenylketonuria

(2013) Gladys Ho et al.   JOURNAL OF INHERITED METABOLIC DISEASE

GenK-Catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-Dependent Radical SAM Enzyme

(2013) Hak Joong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry

(2013) P. J. Goldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aminoglycoside Antibiotics in the 21st Century

(2012) Bernd Becker et al.   ACS Chemical Biology

The Last Step of Kanamycin Biosynthesis: Unique Deamination Reaction Catalyzed by the α-Ketoglutarate-Dependent Nonheme Iron Dioxygenase KanJ and the NADPH-Dependent Reductase KanK

(2012) Hilda Sucipto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Peptide Nucleic Acid–Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits Tat-Mediated Transactivation of HIV-1 Transcription

(2012) Indrajit Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

(2012) T. Matt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

New developments in aminoglycoside therapy and ototoxicity

(2011) Jing Xie et al.   HEARING RESEARCH

The oxidoreductases LivQ and NeoQ are responsible for the different 6′-modifications in the aminoglycosides lividomycin and neomycin

(2011) D. Clausnitzer et al.   JOURNAL OF APPLIED MICROBIOLOGY

Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation

(2011) Je Won Park et al.   Nature Chemical Biology

Construction of kanamycin B overproducing strain by genetic engineering of Streptomyces tenebrarius

(2010) Xianpu Ni et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Future of Aminoglycosides: The End or Renaissance?

(2010) Jacob L. Houghton  et al.   CHEMBIOCHEM

Beyond directed evolution—semi-rational protein engineering and design

(2010) Stefan Lutz   CURRENT OPINION IN BIOTECHNOLOGY

Aminoglycoside modifying enzymes

(2010) Maria S. Ramirez et al.   DRUG RESISTANCE UPDATES

The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review

(2010) Heinz G Floss et al.   JOURNAL OF ANTIBIOTICS

Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster

(2009) Fumitaka Kudo et al.   JOURNAL OF ANTIBIOTICS

Enzymatic preparation of neomycin C from ribostamycin

(2009) Fumitaka Kudo et al.   JOURNAL OF ANTIBIOTICS

Biosynthetic genes for aminoglycoside antibiotics

(2009) Fumitaka Kudo et al.   JOURNAL OF ANTIBIOTICS

Characterization and Mechanistic Studies of DesII: A RadicalS-Adenosyl-l-methionine Enzyme Involved in the Biosynthesis of TDP-d-Desosamine

(2009) Ping-Hui Szu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Study on the Reaction of a Radical SAM Dehydrogenase BtrN by Electron Paramagnetic Resonance Spectroscopy†

(2008) Kenichi Yokoyama et al.   BIOCHEMISTRY

Structure–toxicity relationship of aminoglycosides: Correlation of 2′-amine basicity with acute toxicity in pseudo-disaccharide scaffolds

(2008) Lilach Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Involvement of Two DistinctN-Acetylglucosaminyltransferases and a Dual-Function Deacetylase in Neomycin Biosynthesis

(2008) Kenichi Yokoyama et al.   CHEMBIOCHEM

Chemoenzymatic acylation of aminoglycoside antibiotics

(2008) Nicholas M. Llewellyn et al.   CHEMICAL COMMUNICATIONS

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Insight into the mechanisms of aminoglycoside derivatives interaction with HIV-1 entry steps and viral gene transcription

(2008) Aviva Lapidot et al.   FEBS Journal

Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set

(2008) J. W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity

(2008) S. N. Hobbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases

(2007) Mariana Hainrichson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY