The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture

GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture.

(2021) Anne Bruggemans et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2

(2021) Kyle D. Pedro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 … and Viral Ways around It

(2021) Janina Deutschmann et al.   Viruses-Basel

Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus

(2021) Julie Janssens et al.   Frontiers in Microbiology

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

(2021) Steven G. Deeks et al.   NATURE MEDICINE

The H2A.Z-nucleosome code in mammals: emerging functions

(2021) Yolanda Colino-Sanguino et al.   TRENDS IN GENETICS

Genetic variability of Long Terminal Repeat region between HIV-2 groups impacts transcriptional activity

(2020) Quentin Le Hingrat et al.   JOURNAL OF VIROLOGY

Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure

(2020) Concepcion Casado et al.   Scientific Reports

Key Players in HIV-1 Transcriptional Regulation: Targets for a Functional Cure

(2020) Luisa Mori et al.   Viruses-Basel

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

(2020) Chenyang Jiang et al.   NATURE

Block and Lock HIV Cure Strategies to Control the Latent Reservoir

(2020) Chantelle L. Ahlenstiel et al.   Frontiers in Cellular and Infection Microbiology

Key Viral Adaptations Preceding the AIDS Pandemic

(2019) Daniel Sauter et al.   Cell Host & Microbe

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

(2019) Gerlinde Vansant et al.   Retrovirology

Behind the scenes of HIV-1 replication: Alternative splicing as the dependency factor on the quiet

(2018) Helene Sertznig et al.   VIROLOGY

HIV integration sites and implications for maintenance of the reservoir

(2018) Jori Symons et al.   Current Opinion in HIV and AIDS

Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells

(2018) Emilie Battivelli et al.   eLife

90-90-90 for HIV-2? Ending the HIV-2 epidemic by enhancing care and clinical management of patients infected with HIV-2

(2018) Geoffrey S Gottlieb et al.   Lancet HIV

HIV-2/SIV viral protein X counteracts HUSH repressor complex

(2018) Ghina Chougui et al.   Nature Microbiology

Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study

(2018) Joakim Esbjörnsson et al.   Lancet HIV

New Highly Sensitive Real-Time PCR Assay for HIV-2 Group A and Group B DNA Quantification

(2017) Mélanie Bertine et al.   JOURNAL OF CLINICAL MICROBIOLOGY

HIV Latency: Should We Shock or Lock?

(2017) Gilles Darcis et al.   TRENDS IN IMMUNOLOGY

Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression

(2017) Elena Heusinger et al.   Frontiers in Microbiology

INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes

(2017) Eric Sherman et al.   Molecular Therapy-Methods & Clinical Development

INSPIIRED: Quantification and Visualization Tools for Analyzing Integration Site Distributions

(2017) Charles C. Berry et al.   Molecular Therapy-Methods & Clinical Development

Hiv-2 molecular epidemiology

(2016) Benoit Visseaux et al.   INFECTION GENETICS AND EVOLUTION

Modulation of apoptosis and viral latency – an axis to be well understood for successful cure of human immunodeficiency virus

(2016) Uddhav Timilsina et al.   JOURNAL OF GENERAL VIROLOGY

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mortality and survival patterns of people living with HIV-2

(2016) Boris Tchounga et al.   Current Opinion in HIV and AIDS

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

(2016) Lenard S. Vranckx et al.   EBioMedicine

Understanding HIV Latency: The Road to an HIV Cure

(2015) Matthew S. Dahabieh et al.   Annual Review of Medicine

HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells

(2015) Lise Chauveau et al.   Retrovirology

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

(2015) I. A. Tchasovnikarova et al.   SCIENCE

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

(2015) Daniel Sauter et al.   Cell Reports

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells

(2015) Leonard Chavez et al.   PLoS Pathogens

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

(2014) Helena Nunes-Cabaço et al.   JOURNAL OF VIROLOGY

Mortality rates in people dually infected with HIV-1/2 and those infected with either HIV-1 or HIV-2

(2013) Puck D. Prince et al.   AIDS

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

(2013) Jocelyn O. Eidahl et al.   NUCLEIC ACIDS RESEARCH

BET proteins promote efficient murine leukemia virus integration at transcription start sites

(2013) A. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis

(2013) Samuel Nyamweya et al.   REVIEWS IN MEDICAL VIROLOGY

Dual-color HIV reporters trace a population of latently infected cells and enable their purification

(2013) Vincenzo Calvanese et al.   VIROLOGY

Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain

(2013) Rick van Nuland et al.   Epigenetics & Chromatin

The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

(2013) Jan De Rijck et al.   Cell Reports

Long-term nonprogressors and elite controllers in the ANRS CO5 HIV-2 cohort

(2011) Rodolphe Thiébaut et al.   AIDS

Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation

(2011) R. Soto-Rifo et al.   NUCLEIC ACIDS RESEARCH

Cell-Associated Viral Burden Provides Evidence of Ongoing Viral Replication in Aviremic HIV-2-Infected Patients

(2010) R. S. Soares et al.   JOURNAL OF VIROLOGY

Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins

(2010) Nadine Laguette et al.   MOLECULAR ASPECTS OF MEDICINE

Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village

(2010) Maarten van der Loeff et al.   Retrovirology

Comparison of viro-immunological marker changes between HIV-1 and HIV-2-infected patients in France

(2009) Julia Drylewicz et al.   AIDS

Differences in proviral DNA load between HIV-1- and HIV-2-infected patients

(2009) Marie Gueudin et al.   AIDS

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS