Osteoporosis in Adrenal Insufficiency: Could Metformin be Protective?

Association of metformin use with fracture risk in type 2 diabetes: A systematic review and meta-analysis of observational studies

(2023) Yining Wang et al.   Frontiers in Endocrinology

The use of metformin, sulfonylurea compounds and insulin and the risk of hip fractures in diabetic patients: a systematic review and meta-analysis of observational studies

(2023) Mansour Bahardoust et al.   BMC MUSCULOSKELETAL DISORDERS

Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice

(2023) Yuqi Guo et al.   eLife

Metformin alleviates dexamethasone-induced apoptosis by regulating autophagy via AMPK/mTOR/p70S6K in osteoblasts

(2022) Xintong Guo et al.   EXPERIMENTAL CELL RESEARCH

Metformin and the heart: Update on mechanisms of cardiovascular protection with special reference to comorbid type 2 diabetes and heart failure

(2022) Guntram Schernthaner et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Advanced glycation end products promote osteoporosis by inducing ferroptosis in osteoblasts

(2022) Weiwei Ge et al.   Molecular Medicine Reports

Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions

(2022) Jia-Xu Li et al.   Nature Reviews Endocrinology

New Insights into the Role of Insulin and Hypothalamic-Pituitary-Adrenal (HPA) Axis in the Metabolic Syndrome

(2022) Joseph A. M. J. L. Janssen   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin activates Wnt/β-catenin for the treatment of diabetic osteoporosis

(2022) Xiaopeng Huang et al.   BMC Endocrine Disorders

Metformin Facilitates Osteoblastic Differentiation and M2 Macrophage Polarization by PI3K/AKT/mTOR Pathway in Human Umbilical Cord Mesenchymal Stem Cells

(2022) Min Shen et al.   Stem Cells International

Roles of osteoprotegerin in endocrine and metabolic disorders through receptor activator of nuclear factor kappa-B ligand/receptor activator of nuclear factor kappa-B signaling

(2022) Luodan Zhang et al.   Frontiers in Cell and Developmental Biology

Adrenal insufficiency

(2021) Stefanie Hahner et al.   Nature Reviews Disease Primers

Prolonged proliferation and delayed senescence of the adipose-derived stem cells grown on the electrospun composite nanofiber co-encapsulated with TiO2 nanoparticles and metformin-loaded mesoporous silica nanoparticles

(2021) Raheleh Pourpirali et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition

(2021) Francisco Arrieta et al.   Nutrients

Clinical Unmet Needs in the Treatment of Adrenal Crisis: Importance of the Patient’s Perspective

(2021) Kim M. J. A. Claessen et al.   Frontiers in Endocrinology

Efficient osteoblastic differentiation of human adipose-derived stem cells on TiO2 nanoparticles and metformin co-embedded electrospun composite nanofibers

(2021) Somayeh Ahmadi et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway

(2021) Haohui Guo et al.   PLoS One

Metformin and Bone Metabolism in Endogenous Glucocorticoid Excess: An Exploratory Study

(2021) Frederick Vogel et al.   Frontiers in Endocrinology

Metformin use is associated with a lower risk of osteoporosis in adult women independent of type 2 diabetes mellitus and obesity. REDLINC IX study

(2020) Juan E. Blümel et al.   GYNECOLOGICAL ENDOCRINOLOGY

Metformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial

(2020) Ida Pernicova et al.   Lancet Diabetes & Endocrinology

Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment

(2020) Pojchong Chotiyarnwong et al.   Nature Reviews Endocrinology

Metformin and Its Benefits for Various Diseases

(2020) Ziquan Lv et al.   Frontiers in Endocrinology

Glucocorticoid-induced osteoporosis: Insights for the clinician

(2020) Shakaib Hayat et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Metformin inhibits the activation of melanocortin receptors 2 and 3 in vitro: A possible mechanism for its anti-androgenic and weight balancing effects in vivo?

(2020) Shaheena Parween et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study

(2020) Katherine Samaras et al.   DIABETES CARE

Metformin inhibits inflammation and bone destruction in collagen- induced arthritis in rats

(2020) Kai-Jian Fan et al.   Annals of Translational Medicine

Metformin use and risk of fracture: a systematic review and meta-analysis of observational studies

(2019) A. Salari-Moghaddam et al.   OSTEOPOROSIS INTERNATIONAL

Preventative effects of metformin on glucocorticoid-induced osteoporosis in rats

(2019) Jianrong Zhao et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy

(2018) Rowan S Hardy et al.   ENDOCRINE REVIEWS

Metformin; an old antidiabetic drug with new potentials in bone disorders

(2018) Saman Bahrambeigi et al.   BIOMEDICINE & PHARMACOTHERAPY

Higher glucocorticoid replacement doses are associated with increased mortality in patients with pituitary adenoma

(2017) Casper Hammarstrand et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The effect of insulin on bone mineral density among women with type 2 diabetes: a SWAN Pharmacoepidemiology study

(2017) K. Ruppert et al.   OSTEOPOROSIS INTERNATIONAL

Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency

(2016) Julia Schulz et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

MECHANISMS IN ENDOCRINOLOGY: Endogenous subclinical hypercortisolism and bone: a clinical review

(2016) I Chiodini et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Glucocorticoid Signaling and Bone Biology

(2016) T. Komori   HORMONE AND METABOLIC RESEARCH

Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus

(2016) Anna J. Anderson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline

(2016) Stefan R. Bornstein et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of metformin treatment on circulating osteoprotegerin in patients with nonalcoholic fatty liver disease

(2015) Elena Sofer et al.   Hepatology International

Diagnosis and management of adrenal insufficiency

(2015) Irina Bancos et al.   Lancet Diabetes & Endocrinology

Adrenal insufficiency

(2014) Evangelia Charmandari et al.   LANCET

Endogenous Glucocorticoids and Bone

(2014) Hong Zhou et al.   Bone Research

Protective Effect of Metformin on Periapical Lesions in Rats by Decreasing the Ratio of Receptor Activator of Nuclear Factor Kappa B Ligand/Osteoprotegerin

(2012) Lingshuang Liu et al.   JOURNAL OF ENDODONTICS

Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats

(2011) Qi-Guang Mai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bone Mineral Density Is Not Significantly Reduced in Adult Patients on Low-Dose Glucocorticoid Replacement Therapy

(2011) K. R. Koetz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

AMP-activated protein kinase pathway and bone metabolism

(2011) J Jeyabalan et al.   JOURNAL OF ENDOCRINOLOGY

Adrenal gland and bone

(2010) Rowan Hardy et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Glucocorticoid-Induced Hyperglycemia

(2009) John Clore et al.   Endocrine Practice

Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease: effects on bone

(2009) Kristian Løvås et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Effect of metformin on bone marrow progenitor cell differentiation: In vivo and in vitro studies

(2009) M Silvina Molinuevo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Metformin reverses the deleterious effects of high glucose on osteoblast function

(2009) Donghu Zhen et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS