Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen

Treponema pallidum Lipoprotein TP0435 Expressed in Borrelia burgdorferi Produces Multiple Surface/Periplasmic Isoforms and mediates Adherence

(2016) Kamfai Chan et al.   Scientific Reports

Diversity of membrane transport proteins for vitamins in bacteria and archaea

(2015) Michael Jaehme et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Loss of NADH Oxidase Activity in Streptococcus mutans Leads to Rex-Mediated Overcompensation in NAD+Regeneration by Lactate Dehydrogenase

(2015) J. L. Baker et al.   JOURNAL OF BACTERIOLOGY

Evidence that TP_0144 of Treponema pallidum Is a Thiamine-Binding Protein

(2015) Jiang Bian et al.   JOURNAL OF BACTERIOLOGY

A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326

(2015) Amit Luthra et al.   JOURNAL OF BACTERIOLOGY

Bipartite Topology ofTreponema pallidumRepeat Proteins C/D and I

(2015) Arvind Anand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flagellar motility of the pathogenic spirochetes

(2015) Charles W. Wolgemuth   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Treponema pallidum subsp. pallidum TP0136 Protein Is Heterogeneous among Isolates and Binds Cellular and Plasma Fibronectin via its NH2-Terminal End

(2015) Wujian Ke et al.   PLoS Neglected Tropical Diseases

Global epidemiology of yaws: a systematic review

(2015) Oriol Mitjà et al.   Lancet Global Health

Identification of Functional Candidates amongst Hypothetical Proteins of Treponema pallidum ssp. pallidum

(2015) Ahmad Abu Turab Naqvi et al.   PLoS One

New Insights into Bacterial Chemoreceptor Array Structure and Assembly from Electron Cryotomography

(2014) Ariane Briegel et al.   BIOCHEMISTRY

The Endemic Treponematoses

(2014) L. Giacani et al.   CLINICAL MICROBIOLOGY REVIEWS

Stress-Induced Remodeling of the Bacterial Proteome

(2014) Monica S. Guo et al.   CURRENT BIOLOGY

Antigenic Variation of TprK Facilitates Development of Secondary Syphilis

(2014) Tara B. Reid et al.   INFECTION AND IMMUNITY

The Bacterial Phosphoenolpyruvate:Carbohydrate Phosphotransferase System: Regulation by Protein Phosphorylation and Phosphorylation-Dependent Protein-Protein Interactions

(2014) Josef Deutscher et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Insights into the potential function and membrane organization of the TP0435 (Tp17) lipoprotein fromTreponema pallidumderived from structural and biophysical analyses

(2014) Chad A. Brautigam et al.   PROTEIN SCIENCE

Whole Genome Sequence of the Treponema pallidum subsp. endemicum Strain Bosnia A: The Genome Is Related to Yaws Treponemes but Contains Few Loci Similar to Syphilis Treponemes

(2014) Barbora Štaudová et al.   PLoS Neglected Tropical Diseases

Assembly of β-barrel proteins into bacterial outer membranes

(2013) Joel Selkrig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The sound of silence: missing the opportunity to save lives at birth

(2013) Jeffrey D Klausner   BULLETIN OF THE WORLD HEALTH ORGANIZATION

The Major Outer Sheath Protein (Msp) of Treponema denticola Has a Bipartite Domain Architecture and Exists as Periplasmic and Outer Membrane-Spanning Conformers

(2013) A. Anand et al.   JOURNAL OF BACTERIOLOGY

The TP0796 Lipoprotein ofTreponema pallidumIs a Bimetal-dependent FAD Pyrophosphatase with a Potential Role in Flavin Homeostasis

(2013) Ranjit K. Deka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The multifunctional role of the pallilysin-associatedTreponema pallidumprotein, Tp0750, in promoting fibrinolysis and extracellular matrix component degradation

(2013) Simon Houston et al.   MOLECULAR MICROBIOLOGY

Structural insight into the biogenesis of β-barrel membrane proteins

(2013) Nicholas Noinaj et al.   NATURE

MyD88 Deficiency Markedly Worsens Tissue Inflammation and Bacterial Clearance in Mice Infected with Treponema pallidum, the Agent of Syphilis

(2013) Adam C. Silver et al.   PLoS One

Resequencing of Treponema pallidum ssp. pallidum Strains Nichols and SS14: Correction of Sequencing Errors Resulted in Increased Separation of Syphilis Treponeme Subclusters

(2013) Helena Pětrošová et al.   PLoS One

Current status of syphilis vaccine development: Need, challenges, prospects

(2013) Caroline E. Cameron et al.   VACCINE

Is there a difference between hare syphilis and rabbit syphilis? Cross infection experiments between rabbits and hares

(2013) Johannes T. Lumeij et al.   VETERINARY MICROBIOLOGY

Fine Analysis of Genetic Diversity of the tpr Gene Family among Treponemal Species, Subspecies and Strains

(2013) Arturo Centurion-Lara et al.   PLoS Neglected Tropical Diseases

Ferroportin-mediated iron transport: Expression and regulation

(2012) Diane M. Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of the Treponema pallidum subsp. pallidum TP0092 (RpoE) Regulon and Its Implications for Pathogen Persistence in the Host and Syphilis Pathogenesis

(2012) L. Giacani et al.   JOURNAL OF BACTERIOLOGY

Biophysical and Bioinformatic Analyses Implicate the Treponema pallidum Tp34 Lipoprotein (Tp0971) in Transition Metal Homeostasis

(2012) C. A. Brautigam et al.   JOURNAL OF BACTERIOLOGY

TprC/D (Tp0117/131), a Trimeric, Pore-Forming Rare Outer Membrane Protein of Treponema pallidum, Has a Bipartite Domain Structure

(2012) A. Anand et al.   JOURNAL OF BACTERIOLOGY

Comparative Investigation of the Genomic Regions Involved in Antigenic Variation of the TprK Antigen among Treponemal Species, Subspecies, and Strains

(2012) L. Giacani et al.   JOURNAL OF BACTERIOLOGY

Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter

(2012) Ranjit K. Deka et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Thermodynamic Characterization of the Interaction between Two Periplasmic Treponema pallidum Lipoproteins that are Components of a TPR-Protein-Associated TRAP Transporter (TPAT)

(2012) Chad A. Brautigam et al.   JOURNAL OF MOLECULAR BIOLOGY

The Role of Bacterial Enhancer Binding Proteins as Specialized Activators of  54-Dependent Transcription

(2012) M. Bush et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structural basis for iron piracy by pathogenic Neisseria

(2012) Nicholas Noinaj et al.   NATURE

Whole Genome Sequence of Treponema pallidum ssp. pallidum, Strain Mexico A, Suggests Recombination between Yaws and Syphilis Strains

(2012) Helena Pětrošová et al.   PLoS Neglected Tropical Diseases

Immune Evasion and Recognition of the Syphilis Spirochete in Blood and Skin of Secondary Syphilis Patients: Two Immunologically Distinct Compartments

(2012) Adriana R. Cruz et al.   PLoS Neglected Tropical Diseases

Whole Genome Sequences of Three Treponema pallidum ssp. pertenue Strains: Yaws and Syphilis Treponemes Differ in Less than 0.2% of the Genome Sequence

(2012) Darina Čejková et al.   PLoS Neglected Tropical Diseases

Activation and Proteolytic Activity of the Treponema pallidum Metalloprotease, Pallilysin

(2012) Simon Houston et al.   PLoS Pathogens

Genetic diversity in Treponema pallidum: Implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws

(2011) David Šmajs et al.   INFECTION GENETICS AND EVOLUTION

Characterization of a Dipartite Iron Uptake System from UropathogenicEscherichia coliStrain F11

(2011) Doreen Koch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transition from Closed to Open Conformation ofTreponema pallidumOuter Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices

(2011) Amit Luthra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syphilis: using modern approaches to understand an old disease

(2011) Emily L. Ho et al.   JOURNAL OF CLINICAL INVESTIGATION

TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein

(2011) Daniel C. Desrosiers et al.   MOLECULAR MICROBIOLOGY

Complete Genome Sequence of Treponema paraluiscuniculi, Strain Cuniculi A: The Loss of Infectivity to Humans Is Associated with Genome Decay

(2011) David Šmajs et al.   PLoS One

Host Defense Mechanisms in Secondary Syphilitic Lesions

(2010) Georg Stary et al.   AMERICAN JOURNAL OF PATHOLOGY

The mechanism of signal transduction by two-component systems

(2010) Patricia Casino et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Surface Immunolabeling and Consensus Computational Framework To Identify Candidate Rare Outer Membrane Proteins of Treponema pallidum

(2010) D. L. Cox et al.   INFECTION AND IMMUNITY

Antigenic Variation in Treponema pallidum: TprK Sequence Diversity Accumulates in Response to Immune Pressure during Experimental Syphilis

(2010) L. Giacani et al.   JOURNAL OF IMMUNOLOGY

Cellular Architecture of Treponema pallidum: Novel Flagellum, Periplasmic Cone, and Cell Envelope as Revealed by Cryo Electron Tomography

(2010) Jun Liu et al.   JOURNAL OF MOLECULAR BIOLOGY

Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum

(2010) D. Parsonage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory roles of the bacterial nitrogen-related phosphotransferase system

(2010) Katharina Pflüger-Grau et al.   TRENDS IN MICROBIOLOGY

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Secondary Syphilis in Cali, Colombia: New Concepts in Disease Pathogenesis

(2010) Adriana R. Cruz et al.   PLoS Neglected Tropical Diseases

Cryo-Electron Tomography Elucidates the Molecular Architecture of Treponema pallidum, the Syphilis Spirochete

(2009) J. Izard et al.   JOURNAL OF BACTERIOLOGY

Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens

(2009) Kirk W. Deitsch et al.   NATURE REVIEWS MICROBIOLOGY

Scientific Monogamy: Thirty Years Dancing with the Same Bug

(2009) Sheila A. Lukehart   SEXUALLY TRANSMITTED DISEASES

Sense and sensibility: flagellum-mediated gene regulation

(2009) Jennifer K. Anderson et al.   TRENDS IN MICROBIOLOGY

Cellular Defenses against Superoxide and Hydrogen Peroxide

(2008) James A. Imlay   Annual Review of Biochemistry

A Novel Treponema pallidum Antigen, TP0136, Is an Outer Membrane Protein That Binds Human Fibronectin

(2008) M. B. Brinkman et al.   INFECTION AND IMMUNITY

Carbon catabolite repression in bacteria: many ways to make the most out of nutrients

(2008) Boris Görke et al.   NATURE REVIEWS MICROBIOLOGY