The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing

The somatotropic axis and longevity in mice

(2015) H. M. Brown-Borg   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: From discovery to patients

(2015) ECM de Lange et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation

(2015) Licio A. Velloso et al.   ENDOCRINE REVIEWS

TLR4 Expression in Bone Marrow-Derived Cells Is Both Necessary and Sufficient to Produce the Insulin Resistance Phenotype in Diet-Induced Obesity

(2015) Daniela S. Razolli et al.   ENDOCRINOLOGY

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Hypothalamic innate immune reaction in obesity

(2015) Stefanie Kälin et al.   Nature Reviews Endocrinology

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

(2015) John H. Lee et al.   NEURON

Neuropeptide Y stimulates autophagy in hypothalamic neurons

(2015) Célia A. Aveleira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Venous Thromboprophylaxis in Gastrointestinal Bleeding

(2015) Neel Malhotra et al.   Canadian Journal of Gastroenterology and Hepatology

Saturated Fatty Acids Modulate Autophagy’s Proteins in the Hypothalamus

(2015) Mariana Portovedo et al.   PLoS One

Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity

(2014) Akiko Satoh et al.   AGING CELL

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK

(2014) S. Dai et al.   EMBO JOURNAL

Defective Regulation of the Ubiquitin/Proteasome System in the Hypothalamus of Obese Male Mice

(2014) Leticia M. Ignacio-Souza et al.   ENDOCRINOLOGY

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Atypical transforming growth factor–β signaling in the hypothalamus is linked to diabetes

(2014) Eliana P Araujo et al.   NATURE MEDICINE

Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response

(2014) Jingqi Yan et al.   NATURE MEDICINE

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preface

(2014) G. Ristic   RADIATION PROTECTION DOSIMETRY

Targeting autophagy in neurodegenerative diseases

(2014) René L. Vidal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction

(2014) Takuya Chiba et al.   Scientific Reports

mTOR signaling and its roles in normal and abnormal brain development

(2014) Nobuyuki Takei et al.   Frontiers in Molecular Neuroscience

Salicylate (Salsalate) in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Evolution of the unfolded protein response

(2013) Julie Hollien   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

(2013) Marcelo O. Dietrich et al.   CELL

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Less is more: improving proteostasis by translation slow down

(2013) Michael Y. Sherman et al.   TRENDS IN BIOCHEMICAL SCIENCES

The caloric restriction paradigm: Implications for healthy human aging

(2012) Rozalyn M. Anderson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Mitochondrial quality control by the ubiquitin–proteasome system: Figure 1

(2012) Eric B. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

(2012) Cora O'Neill et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

(2012) Bérengère Coupé et al.   Cell Metabolism

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

(2012) Susmita Kaushik et al.   EMBO REPORTS

Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review

(2012) M Valette et al.   INTERNATIONAL JOURNAL OF OBESITY

Chaperone Insufficiency Links TLR4 Protein Signaling to Endoplasmic Reticulum Stress

(2012) Andressa Coope et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR signaling in protein homeostasis

(2011) Crystal S. Conn et al.   CELL CYCLE

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Partial Reversibility of Hypothalamic Dysfunction and Changes in Brain Activity After Body Mass Reduction in Obese Subjects

(2011) S. van de Sande-Lee et al.   DIABETES

Altered hypothalamic function in diet-induced obesity

(2011) L A Velloso et al.   INTERNATIONAL JOURNAL OF OBESITY

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic approaches to understanding human obesity

(2011) Shwetha Ramachandrappa et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

(2011) Hong Wu et al.   NATURE MEDICINE

Proteomic Analysis of Rat Hypothalamus Revealed the Role of Ubiquitin–Proteasome System in the Genesis of DR or DIO

(2011) Qi-ming Wang et al.   NEUROCHEMICAL RESEARCH

Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6

(2011) S. Klinge et al.   SCIENCE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Quality Control of Mitochondrial Proteostasis

(2011) M. J. Baker et al.   Cold Spring Harbor Perspectives in Biology

The life span-prolonging effect of Sirtuin-1 is mediated by autophagy

(2010) Eugenia Morselli et al.   Autophagy

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Increased E4 Activity in Mice Leads to Ubiquitin-containing Aggregates and Degeneration of Hypothalamic Neurons Resulting in Obesity

(2010) Etsuo Susaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K-mTORC1 Attenuates Stress Response by Inhibiting Cap-independent Hsp70 Translation

(2010) Jun Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Structural and Functional Characterization of the Monomeric U-Box Domain from E4B

(2009) Kyle A. Nordquist et al.   BIOCHEMISTRY

Critical Role for Hypothalamic mTOR Activity in Energy Balance

(2009) Hiroyuki Mori et al.   Cell Metabolism

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

SIRT1: Regulation of longevity via autophagy

(2009) Antero Salminen et al.   CELLULAR SIGNALLING

Inflammation and endoplasmic reticulum stress in obesity and diabetes

(2009) G S Hotamisligil   INTERNATIONAL JOURNAL OF OBESITY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

The ubiquitin system

(2009) Deepa Nath et al.   NATURE

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond

(2009) A. Christine Könner et al.   PHYSIOLOGY & BEHAVIOR

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

(2009) Juliana C. Moraes et al.   PLoS One

Autophagy: Basic Principles and Relevance to Disease

(2008) Mondira Kundu et al.   Annual Review of Pathology-Mechanisms of Disease

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging

(2008) José M. Carrascosa et al.   EXPERIMENTAL GERONTOLOGY

UCP2 protects hypothalamic cells from TNF-α-induced damage

(2008) Giovanna R. Degasperi et al.   FEBS LETTERS

The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity

(2008) D. Cota et al.   JOURNAL OF NEUROSCIENCE

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Molecular signatures of ribosomal evolution

(2008) E. Roberts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS

Physical activity, fat intake and body fat

(2007) Annelies H.C. Goris et al.   PHYSIOLOGY & BEHAVIOR