Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells

PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium

(2013) Kota Fujiki et al.   ARCHIVES OF TOXICOLOGY

The Notch signaling pathway as a mediator of tumor survival

(2013) K. M. Capaccione et al.   CARCINOGENESIS

New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

(2013) Eric C. Hales et al.   CELLULAR SIGNALLING

Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia

(2013) Begoña Díaz et al.   JOURNAL OF CELL BIOLOGY

Notch activation promotes endothelial survival through a PI3K-Slug axis

(2013) Linda Chang et al.   MICROVASCULAR RESEARCH

Interference with Akt Signaling Protects Against Myocardial Infarction and Death by Limiting the Consequences of Oxidative Stress

(2013) B. A. Kerr et al.   Science Signaling

Effects of cadmium on the sub-cellular localization of β-catenin and β-catenin-regulated gene expression in NRK-52E cells

(2012) Joshua R. Edwards et al.   BIOMETALS

Notch1 activation promotes renal cell carcinoma growth via PI3K/Akt signaling

(2012) Le Xu et al.   CANCER SCIENCE

Notch signaling mediates TGF-β1-induced epithelial–mesenchymal transition through the induction of Snai1

(2012) Yosuke Matsuno et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Numb Protects Renal Proximal Tubular Cells from Puromycin Aminonucleoside-Induced Apoptosis through Inhibiting Notch Signaling Pathway

(2012) Xuebing Ding et al.   International Journal of Biological Sciences

Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways

(2012) Feng Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

(2012) Rui Du et al.   PLoS One

Notch Signaling

(2012) R. Kopan   Cold Spring Harbor Perspectives in Biology

Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of β-Catenin

(2011) Jianghui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo

(2011) Maki Tokumoto et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Cadmium induces phosphorylation and stabilization of c-Fos in HK-2 renal proximal tubular cells

(2011) Mamiko Iwatsuki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Notch signaling: Emerging molecular targets for cancer therapy

(2010) Ling Yin et al.   BIOCHEMICAL PHARMACOLOGY

Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells

(2010) Kristine C. Nyhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Notch signaling pathway: Molecular basis of cell context dependency

(2010) Ralf Schwanbeck et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

(2010) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor

(2010) S. Saad et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells

(2010) Prabir K Chakraborty et al.   Molecular Cancer

p53 Is Regulated by and Regulates Members of the γ-Secretase Complex

(2010) Frédéric Checler et al.   Neurodegenerative Diseases

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway

(2010) S Eliasz et al.   ONCOGENE

Switching Akt: from survival signaling to deadly response

(2009) Marek Los et al.   BIOESSAYS

p53-dependent control of transactivation of the Pen2 promoter by presenilins

(2009) J. Dunys et al.   JOURNAL OF CELL SCIENCE

Expression and clinical significance of Notch receptors in human renal cell carcinoma

(2009) Shiren Sun et al.   PATHOLOGY

Role of oxidative stress in cadmium toxicity and carcinogenesis

(2009) Jie Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Notch1 is an effector of Akt and hypoxia in melanoma development

(2008) Barbara Bedogni et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury

(2008) T. Kobayashi et al.   KIDNEY INTERNATIONAL

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilin 1/γ-Secretase Is Associated with Cadmium-Induced E-Cadherin Cleavage and COX-2 Gene Expression in T47D Breast Cancer Cells

(2008) Chang Seok Park et al.   TOXICOLOGICAL SCIENCES

Reciprocal regulation of Notch and PI3K/Akt signalling in T-ALL cells In Vitro

(2007) Elisabetta Calzavara et al.   JOURNAL OF CELLULAR BIOCHEMISTRY