The H2A.Z-nucleosome code in mammals: emerging functions

Decoding the protein composition of whole nucleosomes with Nuc-MS

(2021) Luis F. Schachner et al.   NATURE METHODS

The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development

(2021) Mingjie Xu et al.   DEVELOPMENT

Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition

(2021) Nasim A Begum et al.   EMBO JOURNAL

A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation

(2021) Constantine Mylonas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells

(2021) Lauren Cole et al.   Nature Communications

Non‐redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression

(2021) Raquel Sales‐Gil et al.   EMBO REPORTS

Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma

(2021) Davide G. Berta et al.   NATURE

INO80 promotes H2A.Z occupancy to regulate cell fate transition in pluripotent stem cells

(2021) Hongyao Yu et al.   NUCLEIC ACIDS RESEARCH

The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons

(2021) Gilda Stefanelli et al.   Cell Reports

Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation

(2020) Assala Lamaa et al.   eLife

NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex

(2020) Noelle M. Olson et al.   BIOCHEMISTRY

Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells

(2020) Zengqi Wen et al.   NUCLEIC ACIDS RESEARCH

Vital and Distinct Roles of H2A.Z Isoforms in Hepatocellular Carcinoma

(2020) Shaomei Tang et al.   OncoTargets and Therapy

Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination

(2020) Jessica L. Kelliher et al.   Nature Communications

Deciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questions

(2020) Manjinder S. Cheema et al.   Cells

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance

(2020) Akihiko Numata et al.   BLOOD

Histone variants in skeletal myogenesis

(2020) Nandini Karthik et al.   Epigenetics

Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2

(2020) Min Zhou et al.   EMBO JOURNAL

Fetal alcohol spectrum disorder (FASD) affects the hippocampal levels of histone variant H2A.Z-2

(2019) Taylor L. Gretzinger et al.   Biochemistry and Cell Biology

Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

(2019) Bing Zhao et al.   Nature Communications

Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo

(2019) Yoon Hee Jung et al.   MOLECULAR CELL

Insights into active intragenic enhancers

(2019) Yong Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The histone variant H2A.Z in gene regulation

(2019) Benedetto Daniele Giaimo et al.   Epigenetics & Chromatin

Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy

(2019) Franziska Fröb et al.   Nature Communications

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

(2019) Zhijie Chen et al.   eLife

Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo

(2019) Naoki Horikoshi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single Amino Acid Change Underlies Distinct Roles of H2A.Z Subtypes in Human Syndrome

(2019) Rachel S. Greenberg et al.   CELL

DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription

(2019) M. Semer et al.   Nature Chemical Biology

Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain

(2019) Zhongqiu Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2A.Z facilitates licensing and activation of early replication origins

(2019) Haizhen Long et al.   NATURE

Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming

(2018) Patrick J. Murphy et al.   CELL

Histone Variant H2A.Z is Required for the Maintenance of Smooth Muscle Cell Identity as Revealed by Single-Cell Transcriptomics

(2018) Fang Yao et al.   CIRCULATION

Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response

(2018) Benedetto Daniele Giaimo et al.   NUCLEIC ACIDS RESEARCH

H2A.Z.1 crosstalk with H3K56-acetylation controls gliogenesis through the transcription of folate receptor

(2018) Libo Su et al.   NUCLEIC ACIDS RESEARCH

Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus

(2018) Gilda Stefanelli et al.   Cell Reports

Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity

(2018) Chih-Chao Hsu et al.   Cell Discovery

Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells

(2018) Yan Wang et al.   BMC BIOLOGY

Automated single-molecule imaging in living cells

(2018) Masato Yasui et al.   Nature Communications

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes

(2018) Tianyi Zhang et al.   Nature Communications

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

(2018) Stephanie Link et al.   Nature Communications

The histone variant H2A.Z promotes splicing of weak introns

(2017) Kelly E. Nissen et al.   GENES & DEVELOPMENT

The histone variant H2A.Z promotes efficient cotranscriptional splicing in S. cerevisiae

(2017) Lauren T. Neves et al.   GENES & DEVELOPMENT

Variants of core histones and their roles in cell fate decisions, development and cancer

(2017) Marcus Buschbeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast

(2017) Shintaro Yamada et al.   NUCLEIC ACIDS RESEARCH

Global inhibition of transcription causes an increase in histone H2A.Z incorporation within gene bodies

(2017) Anahita Lashgari et al.   NUCLEIC ACIDS RESEARCH

CHD1 regulates cell fate determination by activation of differentiation-induced genes

(2017) Simon J. Baumgart et al.   NUCLEIC ACIDS RESEARCH

Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder

(2017) Tianjin Shen et al.   NUCLEIC ACIDS RESEARCH

Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells

(2017) Juri Kazakevych et al.   NUCLEIC ACIDS RESEARCH

H2A O-GlcNAcylation at serine 40 functions genomic protection in association with acetylated H2AZ or γH2AX

(2017) Koji Hayakawa et al.   Epigenetics & Chromatin

Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2

(2017) Buqing Ye et al.   Nature Communications

Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer

(2017) Fátima Valdés-Mora et al.   Nature Communications

The Histone Variant H2A.Z Is a Master Regulator of the Epithelial-Mesenchymal Transition

(2017) Renae Domaschenz et al.   Cell Reports

SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites

(2017) Atsuhiko Fukuto et al.   Nucleus

SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites

(2017) Atsuhiko Fukuto et al.   Nucleus

SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation

(2016) C.-H. Tsai et al.   CANCER RESEARCH

EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation

(2016) Suman K. Pradhan et al.   MOLECULAR CELL

Enhancer–promoter interactions are encoded by complex genomic signatures on looping chromatin

(2016) Sean Whalen et al.   NATURE GENETICS

HiChIP: efficient and sensitive analysis of protein-directed genome architecture

(2016) Maxwell R Mumbach et al.   NATURE METHODS

Chromatin remodeling inactivates activity genes and regulates neural coding

(2016) Yue Yang et al.   SCIENCE

H2A.Z controls the stability and mobility of nucleosomes to regulate expression of the LH genes

(2016) Sergei Rudnizky et al.   Nature Communications

Oncogenic potential of histone-variant H2A.Z.1 and its regulatory role in cell cycle and epithelial-mesenchymal transition in liver cancer

(2016) Hee Doo Yang et al.   Oncotarget

Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A

(2016) Naoki Horikoshi et al.   Open Biology

Removal of H2A.Z by INO80 promotes homologous recombination

(2015) H. E. Alatwi et al.   EMBO REPORTS

The chromatin environment shapes DNA replication origin organization and defines origin classes

(2015) Christelle Cayrou et al.   GENOME RESEARCH

Expression of Non-acetylatable H2A.Z in Myoblast Cells Blocks Myoblast Differentiation through Disruption of MyoD Expression

(2015) Cindy Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of common variants in H2AFZ gene with schizophrenia and cognitive function in patients with schizophrenia

(2015) Ming Chang et al.   JOURNAL OF HUMAN GENETICS

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma

(2015) Chiara Vardabasso et al.   MOLECULAR CELL

Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair

(2015) Ozge Gursoy-Yuzugullu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z

(2014) Zhuo Mao et al.   CELL RESEARCH

Nucleosomes Are Context-Specific, H2A.Z-Modulated Barriers to RNA Polymerase

(2014) Christopher M. Weber et al.   MOLECULAR CELL

ANP32E is a histone chaperone that removes H2A.Z from chromatin

(2014) Arnaud Obri et al.   NATURE

Histone H2A.Z subunit exchange controls consolidation of recent and remote memory

(2014) Iva B. Zovkic et al.   NATURE

Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression

(2014) Thomas Kusch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation

(2014) C.-L. Hsieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2

(2013) Naoki Horikoshi et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Histone variants: emerging players in cancer biology

(2013) Chiara Vardabasso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal

(2013) Olivier Binda et al.   Epigenetics

H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin

(2013) P. Chen et al.   GENES & DEVELOPMENT

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

(2013) Wenbo Li et al.   NATURE

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene dysregulation by histone variant H2A.Z in bladder cancer

(2013) Kyunghwan Kim et al.   Epigenetics & Chromatin

TIP48/Reptin and H2A.Z Requirement for Initiating Chromatin Remodeling in Estrogen-Activated Transcription

(2013) Mathieu Dalvai et al.   PLoS Genetics

Foxa2 and H2A.Z Mediate Nucleosome Depletion during Embryonic Stem Cell Differentiation

(2012) Zhaoyu Li et al.   CELL

H2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-Renewal and Differentiation

(2012) Gangqing Hu et al.   Cell Stem Cell

Analysis of active chromatin modifications in early mammalian embryos reveals uncoupling of H2A.Z acetylation and H3K36 trimethylation from embryonic genome activation

(2012) Ana Bošković et al.   Epigenetics

A Conserved Function for the H2A.Z C Terminus

(2012) Daniel Wratting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair

(2012) Ye Xu et al.   MOLECULAR CELL

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics

(2012) Maxim Nekrasov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization

(2012) Clemens Bönisch et al.   NUCLEIC ACIDS RESEARCH

H2A.Z-dependent crosstalk between enhancer and promoter regulates Cyclin D1 expression

(2012) M Dalvai et al.   ONCOGENE

A Combination of H2A.Z and H4 Acetylation Recruits Brd2 to Chromatin during Transcriptional Activation

(2012) Ryan Draker et al.   PLoS Genetics

H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

(2012) Manching Ku et al.   GENOME BIOLOGY

Histone H2A.Z prepares the prostate specific antigen (PSA) gene for androgen receptor-mediated transcription and is upregulated in a model of prostate cancer progression

(2011) Deanna Dryhurst et al.   CANCER LETTERS

Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer

(2011) F. Valdes-Mora et al.   GENOME RESEARCH

USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation

(2011) Ryan Draker et al.   NUCLEIC ACIDS RESEARCH

Histone Variant H2A.Z Inhibits Transcription in Reconstituted Nucleosomes

(2010) Amit Thakar et al.   BIOCHEMISTRY

Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice

(2010) B. Nashun et al.   DEVELOPMENT

Histone Variants in Metazoan Development

(2010) Laura A. Banaszynski et al.   DEVELOPMENTAL CELL

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

(2010) Ye Xu et al.   JOURNAL OF CELL BIOLOGY

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

H2A.Z nucleosomes enriched over active genes are homotypic

(2010) Christopher M Weber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification and characterization of the two isoforms of the vertebrate H2A.Z histone variant

(2010) Ryo Matsuda et al.   NUCLEIC ACIDS RESEARCH

Roles for H2A.Z and Its Acetylation in GAL1 Transcription and Gene Induction, but Not GAL1-Transcriptional Memory

(2010) Jeffrey E. Halley et al.   PLOS BIOLOGY

Acetylation of Vertebrate H2A.Z and Its Effect on the Structure of the Nucleosome

(2009) Toyotaka Ishibashi et al.   BIOCHEMISTRY

Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates

(2009) Deanna Dryhurst et al.   BMC BIOLOGY

The evolutionary differentiation of two histone H2A.Z variants in chordates (H2A.Z-1 and H2A.Z-2) is mediated by a stepwise mutation process that affects three amino acid residues

(2009) José M Eirín-López et al.   BMC EVOLUTIONARY BIOLOGY

H3.3/H2A.Z double variant–containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions

(2009) Chunyuan Jin et al.   NATURE GENETICS

The Euchromatic and Heterochromatic Landscapes Are Shaped by Antagonizing Effects of Transcription on H2A.Z Deposition

(2009) Sara Hardy et al.   PLoS Genetics

H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment

(2008) Menno P. Creyghton et al.   CELL

Loss of the Histone Variant H2A.Z Restores Capping to Checkpoint-Defective Telomeres in Drosophila

(2008) Y. S. Rong   GENETICS