Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

HIF-1  and HIF-2  Are Differentially Regulated In vivo in Neuroblastoma: High HIF-1  Correlates Negatively to Advanced Clinical Stage and Tumor Vascularization

(2009) R. Noguera et al.   CLINICAL CANCER RESEARCH

Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease

(2009) Volker H. Haase   KIDNEY INTERNATIONAL

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

HIF-2  maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells

(2009) A. Pietras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells

(2008) Jeongwu Lee et al.   CANCER CELL

Hypoxia-Inducible Factor-2  Correlates to Distant Recurrence and Poor Outcome in Invasive Breast Cancer

(2008) K. Helczynska et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma

(2008) E. Fredlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA