Finding the Selectivity Switch - A Rational Approach towards Stereocomplementary Variants of the Ene Reductase YqjM

Pichia stipitis OYE 2.6 variants with improved catalytic efficiencies from site-saturation mutagenesis libraries

(2014) Athéna Patterson-Orazem et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New developments in ‘ene’-reductase catalysed biological hydrogenations

(2014) Helen S Toogood et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Residues Controlling Facial Selectivity in an Alkene Reductase and Semirational Alterations to Create Stereocomplementary Variants

(2014) Adam Z. Walton et al.   ACS Catalysis

Stereoselective Enzyme Cascades: An Efficient Synthesis of Chiral γ-Butyrolactones

(2014) Thomas Classen et al.   ACS Catalysis

Speeding up Directed Evolution: Combining the Advantages of Solid-Phase Combinatorial Gene Synthesis with Statistically Guided Reduction of Screening Effort

(2014) Sabrina Hoebenreich et al.   ACS Synthetic Biology

Total Synthesis of the Tubulin Inhibitor WF-1360F Based on Macrocycle Formation through Ring-Closing Alkyne Metathesis

(2013) Christian M. Neuhaus et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Importance of Additive and Non-Additive Mutational Effects in Protein Engineering

(2013) Manfred T. Reetz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future

(2013) Manfred T. Reetz   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

X-ray Crystallography Reveals How Subtle Changes Control the Orientation of Substrate Binding in an Alkene Reductase

(2013) Yuri A. Pompeu et al.   ACS Catalysis

Ene Reductase-Catalysed Synthesis of (R)-Profen Derivatives

(2012) Jörg Pietruszka et al.   ADVANCED SYNTHESIS & CATALYSIS

Structural and Catalytic Characterization of Pichia stipitis OYE 2.6, a Useful Biocatalyst for Asymmetric Alkene Reductions

(2012) Yuri A. Pompeu et al.   ADVANCED SYNTHESIS & CATALYSIS

Revisiting the Enantioselective Sequence Patterns in Enoate Reductases

(2012) Thomas Classen et al.   ChemCatChem

A Substrate-Driven Approach to Determine Reactivities of α,β-Unsaturated Carboxylic Esters Towards Asymmetric Bioreduction

(2012) Gábor Tasnádi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Stereo-Controlled Asymmetric Bioreduction of α,β-Dehydroamino Acid Derivatives

(2011) Clemens Stueckler et al.   ADVANCED SYNTHESIS & CATALYSIS

Chemoenzymatic One-Pot Synthesis of γ-Butyrolactones

(2011) Margarete Korpak et al.   ADVANCED SYNTHESIS & CATALYSIS

A Site-Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity

(2011) Helen S. Toogood et al.   CHEMBIOCHEM

Stereopreferences of Old Yellow Enzymes: Structure Correlations and Sequence Patterns in Enoate Reductases

(2011) Gustav Oberdorfer et al.   ChemCatChem

Biocatalytic Reductions of Baylis–Hillman Adducts

(2011) Adam Z. Walton et al.   ACS Catalysis

Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical outcome in reactions with α,β-unsaturated nitroolefins

(2011) Anna Fryszkowska et al.   Catalysis Science & Technology

Asymmetric Synthesis of (R)-3-Hydroxy-2-methylpropanoate (‘Roche Ester’) and Derivatives via Biocatalytic CC-Bond Reduction

(2010) Clemens Stueckler et al.   ADVANCED SYNTHESIS & CATALYSIS

Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions

(2010) Manfred T. Reetz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of O-Protected Acyloins Using Enoate Reductases: Stereochemical Control through Protecting Group Modification

(2010) Christoph K. Winkler et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

First Stereoselective Total Synthesis and Biological Evaluation of Amphidinin B and Its Analogues

(2010) Jhillu S. Yadav et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Directed Evolution of an Enantioselective Enoate-Reductase: Testing the Utility of Iterative Saturation Mutagenesis

(2009) Despina J. Bougioukou et al.   ADVANCED SYNTHESIS & CATALYSIS

Total Synthesis of Rapamycin

(2009) Steven V. Ley et al.   CHEMISTRY-A EUROPEAN JOURNAL

Site-Saturation Mutagenesis of Tryptophan 116 of Saccharomyces pastorianus Old Yellow Enzyme Uncovers Stereocomplementary Variants

(2009) Santosh Kumar Padhi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Bioreduction of CC Bonds using Enoate Reductases OPR1, OPR3 and YqjM: Enzyme-Based Stereocontrol

(2008) Mélanie Hall et al.   ADVANCED SYNTHESIS & CATALYSIS

Chemo-Enzymatic Synthesis of a Series of 2,4-Syn-Functionalized (S)-Glutamate Analogues: New Insight into the Structure−Activity Relation of Ionotropic Glutamate Receptor Subtypes 5, 6, and 7

(2008) Emanuelle Sagot et al.   JOURNAL OF MEDICINAL CHEMISTRY