Snail and kidney fibrosis

Egr-1 Mediates Chronic Hypoxia-Induced Renal Interstitial Fibrosis via the PKC/ERK Pathway

(2017) Shiren Sun et al.   AMERICAN JOURNAL OF NEPHROLOGY

TNF-related weak inducer of apoptosis (TWEAK) regulates junctional proteins in tubular epithelial cells via canonical NF-κB pathway and ERK activation

(2015) Sergio Berzal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epigenetic Modulation of Human Podocyte Vitamin D Receptor in HIV Milieu

(2015) Nirupama Chandel et al.   JOURNAL OF MOLECULAR BIOLOGY

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial–mesenchymal transition and renal fibrosis in diabetic nephropathy

(2015) Qian Lu et al.   PHARMACOLOGICAL RESEARCH

Akt2 Mediates TGF-�1-Induced Epithelial to Mesenchymal Transition by Deactivating GSK3�/Snail Signaling Pathway in Renal Tubular Epithelial Cells

(2014) Aiping Lan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Epidermal growth factor inhibits transforming growth factor-β-induced fibrogenic differentiation marker expression through ERK activation

(2014) Xiaoying Liu et al.   CELLULAR SIGNALLING

Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT

(2014) Antonio Díaz-López et al.   INTERNATIONAL JOURNAL OF CANCER

Integrative Biology Identifies Shared Transcriptional Networks in CKD

(2014) S. Martini et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy

(2014) Jin-Yang Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hypoxia-induced Bmi1 promotes renal tubular epithelial cell–mesenchymal transition and renal fibrosis via PI3K/Akt signal

(2014) Rui Du et al.   MOLECULAR BIOLOGY OF THE CELL

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-328 Inhibits Renal Tubular Cell Epithelial-to-Mesenchymal Transition by Targeting the CD44 in Pressure-Induced Renal Fibrosis

(2014) Cheng-Hsien Chen et al.   PLoS One

Akt2 Is Involved in Loss of Epithelial Cells and Renal Fibrosis following Unilateral Ureteral Obstruction

(2014) Aiping Lan et al.   PLoS One

Protein Kinase C-Induced Early Growth Response Protein-1 Binding to SNAIL Promoter in Epithelial–Mesenchymal Transition of Human Embryonic Stem Cells

(2014) Masaki Kinehara et al.   STEM CELLS AND DEVELOPMENT

Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells

(2014) K Fujiki et al.   Cell Death & Disease

Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury

(2013) Hee-Seong Jang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

EMT–MET in renal disease: Should we curb our enthusiasm?

(2013) Pierre Galichon et al.   CANCER LETTERS

Epidermal growth factor promotes transforming growth factor-β1-induced epithelial-mesenchymal transition in HK-2 cells through a synergistic effect on Snail

(2013) Jun Xiong et al.   MOLECULAR BIOLOGY REPORTS

Expression of the transcriptional regulator snail1 in kidney transplants displaying epithelial-to-mesenchymal transition features

(2013) Yi-Chun Xu-Dubois et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells

(2012) Bryan M. Grabias et al.   FASEB JOURNAL

Association of β-catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF-β1

(2012) Xinrui Tian et al.   JOURNAL OF CELL SCIENCE

Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis

(2012) Yingjian Li et al.   KIDNEY INTERNATIONAL

Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy

(2012) Xuanyi Du et al.   LABORATORY INVESTIGATION

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

(2012) Chiao-Yin Sun et al.   PLoS One

GSK3, Snail, and Adhesion Molecule Regulation by Cyclosporine A in Renal Tubular Cells

(2012) Sergio Berzal et al.   TOXICOLOGICAL SCIENCES

Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells

(2011) Xia Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

WT1 and Pax2 Re-Expression Is Required for Epithelial-Mesenchymal Transition in 5/6 Nephrectomized Rats and Cultured Kidney Tubular Epithelial Cells

(2011) Bin Huang et al.   CELLS TISSUES ORGANS

Erbin inhibits TGF-β1-induced EMT in renal tubular epithelial cells through an ERK-dependent pathway

(2011) Qiaodan Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Expression of transcription factor Snai1 and tubulointerstitial fibrosis in progressive nephropathy

(2011) Keiko Ohnuki et al.   JOURNAL OF NEPHROLOGY

Angiotensin II as a Morphogenic Cytokine Stimulating Renal Fibrogenesis

(2011) C. Ruster et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Role of the p38 MAPK Signaling Pathway in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Renal Tubular Epithelial Cells

(2011) Zhi-Mei Lv et al.   PLoS One

The Interaction of LFA-1 on Mononuclear Cells and ICAM-1 on Tubular Epithelial Cells Accelerates TGF-β1-Induced Renal Epithelial-Mesenchymal Transition

(2011) Yoshiyuki Morishita et al.   PLoS One

Differential regulation of Snail by hypoxia and hyperglycemia in human proximal tubule cells

(2010) Siska Sumual et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor

(2010) S. Saad et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

An integrative view on the role of TGF-β in the progressive tubular deletion associated with chronic kidney disease

(2010) Omar García-Sánchez et al.   KIDNEY INTERNATIONAL

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Role of Sema4C in TGF- 1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells

(2010) R. Zeng et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

(2009) Jose Miguel López-Novoa et al.   EMBO Molecular Medicine

RGC-32 Mediates Transforming Growth Factor-β-induced Epithelial-Mesenchymal Transition in Human Renal Proximal Tubular Cells

(2009) Wen-Yan Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parathyroid Hormone-Related Protein Promotes Epithelial-Mesenchymal Transition

(2009) J. A. Ardura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of Integrin-Linked Kinase Attenuates Renal Interstitial Fibrosis

(2009) Y. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease

(2009) Volker H. Haase   KIDNEY INTERNATIONAL

Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy

(2009) Xiaoyue Tan et al.   KIDNEY INTERNATIONAL

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY

Downregulation of E-cadherin is an essential event in activating β-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells

(2009) Q Wang et al.   ONCOGENE

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

(2008) X. Guo et al.   GENES & DEVELOPMENT

Snail Regulates Cell-Matrix Adhesion by Regulation of the Expression of Integrins and Basement Membrane Proteins

(2008) Misako Haraguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes

(2008) E L Whiteman et al.   ONCOGENE

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE

Arkadia regulates TGF-β signaling during renal tubular epithelial to mesenchymal cell transition

(2007) F.-Y. Liu et al.   KIDNEY INTERNATIONAL