Article
Plant Sciences
Aisling Ni Cheallaigh, David J. Mansell, Helen S. Toogood, Shirley Tait, Antonios Lygidakis, Nigel S. Scrutton, John M. Gardiner
JOURNAL OF NATURAL PRODUCTS
(2018)
Article
Chemistry, Medicinal
Binto Simon, Claire Walmsley, Victoria J. Jackson, Edward P. Garvey, Martin J. Slater, David J. Berrisford, John M. Gardiner
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Multidisciplinary
Issa S. Issa, Helen S. Toogood, Linus O. Johannissen, James Raftery, Nigel S. Scrutton, John M. Gardiner
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Multidisciplinary
Ahmed M. Mkadmh, Rami Y. Morjan, James Raftery, Adel M. Awadallah, John M. Gardiner
ARABIAN JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Organic
Robin A. Jeanneret, Charlotte E. Dalton, John M. Gardiner
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Mark A. Huffman, Anna Fryszkowska, Oscar Alvizo, Margie Borra-Garske, Kevin R. Campos, Keith A. Canada, Paul N. Devine, Da Duan, Jacob H. Forstater, Shane T. Grosser, Holst M. Halsey, Gregory J. Hughes, Junyong Jo, Leo A. Joyce, Joshua N. Kolev, Jack Liang, Kevin M. Maloney, Benjamin F. Mann, Nicholas M. Marshall, Mark McLaughlin, Jeffrey C. Moore, Grant S. Murphy, Christopher C. Nawrat, Jovana Nazor, Scott Novick, Niki R. Patel, Agustina Rodriguez-Granillo, Sandra A. Robaire, Edward C. Sherer, Matthew D. Truppo, Aaron M. Whittaker, Deeptak Verma, Li Xiao, Yingju Xu, Hao Yang
Review
Biochemistry & Molecular Biology
Anna Fryszkowska, Paul N. Devine
CURRENT OPINION IN CHEMICAL BIOLOGY
(2020)
Article
Chemistry, Organic
Niki R. Patel, Christopher C. Nawrat, Mark McLaughlin, Yingju Xu, Mark A. Huffman, Hao Yang, Hongming Li, Aaron M. Whittaker, Teresa Andreani, Francois Levesque, Anna Fryszkowska, Andrew Brunskill, David M. Tschaen, Kevin M. Maloney
Article
Chemistry, Physical
Shaoguang Zhang, Serge Ruccolo, Anna Fryszkowska, Artis Klapars, Nicholas Marshall, Neil A. Strotman
Summary: An electrochemical activation method for galactose oxidase (GOase) was developed to replace the expensive horseradish peroxidase activator in large-scale pharmaceutical processes. The study showed that the electron-transfer rates between GOase and various mediators depend on both the redox potential of the mediator and the pH. The electrochemical GOase activation method was successfully applied to the aerobic oxidation of benzyl alcohol derivatives and other compounds, including a key step in the biocatalytic cascade for the HIV therapeutic islatravir.
Article
Multidisciplinary Sciences
Anna Fryszkowska, Chihui An, Oscar Alvizo, Goutami Banerjee, Keith A. Canada, Yang Cao, Duane DeMong, Paul N. Devine, Da Duan, David M. Elgart, Iman Farasat, Donald R. Gauthier, Erin N. Guidry, Xiujuan Jia, Jongrock Kong, Nikki Kruse, Katrina W. Lexa, Alexey A. Makarov, Benjamin F. Mann, Erika M. Milczek, Vesna Mitchell, Jovana Nazor, Claudia Neri, Robert K. Orr, Peter Orth, Eric M. Phillips, James N. Riggins, Wes A. Schafer, Steven M. Silverman, Christopher A. Strulson, Nandhitha Subramanian, Rama Voladri, Hao Yang, Jie Yang, Xiang Yi, Xiyun Zhang, Wendy Zhong
Summary: This article introduces a bioconjugation strategy for selectively modifying native peptides using high site selectivity conveyed by engineered enzymes. By modifying certain amino groups and cleavable phenylacetamide groups in insulin, homogeneous bioconjugates with improved yield and purity were synthesized.
Article
Biochemistry & Molecular Biology
Saravanan Kandasamy, George F. S. Whitehead, Inigo J. Vitorica-Yrezabal, John M. Gardiner
Summary: 5-O-protected and 1,2-acetonide-protected D-glucurono-6,3-lactone furanosides were converted into novel furano-glucuronamides through treatment with ammonia. Different protection and deprotection routes led to primary gluconamide derivatives, while benzylations led to silyl migration, N-benzylation, or reclosure to lactone. The use of 5-O-PMB protection provided a method for obtaining fully protection-differentiated glucofuranamide. Crystal structures of fully protected glucurono-6,3-lactone lactone and glucuronamide derivatives were reported.
CARBOHYDRATE RESEARCH
(2023)
Article
Chemistry, Organic
Fahad Ayesh Alharthi, Garrett T. Potter, Gordon C. Jayson, George F. S. Whitehead, Inigo J. Vitorica-Yrezabal, John M. Gardiner
Summary: Reactions of a glucuronic acid (GlcA) beta-thioglyco-side with cyclohexadione result in the formation of two expected all-trans decalin-type O2,O3 and O3,O4 cyclohexane-1,2-diacetals (CDAs), along with an epimer of the main O2,O3 acetal. This trans-cis isomer is then converted to higher amounts of the two all-trans products. Isomerization studies demonstrate slow interconversion between the all-trans CDA acetals, with only one significant interconversion with the minor 2,3-diastereomer. Crystal structures of all three isomers are included. These findings are important for understanding the occurrence and interconversion of apparently disfavored isomers in other uses of CDA protections.
Article
Chemistry, Organic
Heather C. Johnson, Shaoguang Zhang, Anna Fryszkowska, Serge Ruccolo, Sandra A. Robaire, Artis Klapars, Niki R. Patel, Aaron M. Whittaker, Mark A. Huffman, Neil A. Strotman
Summary: Earth-abundant Mn(iii) complexes can be used as small molecule alternatives to expensive horseradish peroxidase (HRP) for activating galactose oxidase (GOase), with low loadings and good efficacy. While an induction period is observed with Mn(OAc)(3) activation, it can be eliminated by using other Mn(iii) sources, resulting in higher product conversions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Correction
Multidisciplinary Sciences
A. Fryszkowska, O. Alvizo, M. Borra-Garske, K. R. Campos, K. A. Canada, P. N. Devine, D. Duan, J. H. Forstater, S. T. Grosser, H. M. Halsey, G. J. Hughes, J. Jo, L. A. Joyce, J. N. Kolev, J. Liang, K. M. Maloney, B. F. Mann, N. M. Marshall, M. McLaughlin, J. C. Moore, G. S. Murphy, C. C. Nawrat, J. Nazor, S. Novick, N. R. Patel, A. Rodriguez-Granillo, S. A. Robaire, E. C. Sherer, M. D. Truppo, A. M. Whittaker, D. Verma, L. Xiao, Y. Xu, H. Yang
Article
Crystallography
Rami Y. Morjan, Said M. El-Kurdi, Jannat N. Azarah, Neda A. Eleiwa, Omar S. Abu-Teim, Adel M. Awadallah, James Raftery, John M. Gardiner
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2018)
Article
Chemistry, Physical
Zi-Ye Liu, Qian-Yu Wang, Ji-Ming Hu
Summary: In this study, a layered carbon dot composite catalyst (NiFe LDH@CDs) was prepared using a one-step coprecipitation method, without the need for heating or hydrothermal treatment. The CD-functionalized catalyst facilitated rapid charge transfer and accelerated the oxygen evolution reaction. Additionally, the heterojunction structure formed between NiFe LDH and CDs efficiently suppressed photoelectron-hole recombination.
CATALYSIS SCIENCE & TECHNOLOGY
(2024)
Article
Chemistry, Physical
Rohit Kumar, Ankit Kumar Srivastava, Palaniyappan Nagarasu, Vedichi Madhu, Ekambaram Balaraman
Summary: We designed and synthesized a NN-CoII bidentate complex and used it for the amination of alcohols under mild and solventless conditions. The complex exhibited good reactivity towards both primary and sterically hindered secondary alcohols, providing high yields of amines. The pyrazole moiety in the ligand played a crucial role in the reaction. Furthermore, we demonstrated the reusability of the complex as a homogeneous cobalt catalyst.
CATALYSIS SCIENCE & TECHNOLOGY
(2024)
Article
Chemistry, Physical
Shivanand Chettri, Liang-Ting Wu, Sagarmani Rasaily, Debesh Sharma, Bikram Gurung, Rajani Dewan, Sudarsan Tamang, Jyh-Chiang Jiang, Anand Pariyar
Summary: Replicating the enzymatic surface microenvironment in vitro is challenging, but constructing an analogous model could facilitate our understanding of surface effects and aid in developing an efficient bioinspired catalytic system. In this study, five unique Cu2O morphologies were generated, and the surface morphology variations were found to be a consequence of differences in the exposure of low-index facets. The reactivity of Cu2O was found to be influenced by the proportion of {110} planes, with r-Cu2O exhibiting the highest reactivity.
CATALYSIS SCIENCE & TECHNOLOGY
(2024)
Article
Chemistry, Physical
Yong Tang, Jianhao Qiu, Dingliang Dai, Guanglu Xia, Lu Zhang, Jianfeng Yao
Summary: Defect engineering has been shown to improve the photocatalytic performance. This study investigated the use of defect-rich UiO-66-NH2 wrapped by ZnIn2S4 as a catalyst for photocatalytic H2O2 production. The defects in UiO-66-NH2 enhanced O-2 adsorption and charge separation, leading to higher H2O2 yield. The insights from this work can advance the research in defect engineering of MOFs and photocatalytic H2O2 synthesis.
CATALYSIS SCIENCE & TECHNOLOGY
(2024)
Article
Chemistry, Physical
Ruiyang Qu, Shuxin Mao, Jana Weiss, Vita A. Kondratenko, Evgenii V. Kondratenko, Stephan Bartling, Haifeng Qi, Annette-Enrica Surkus, Kathrin Junge, Matthias Beller
Summary: The hydrogenation of amides, a challenging reaction usually performed at high temperatures, has been achieved under milder conditions using a new Pt-MoOx/TiO2 catalyst. This catalyst system enables the selective hydrogenation of various amides and imides.
CATALYSIS SCIENCE & TECHNOLOGY
(2024)
Article
Chemistry, Physical
Xiaoran Niu, Ao Wang, Lei Tong, Lei Wang, Yuan Kong, Chenliang Su, Hai-Wei Liang
Summary: This study introduces a novel intermetallic PdCu3 catalyst supported on defective nanodiamond-graphene (ND@G), which exhibits high selectivity (95%) and remarkable activity (turnover frequency: 2940 h(-1)), six times higher than that of the commercial Lindlar catalyst.
CATALYSIS SCIENCE & TECHNOLOGY
(2024)
Review
Chemistry, Physical
Zhiyuan Zheng, Yiming Yue, Hongying Zhuo, Qinggang Liu, Yanqiang Huang
Summary: This review presents the recent research advances on single-atom catalysis for deep reduction of CO2. Detailed introductions and summaries were classified into three categories based on proton-coupled multi-electron transfer approaches: strengthening metal-support interaction, rational design and regulation of coordination environment, and development of SACs with multi-atom active sites. The challenges and future research directions in the field of SACs for CO2 reduction are also proposed.
CATALYSIS SCIENCE & TECHNOLOGY
(2024)
Article
Chemistry, Physical
Shiv Kumar, Paramita Datta, Anup Bhunia, Swadhin K. Mandal
Summary: This article reports a transition-metal-free process for in situ denitrogenation of tosylhydrazones, resulting in the production of various sulfones. The authors used a phenalenyl-based odd alternant hydrocarbon as a photoredox catalyst, which acted as a potent oxidant to facilitate the denitrogenation reaction. The method showed wide functional-group tolerance and high yields, making it suitable for late-stage modification of natural products.
CATALYSIS SCIENCE & TECHNOLOGY
(2024)
Article
Chemistry, Physical
L. A. Luque-Alvarez, J. Gonzalez-Arias, F. Romero-Sarria, T. R. Reina, L. F. Bobadilla, J. A. Odriozola
Summary: Currently, the production of acetic acid through the carbonylation reaction of methanol has limitations, leading to the exploration of alternative methods using heterogeneous catalysts. This study investigates the methanol carbonylation reaction over a Cu-H-MOR catalyst and proposes a reaction mechanism based on the catalytic behavior and performance of the catalyst. The results provide insights into the reaction mechanism and the involvement of acid and redox centers.
CATALYSIS SCIENCE & TECHNOLOGY
(2024)