The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Fas/FasL, Bcl2 and Caspase-8 gene polymorphisms in Chinese patients with rheumatoid arthritis

(2016) Aiping Zhu et al.   RHEUMATOLOGY INTERNATIONAL

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

The BCL-2 protein family, BH3-mimetics and cancer therapy

(2015) A R D Delbridge et al.   CELL DEATH AND DIFFERENTIATION

The Origin of Tissue-Resident Macrophages: When an Erythro-myeloid Progenitor Is an Erythro-myeloid Progenitor

(2015) Elisa Gomez Perdiguero et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling

(2015) Yu-Jung Wu et al.   JOURNAL OF IMMUNOLOGY

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner

(2015) Carla M. Cuda et al.   ARTHRITIS RESEARCH & THERAPY

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

(2015) Qi-Quan Huang et al.   Nature Communications

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Ontogeny of Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   Frontiers in Immunology

Deletion of FADD in Macrophages and Granulocytes Results in RIP3- and MyD88-Dependent Systemic Inflammation

(2015) Suruchi N. Schock et al.   PLoS One

Regulation of the Immune System by the Resident Intestinal Bacteria

(2014) Nobuhiko Kamada et al.   GASTROENTEROLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Proapoptotic Activity of a Monomeric Smac Mimetic on Human Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis

(2014) D. Lattuada et al.   INFLAMMATION

Enhanced Dendritic Cell Survival Attenuates Lipopolysaccharide-Induced Immunosuppression and Increases Resistance to Lethal Endotoxic Shock

(2014) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 Acts as a Molecular Rheostat To Limit RIPK1- and MyD88-Mediated Dendritic Cell Activation

(2014) C. M. Cuda et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Endoplasmic Reticulum Stress Licenses Macrophages To Produce Mature IL-1  in Response to TLR4 Stimulation through a Caspase-8- and TRIF-Dependent Pathway

(2014) K. Shenderov et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Dietary modulation of the microbiome affects autoinflammatory disease

(2014) John R. Lukens et al.   NATURE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Modulation of immune development and function by intestinal microbiota

(2014) Agnieszka M. Kabat et al.   TRENDS IN IMMUNOLOGY

Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice

(2014) Alexander V. Misharin et al.   Cell Reports

Autophagy Regulates Phagocytosis by Modulating the Expression of Scavenger Receptors

(2013) Diana L. Bonilla et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense

(2013) Julia Farache et al.   IMMUNOLOGY AND CELL BIOLOGY

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis

(2013) Kate E. Lawlor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Autophagy: a dual role in the life and death of RASFs

(2013) Jenny Buckland   Nature Reviews Rheumatology

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

(2013) Luke C. Davies et al.   Nature Communications

Commensal Microbiota Are Required for Systemic Inflammation Triggered by Necrotic Dendritic Cells

(2013) Jennifer A. Young et al.   Cell Reports

Fas Signaling in Macrophages Promotes Chronicity in K/BxN Serum-Induced Arthritis

(2013) Qi-Quan Huang et al.   Arthritis & Rheumatology

Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Masaru Kato et al.   Arthritis & Rheumatology

Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFα in monocytes

(2012) Nathan D Chamberlain et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis

(2012) Neng-Yu Lin et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study

(2012) Mark C Genovese et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis

(2012) Ke Xu et al.   INFLAMMATION RESEARCH

Autophagy is central to joint destruction in arthritis

(2012) Sarah Onuora   Nature Reviews Rheumatology

Fas-associated death domain protein and adenosine partnership: fad in RA

(2012) V. Vilmont et al.   RHEUMATOLOGY

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in mice

(2011) Carla M. Cuda et al.   ARTHRITIS AND RHEUMATISM

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Collagen-induced arthritis and related animal models: How much of their pathogenesis is auto-immune, how much is auto-inflammatory?

(2011) Alfons Billiau et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation

(2011) Luke C. Davies et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein

(2011) Akhil Rajput et al.   IMMUNITY

Dendritic Cell and Macrophage Heterogeneity In Vivo

(2011) Daigo Hashimoto et al.   IMMUNITY

Caspase-8-mediated Cleavage Inhibits IRF-3 Protein by Facilitating Its Proteasome-mediated Degradation

(2011) Nathaniel Sears et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

(2011) Jamie M. Ireland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritis

(2011) Kate E. Lawlor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

Non-apoptotic role of BID in inflammation and innate immunity

(2011) Garabet Yeretssian et al.   NATURE

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Functional complementation between FADD and RIP1 in embryos and lymphocytes

(2011) Haibing Zhang et al.   NATURE

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Modulation of Macrophage Efferocytosis in Inflammation

(2011) Darlynn Korns et al.   Frontiers in Immunology

Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus

(2010) G. Orozco et al.   ANNALS OF THE RHEUMATIC DISEASES

Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis

(2010) John C. Scatizzi et al.   ARTHRITIS AND RHEUMATISM

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

(2010) Lisette Bevaart et al.   ARTHRITIS AND RHEUMATISM

FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis

(2010) Q.-Q. Huang et al.   BLOOD

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Regulation of steady-state neutrophil homeostasis by macrophages

(2010) C. Gordy et al.   BLOOD

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Role for toll-like receptors in autoimmune disease: The example of systemic lupus erythematosus

(2010) Christophe Richez et al.   JOINT BONE SPINE

Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis

(2010) Q. Huang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Apoptosis in the rheumatoid arthritis synovial membrane: modulation by disease-modifying anti-rheumatic drug treatment

(2010) M. D. Smith et al.   RHEUMATOLOGY

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress

(2010) Yong-Joo Shin et al.   ARTHRITIS RESEARCH & THERAPY

Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women

(2009) A M Delgado-Vega et al.   ANNALS OF THE RHEUMATIC DISEASES

Cell death in rheumatoid arthritis

(2009) Adelheid Korb et al.   APOPTOSIS

Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation

(2009) Lindsey A. Allan et al.   FEBS Journal

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

(2009) R J Palomino-Morales et al.   GENES AND IMMUNITY

Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

(2009) Natalia Wegner et al.   IMMUNOLOGICAL REVIEWS

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

(2009) Andrew Kovalenko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Bcl-2 Family Antagonist ABT-737 Significantly Inhibits Multiple Animal Models of Autoimmunity

(2009) P. D. Bardwell et al.   JOURNAL OF IMMUNOLOGY

BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention

(2009) J Hutcheson et al.   ONCOGENE

Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent

(2009) Noreen Pundt et al.   ARTHRITIS RESEARCH & THERAPY

Myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab

(2009) Christophe Richez et al.   ARTHRITIS RESEARCH & THERAPY

Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ

(2009) Hilde Kelchtermans et al.   ARTHRITIS RESEARCH & THERAPY

Rheumatoid Arthritis Synovium Contains Two Subsets of CD83−DC-LAMP− Dendritic Cells with Distinct Cytokine Profiles

(2008) M. Cristina Lebre et al.   AMERICAN JOURNAL OF PATHOLOGY

Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells

(2008) E. Gatza et al.   BLOOD

Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity

(2008) Jack Hutcheson et al.   IMMUNITY

Adenosine Receptors Control a New Pathway of Fas-associated Death Domain Protein Expression Regulation by Secretion

(2008) Léa Tourneur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY