Review
Biochemistry & Molecular Biology
Karla Rubio, Alejandro Molina-Herrera, Andrea Perez-Gonzalez, Hury Viridiana Hernandez-Galdamez, Carolina Pina-Vazquez, Tania Araujo-Ramos, Indrabahadur Singh
Summary: Fibrosis is a pathological condition characterized by excessive deposition of extracellular matrix proteins in tissues, leading to organ dysfunction and failure. Recent studies have highlighted the role of the histone acetyltransferase EP300 in mediating epigenetic changes associated with fibrosis. EP300-mediated histone acetylation alters chromatin structure and gene expression, promoting fibrosis development and progression. This review discusses the involvement of EP300 in multi-organ fibrosis and its potential as a therapeutic target, including the use of small molecule inhibitors and gene therapy approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marie-Christin Schulz, Linda Voss, Gerald Schwerdt, Michael Gekle
Summary: The pathogenesis of chronic kidney disease involves extracellular acidosis, inflammation, fibrosis, and epithelial-to-mesenchymal transition (EMT). This study examined the effects of acidosis on tubule epithelial cells and fibroblasts and explored the role of cell crosstalk in these effects. Acidosis led to increased inflammation, EMT, and fibrosis; however, in co-culture, these effects were reversed or inhibited. The intercellular crosstalk between epithelial cells and fibroblasts was found to have a protective function in acidosis-induced damage.
Article
Oncology
Masao Saitoh
Summary: The epithelial-mesenchymal transition (EMT) is a process where epithelial cells transform into mesenchymal cells, which is associated with invasion, metastasis, and resistance to therapy in cancer. Transcription factors, such as ZEB1/ZEB2, SNAIL, and TWIST, play important roles in driving the EMT process. This review focuses on understanding the molecular mechanisms that sustain high levels of these transcription factors in aggressive carcinomas and their upregulation by transforming growth factor-β during cancer progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Microbiology
Urbi Mukhopadhyay, Anwesha Banerjee, Mamta Chawla-Sarkar, Anupam Mukherjee
Summary: The study reveals miR-29b's crucial role in controlling RV-induced EMT and replication, suggesting its potential as an anti-viral agent against RV.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Surgery
Petra Hruba, Katelynn Madill-Thomsen, Martina Mackova, Jana Maluskova, Ludek Voska, Janka Slatinska, Philip F. Halloran, Ondrej Viklicky
Summary: Tubulitis with/without interstitial inflammation not meeting criteria for T-cell-mediated rejection is the most common histological finding in early transplant biopsies, and the course of transcriptional changes in sequential kidney graft biopsies has not been studied yet. Through molecular phenotyping using MMDx, it was found that the tubulitis classifier score at initial biopsy is the most significant predictor of rejection scores in follow-up biopsies, able to discriminate patients at risk for rejection.
TRANSPLANT INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Saurabh Pal, Neha Singh, Indra Dev, Vineeta Sharma, Anjaneya Ayanur, Pankaj Ramji Jagdale, Kausar Mahmood Ansari
Summary: In this study, the mechanism involved in pro-fibrotic changes in the kidney after low-dose chronic exposure to PAT was investigated using in vitro and in vivo approaches. The results demonstrated that PAT exposure caused the generation of reactive oxygen species (ROS), activation of MAPKs and cJun/Fos signaling pathways, and induction of TGF-β(1) expression. Additionally, it was found that PAT-induced TGF-β(1) further activated the TGF-β(1)/smad signaling pathways and modulated the expression of slug and snail, leading to the regulation of pro-fibrotic molecules. The in vivo results also confirmed the kidney injury/toxicity effects of PAT exposure in rats.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Hani Oweira, Ali Ramouz, Omid Ghamarnejad, Elias Khajeh, Sadeq Ali-Hasan-Al-Saegh, Rajan Nikbakhsh, Christoph Reissfelder, Nuh Rahbari, Arianeb Mehrabi, Mahmoud Sadeghi
Summary: Multiple factors influence graft rejection after kidney transplantation, including donor and recipient characteristics, as well as pre- and post-operative parameters. Identifying these risk factors helps reduce the risk of rejection and improve graft survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
David P. Cook, Barbara C. Vanderhyden
Summary: Epithelial-mesenchymal plasticity (EMP) is closely related to tumor progression, therapy resistance and immune cell evasion. By analyzing single-cell RNA sequencing data, we found diverse EMP expression patterns within tumors, which are regulated by various mechanisms initiated from the tumor microenvironment. Inferring regulatory features can provide effective therapeutic strategies to restrict EMP.
Article
Infectious Diseases
Alina Daciana Elec, Mihai Oltean, Patricia Goldis, Cristina Cismaru, Mihaela Lupse, Adriana Muntean, Florin Ioan Elec
Summary: This study reviewed 42 kidney transplant recipients with COVID-19, finding that antiretrovirals and RDV may increase the risk of renal impairment, but most patients can recover to baseline kidney function after discharge.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Ian T. Stancil, Jacob E. Michalski, Corinne E. Hennessy, Kristina L. Hatakka, Ivana Yang, Jonathan S. Kurche, Mercedes Rincon, David A. Schwartz
Summary: This study demonstrates that in lung injury and fibrotic lung disease, airway epithelial cells undergo aberrant fluidization, a process that is associated with activation of the IL-6 signaling pathway and dependence on the SFK-YAP axis. The fibrotic mesenchyme acts as a source of IL-6 family cytokines, driving airway fluidization. Inhibition of the IL-6-SFK-YAP cascade prevents fluidization from occurring.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Ping Xu, Hui Zhan, Rui Zhang, Xiu-jun Xu, Ying Zhang, Ying Le, Jian-gang Bi
Summary: In this study, the increased expressions of Egr1 and PAR1 were found in renal tissues of DKD rats. In vitro experiments showed that both Egr1 overexpression and high glucose condition could promote the expressions of PAR1, fibronectin, and collagen I. The binding capacity of Egr1 to PAR1 promoter was enhanced by HG stimulation.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Lukas Johannes Lehner, Robert Oellinger, Brigitta Globke, Marcel G. Naik, Klemens Budde, Johann Pratschke, Kai-Uwe Eckardt, Andreas Kahl, Kun Zhang, Fabian Halleck
Summary: Early pancreas graft loss within 3 months did not significantly impact patient or kidney graft survival over 10 years in this study.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Yi-Chieh Yang, Yung-Wei Lin, Wei-Jiunn Lee, Feng-Ru Lai, Kuo-Hao Ho, Chih-Ying Chu, Kuo-Tai Hua, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Yu-Ching Wen, Ming-Hsien Chien
Summary: The versatile RNA-binding protein KSRP plays a critical role in clear cell renal cell carcinoma (ccRCC) by promoting malignant progression through the transcriptional inhibition and post-transcriptional destabilization of NEDD4L transcripts. Targeting KSRP and its pathways could provide a new therapeutic intervention for ccRCC.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Immunology
Hannah Kaminski, Julie Belliere, Laure Burguet, Arnaud Del Bello, Benjamin Taton, Stephane Poirot-Mazeres, Isabelle Accoceberry, Laurence Delhaes, Jonathan Visentin, Marco Gregori, Xavier Iriart, Elena Charpentier, Lionel Couzi, Nassim Kamar, Pierre Merville
Summary: Late-onset Pneumocystis pneumonia (PCP) occurring approximately 3 years after transplantation is associated with risk factors such as low total lymphocyte count, use of mTOR inhibitors as maintenance immunosuppressive drugs, and administration of corticosteroid boluses for acute rejection. PCP is linked to high incidence of graft loss and patient death, highlighting the need for targeted prophylaxis based on simple criteria to prevent life-threatening complications.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Min Jun Seo, Dong Geon Lee, Se Yun Ko, Ga Yeong Song, Geon Yeong Lee, Sung Hwa Kim, Dae Ryong Kang, Jiye Kim, Jun Young Lee
Summary: Patients with end-stage kidney disease on dialysis are at a high risk of developing foot ulcerations and subsequent lower extremity amputation. Identifying risk factors associated with amputation can help predict and prevent its progression. Factors such as older age, male gender, lower income, non-metropolitan residence, diabetes mellitus, dialysis treatment, microvascular disease, peripheral vascular disease, endovascular procedure, and endovascular operation are associated with an increased risk of amputation. Close monitoring and consideration of kidney transplantation as a preventative measure are recommended for high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Kevin Louis, Alexandre Hertig, Jean-Luc Taupin, David Buob, Matthieu Jamme, Isabelle Brocheriou, Yosu Luque, Chantal Jouanneau, Nacera Ouali, Marie Audouin, Eric Rondeau, Yi-Chun Xu-Dubois
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Hematology
Christel Gerardin, Anissa Moktefi, Cecile Couchoud, Alyette Duquesne, Nacera Ouali, Philippe Gataut, Alexandre Karras, Dany Anglicheau, Carmen Lefaucheur, Lucile Figueres, Laetitia Albano, Arnaud Lionet, Marine Novion, Marie-Julia Ziliotis, Magali Louis, Arnaud Del Bello, Marie Matignon, Karine Dahan, Anoosha Habibi, Frederic Galacteros, Pablo Bartolucci, Philippe Grimbert, Vincent Audard
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Surgery
Yi-Chun Xu-Dubois, Pedram Ahmadpoor, Isabelle Brocheriou, Kevin Louis, Nadia Arzouk Snanoudj, Philippe Rouvier, Jean-Luc Taupin, Anthony Corchia, Pierre Galichon, Benoit Barrou, Sebastien Giraud, Thierry Hauet, Chantal Jouanneau, Anita Rodenas, Sandrine Placier, Aissata Niasse, Souhila Ouchelouche, Ben-Youssef Naimi, Elsa Akil, Alexandre Hertig, David Buob, Eric Rondeau
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Medicine, General & Internal
Alexandre Terre, Bertrand Knebelmann, David Buob, Marion Rabant, Olivier Lidove, Samuel Deshayes, Nacera Ouali, Gilles Grateau, Sophie Georgin-Lavialle
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2020)
Article
Dermatology
Alicia Moreno-Sabater, Nacera Ouali, Francois Chasset, Camille Frances, Patricia Senet, Caroline Faucon, Christophe Hennequin, Claude Bachmeyer
Summary: The study investigated the management of severe onychomycosis in kidney transplant recipients (KTR) and assessed the tolerance profile of systemic terbinafine in this population. Results indicated that oral terbinafine can be used to treat severe onychomycosis with acceptable tolerance in KTR receiving different antirejection treatments, such as tacrolimus. Further multicentric studies are needed to establish guidelines for onychomycosis treatment in KTR.
Article
Immunology
Thomas Barba, Emmanuel Bachy, Alizee Maarek, Gaelle Fossard, Laurent Genestier, Dany Anglicheau, Valerie Moal, Jacques Dantal, Philippe Rieu, Jonathan Chemouny, Manon Charrier, Antoine Durrbach, Francois Provot, Didier Ducloux, Pierre-Francois Westeel, Anne-Elisabeth Heng, Jean-Philippe Rerolle, Benoit Barrou, Philippe Grimbert, Valerie Chatelet, Christiane Mousson, Benedicte Janbon, Vincent Pernin, Luc Frimat, Nacera Ouali, Denis Glotz, Antoine Thierry, Christophe Mariat, Mathias Buchler, Philippe Gaulard, Veronique Leblond, Emmanuel Morelon, Valerie Dubois, Gilles Salles, Sophie Caillard, Olivier Thaunat
Summary: T/NK-cell PTLD occurs later after transplantation, has worse overall survival, with two subtypes: cutaneous and systemic, the latter having a poorer prognosis. Compared with T/NK-cell lymphomas in nontransplanted patients, systemic T/NK-cell PTLD has lower overall survival.
Article
Surgery
Francois Gaillard, Lola Jacquemont, Helene Lazareth, Laetitia Albano, Benoit Barrou, Nicolas Bouvier, Mathias Buchler, Dimitri Titeca-Beauport, Lionel Couzi, Michel Delahousse, Didier Ducloux, Isabelle Etienne, Luc Frimat, Cyril Garrouste, Denis Glotz, Philippe Grimbert, Marc Hazzan, Alexandre Hertig, Maryvonne Hourmant, Nassim Kamar, Yann Le Meur, Moglie Le Quintrec, Christophe Legendre, Valerie Moal, Bruno Moulin, Christiane Mousson, Claire Pouteil-Noble, Philippe Rieu, Nacera Ouali, Lionel Rostaing, Antoine Thierry, Fatouma Toure, Jonathan Chemouny, Pierre Delanaye, Marie Courbebaisse, Christophe Mariat
Summary: The study suggests that in-depth screening should be proposed to all candidates with a normal eGFR for age to increase the number of eligible kidney donors. Post-donation eGFR, absolute- and relative-eGFR variation were not significantly different between different pre-donation eGFR groups in younger donors, while older donors had higher post-donation eGFR in the group with eGFR >90 ml/min/1.73 m(2).
TRANSPLANT INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Antoine-Marie Molina Barragan, Emmanuel Pardo, Pierre Galichon, Nicolas Hantala, Anne-Charlotte Gianinazzi, Lucie Darrivere, Eileen S. Tsai, Marc Garnier, Francis Bonnet, Fabienne Fieux, Franck Verdonk
Summary: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to acute kidney injury (AKI) in ICU patients, with significant impact on mortality and other complications. Mechanical ventilation settings appear to play a critical role in kidney impairment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Charles Verney, David Legouis, Sandrine Placier, Tiffany Migeon, Philippe Bonnin, David Buob, Juliette Hadchouel, Pierre Galichon
Summary: A new technique for inducing renal ischemia in conscious mice was developed, showing rapid and reproducible results. Furthermore, the study revealed the renal protective effect of anesthesia in ischemia-reperfusion injury models, linked to the mitigation of the IRI transcriptomic program.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Transplantation
Emilie Savoye, Christophe Legendre, Yann Neuzillet, Marie-Noelle Peraldi, Philippe Grimbert, Nacera Ouali, Matthieu Durand, Lionel Badet, Francois Kerbaul, Myriam Pastural, Camille Legeai, Marie-Alice Macher, Renaud Snanoudj
Summary: This national multicentre retrospective cohort study aimed to evaluate the long-term outcomes of dual kidney transplantation (DKT) compared to single kidney transplantation (SKT). The results showed that DKT had better graft survival rates compared to SKT, while patient survival rates did not differ significantly. In the context of organ shortage, DKT is a good option for optimizing kidney utilization.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Letter
Urology & Nephrology
Arnaud Le Flecher, Alice Doreille, Pierre-Antoine Michel, Guillaume Hanouna, Eric Daugas, Hafedh Fessi, Pierre-Abel Claude, Emmanuel Esteve, Jean-Jacques Boffa, Andrey Strukov, Aurelia Retbi, Camille Petit-Hoang, Helene Francois, Nacera Ouali, Matthieu Jamme, Charles Verney, Eric Rondeau, Laurent Mesnard, Cedric Rafat, Yosu Luque
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Arthur Orieux, Antonin Bouchet, Alice Doreille, Liliana Paslaru, Marine Livrozet, Jean-Philippe Haymann, Nacera Ouali, Laurent Mesnard, Emmanuel Letavernier, Pierre Galichon
Summary: Research has found that glomerular filtration rate (GFR) decreases with age in living kidney donors, and low total kidney volume is a predictor of renal functional reserve (RFR). This suggests that the decrease in kidney function is an adaptive and reversible process, rather than age-related damage. Therefore, older individuals should not be excluded from kidney donation based on their low GFR.
WORLD JOURNAL OF UROLOGY
(2022)
Letter
Urology & Nephrology
Valentin Mayet, Cyril Mousseaux, Camille Petit-Hoang, Nacera Ouali, Cedric Rafat, Laurent Mesnard, Yosu Luque, Eric Rondeau, David Buob, Helene Francois
CLINICAL KIDNEY JOURNAL
(2020)
Correction
Endocrinology & Metabolism
David Legouis, Sven-Erick Ricksten, Anna Faivre, Thomas Verissimo, Karim Gariani, Charles Verney, Pierre Galichon, Lena Berchtold, Eric Feraille, Marylise Fernandez, Sandrine Placier, Kari Koppitch, Alexandre Hertig, Pierre-Yves Martin, Maarten Naesens, Jerome Pugin, Andrew P. McMahon, Pietro E. Cippa, Sophie de Seigneux
Article
Endocrinology & Metabolism
David Legouis, Sven-Erick Ricksten, Anna Faivre, Thomas Verissimo, Karim Gariani, Charles Verney, Pierre Galichon, Lena Berchtold, Eric Feraille, Marylise Fernandez, Sandrine Placier, Kari Koppitch, Alexandre Hertig, Pierre-Yves Martin, Maarten Naesens, Jerome Pugin, Andrew P. McMahon, Pietro E. Cipp, Sophie de Seigneux