Caspase-8-mediated Cleavage Inhibits IRF-3 Protein by Facilitating Its Proteasome-mediated Degradation

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein

(2011) Akhil Rajput et al.   IMMUNITY

The IRF-3/Bax-Mediated Apoptotic Pathway, Activated by Viral Cytoplasmic RNA and DNA, Inhibits Virus Replication

(2011) S. Chattopadhyay et al.   JOURNAL OF VIROLOGY

Phosphatidylinositol 3-Kinase Signaling Delays Sendai Virus-Induced Apoptosis by Preventing XIAP Degradation

(2011) C. L. White et al.   JOURNAL OF VIROLOGY

Viral apoptosis is induced by IRF-3-mediated activation of Bax

(2010) Saurabh Chattopadhyay et al.   EMBO JOURNAL

The Ubiquitin E3 Ligase RAUL Negatively Regulates Type I Interferon through Ubiquitination of the Transcription Factors IRF7 and IRF3

(2010) Yanxing Yu et al.   IMMUNITY

IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation

(2009) H-M Li et al.   CELL DEATH AND DIFFERENTIATION

The role of differential expression of human interferon-A genes in antiviral immunity

(2009) Pierre Génin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Identification of Caspase-mediated Decay of Interferon Regulatory Factor-3, Exploited by a Kaposi Sarcoma-associated Herpesvirus Immunoregulatory Protein

(2009) Cristina Aresté et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

(2009) Andrew Kovalenko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response

(2009) K. Yang et al.   JOURNAL OF IMMUNOLOGY

Viral Interferon Regulatory Factors

(2009) Hye-Ra Lee et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3

(2009) Wenwen Zeng et al.   MOLECULAR CELL

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases

(2008) M Rebsamen et al.   CELL DEATH AND DIFFERENTIATION

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

(2008) Min Zhang et al.   CELL RESEARCH

S-glutathionylation of IRF3 regulates IRF3–CBP interaction and activation of the IFNβ pathway

(2008) Efthimios Prinarakis et al.   EMBO JOURNAL

Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression

(2008) Toru Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRF-3 Activation by Sendai Virus Infection Is Required for Cellular Apoptosis and Avoidance of Persistence

(2008) K. Peters et al.   JOURNAL OF VIROLOGY