Data-driven structural analysis of small cell lung cancer transcription factor network suggests potential subtype regulators and transition pathways

Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer

(2022) Sarah M. Groves et al.   Cell Systems

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

(2021) Carl M. Gay et al.   CANCER CELL

Network Topological Analysis for the Identification of Novel Hubs in Plant Nutrition

(2021) Dario Di Silvestre et al.   Frontiers in Plant Science

Cancer cells retrace a stepwise differentiation program during malignant progression

(2021) Sadegh Saghafinia et al.   Cancer Discovery

ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer

(2021) Rachelle R. Olsen et al.   GENES & DEVELOPMENT

Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium

(2021) Jasmine Chen et al.   ONCOGENE

MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate

(2020) Abbie S. Ireland et al.   CANCER CELL

Cellular Plasticity in Breast Cancer Progression and Therapy

(2020) Deguang Kong et al.   Frontiers in Molecular Biosciences

Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization

(2020) Marina K. Baine et al.   Journal of Thoracic Oncology

Network hubs affect evolvability

(2019) Jana Helsen et al.   PLOS BIOLOGY

Cellular Plasticity in Cancer

(2019) Salina Yuan et al.   Cancer Discovery

MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion

(2019) Milind D. Chalishazar et al.   CLINICAL CANCER RESEARCH

Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities

(2019) Florian Rambow et al.   GENES & DEVELOPMENT

Cell differentiation: what have we learned in 50 years?

(2019) Stuart A. Newman   JOURNAL OF THEORETICAL BIOLOGY

Identification of Hub Genes and Key Pathways Associated With Bipolar Disorder Based on Weighted Gene Co-expression Network Analysis

(2019) Yang Liu et al.   Frontiers in Physiology

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

(2019) David J. Wooten et al.   PLoS Computational Biology

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

(2018) Yu-Han Huang et al.   GENES & DEVELOPMENT

Predicting perturbation patterns from the topology of biological networks

(2018) Marc Santolini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inferring gene expression networks with hubs using a degree weighted Lasso approach

(2018) Nurgazy Sulaimanov et al.   BIOINFORMATICS

FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer

(2018) Lingyu Li et al.   CLINICAL CANCER RESEARCH

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

(2017) Jing Shan Lim et al.   NATURE

Friend leukemia virus integration 1 promotes tumorigenesis of small cell lung cancer cells by activating the miR-17-92 pathway

(2017) Lingyu Li et al.   Oncotarget

Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity

(2016) Akshata R. Udyavar et al.   CANCER RESEARCH

YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer

(2016) Masafumi Horie et al.   CANCER SCIENCE

Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness

(2016) Alexander Nguyen et al.   Nature Communications

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

(2016) Mark D. Borromeo et al.   Cell Reports

Origins, genetic landscape, and emerging therapies of small cell lung cancer

(2015) Ekaterina A. Semenova et al.   GENES & DEVELOPMENT

Treatment of Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American College of Chest Physicians Guideline

(2015) Charles M. Rudin et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Small cell lung cancer: Where do we go from here?

(2014) Lauren Averett Byers et al.   CANCER

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

(2014) A. Augustyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems biology approaches to develop innovative strategies for lung cancer therapy

(2014) K Viktorsson et al.   Cell Death & Disease

Network analysis in the identification of special mechanisms between small cell lung cancer and non-small cell lung cancer

(2014) Weisan Zhang et al.   Thoracic Cancer

Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells

(2013) Sui Huang   CANCER AND METASTASIS REVIEWS

An edge-swap heuristic for generating spanning trees with minimum number of branch vertices

(2013) Ricardo M. A. Silva et al.   Optimization Letters

Structural and dynamical analysis of biological networks

(2012) Cecilia Klein et al.   Briefings in Functional Genomics

Topological analysis and interactive visualization of biological networks and protein structures

(2012) Nadezhda T Doncheva et al.   Nature Protocols

Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis

(2012) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors

(2012) Annika Jögi et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

(2011) Joaquim Calbo et al.   CANCER CELL

Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung

(2011) Kate D. Sutherland et al.   CANCER CELL

Characterization of the cell of origin for small cell lung cancer

(2011) Kwon-Sik Park et al.   CELL CYCLE

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

Hubs and bottlenecks in plant molecular signalling networks

(2010) Karl-Josef Dietz et al.   NEW PHYTOLOGIST

Hypoxic Tumor Microenvironment and Cancer Cell Differentiation

(2009) Yuri Kim et al.   CURRENT MOLECULAR MEDICINE

Systems biology of stem cell fate and cellular reprogramming

(2009) Ben D. MacArthur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY