ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts

Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

(2022) Cristina Estornut et al.   Frontiers in Pharmacology

Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2022) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

(2021) Daniel Wendisch et al.   CELL

Targeting GPCR Signaling for Idiopathic Pulmonary Fibrosis Therapies

(2020) Andrew J. Haak et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signaling

(2020) Pierre-Marie Boutanquoi et al.   EUROPEAN RESPIRATORY JOURNAL

NADPH oxidase DUOX1 sustains TGF-β1 signalling and promotes lung fibrosis

(2020) Ruy Andrade Louzada et al.   EUROPEAN RESPIRATORY JOURNAL

Exploring the proteasome system: A novel concept of proteasome inhibition and regulation

(2020) Xinyuan Wang et al.   PHARMACOLOGY & THERAPEUTICS

Occupational and environmental risk factors for idiopathic pulmonary fibrosis in Australia: case–control study

(2020) Michael J Abramson et al.   THORAX

NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis

(2020) Kosuke Kato et al.   Redox Biology

The Interplay of the Genetic Architecture, Aging, and Environmental Factors in the Pathogenesis of Idiopathic Pulmonary Fibrosis

(2020) Annie Pardo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study

(2020) Anna Duckworth et al.   Lancet Respiratory Medicine

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

(2020) Paolo Spagnolo et al.   PHARMACOLOGY & THERAPEUTICS

Deletion of Osteopontin Enhances β2-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes

(2019) Celina Pollard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NOX Enzymes and Mitochondria

(2019) Carmen Veith et al.   ANTIOXIDANTS & REDOX SIGNALING

β2-Adrenergic Receptor (ADRB2) Gene Polymorphisms and Risk of COPD Exacerbations: The Rotterdam Study

(2019) Leila Karimi et al.   Journal of Clinical Medicine

The β2-adrenergic receptor-ROS signaling axis: An overlooked component of β2AR function?

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Pharmacogenomics of GPCR Drug Targets

(2018) Alexander S. Hauser et al.   CELL

New insights into TGF-β/Smad signaling in tissue fibrosis

(2018) He-He Hu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis

(2018) Loka R. Penke et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular matrix as a driver of progressive fibrosis

(2018) Jeremy Herrera et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibrosis: Lessons from OMICS analyses of the human lung

(2018) Guoying Yu et al.   MATRIX BIOLOGY

Reducing protein oxidation reverses lung fibrosis

(2018) Vikas Anathy et al.   NATURE MEDICINE

Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic?

(2018) Paul J Wolters et al.   Lancet Respiratory Medicine

Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis

(2018) Scott M. Palmer et al.   CHEST

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

(2018) Brett A. Shook et al.   SCIENCE

Regulation of Ubiquitin Enzymes in the TGF-β Pathway

(2017) Prasanna Iyengar   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

(2017) Guoying Yu et al.   NATURE MEDICINE

Reactive oxygen species as signaling molecules in the development of lung fibrosis

(2017) Francisco J. Gonzalez-Gonzalez et al.   Translational Research

Idiopathic pulmonary fibrosis

(2017) Fernando J. Martinez et al.   Nature Reviews Disease Primers

Matrix Remodeling in Pulmonary Fibrosis and Emphysema

(2016) Tejaswini Kulkarni et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

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(2016) Kirby N Swatek et al.   CELL RESEARCH

Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways

(2016) Christopher M. Evans et al.   PHYSIOLOGICAL REVIEWS

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review

(2015) John Hutchinson et al.   EUROPEAN RESPIRATORY JOURNAL

β2-Adrenoceptor Activation Modulates Skin Wound Healing Processes to Reduce Scarring

(2015) Gabrielle S. Le Provost et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

The Mitochondrial Cardiolipin Remodeling Enzyme Lysocardiolipin Acyltransferase Is a Novel Target in Pulmonary Fibrosis

(2014) Long Shuang Huang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix Metalloproteinase-19 Promotes Metastatic BehaviorIn Vitroand Is Associated with Increased Mortality in Non–Small Cell Lung Cancer

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Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

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Matrix Metalloproteinase-19 Is a Key Regulator of Lung Fibrosis in Mice and Humans

(2012) Guoying Yu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phosphatases in SMAD regulation

(2012) David L. Bruce et al.   FEBS LETTERS

Viral Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

(2011) Sharon Chao Wootton et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

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(2011) Talmadge E King et al.   LANCET

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Course and Prediction of Survival in Idiopathic Pulmonary Fibrosis

(2010) Brett Ley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of TGF-β signalling by protein phosphatases

(2010) Ting Liu et al.   BIOCHEMICAL JOURNAL

Beta2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation

(2010) Pablo Aránguiz-Urroz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE