Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging

(2022) Adelaida R. Palla et al.   Nature Communications

GLI3 regulates muscle stem cell entry into GAlert and self-renewal

(2022) Caroline E. Brun et al.   Nature Communications

Cilia, Centrosomes and Skeletal Muscle

(2021) Dominic C. H. Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

(2020) Mi-Lang Kyun et al.   Cell Reports

Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit

(2020) Lu Yue et al.   DEVELOPMENTAL CELL

Developmental and regenerative paradigms of cilia regulated hedgehog signaling

(2020) Daniel Kopinke et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts

(2020) Nisha Venugopal et al.   BMC Molecular and Cell Biology

Involvement of Wnt signaling in primary cilia assembly and disassembly

(2020) Kyung Ho Lee   FEBS Journal

Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling

(2019) Cindy T.J. van Velthoven et al.   Cell Stem Cell

TALPID3 in Joubert syndrome and related ciliopathy disorders

(2019) Amy M Fraser et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Correction: Single cell analysis of adult mouse skeletal muscle stem cells in homeostatic and regenerative conditions (doi: 10.1242/dev.174177)

(2019) Stefania Dell'Orso et al.   DEVELOPMENT

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm

(2017) Joseph Pickering et al.   MATRIX BIOLOGY

In Situ Fixation Redefines Quiescence and Early Activation of Skeletal Muscle Stem Cells

(2017) Léo Machado et al.   Cell Reports

Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo

(2017) Cindy T.J. van Velthoven et al.   Cell Reports

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer

(2016) James A. McCubrey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Concise Review: Primary Cilia: Control Centers for Stem Cell Lineage Specification and Potential Targets for Cell-Based Therapies

(2016) Josephine C. Bodle et al.   STEM CELLS

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

β-Catenin Activation in Muscle Progenitor Cells Regulates Tissue Repair

(2016) Anja Rudolf et al.   Cell Reports

Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal

(2016) Nur Hayati Jaafar Marican et al.   Stem Cell Reports

Coordinated action of Axin1 and Axin2 suppresses β-catenin to regulate muscle stem cell function

(2015) Nicolas Figeac et al.   CELLULAR SIGNALLING

Klhl31 attenuates β-catenin dependent Wnt signaling and regulates embryo myogenesis

(2015) Alaa Abou-Elhamd et al.   DEVELOPMENTAL BIOLOGY

TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)

(2015) Louise A Stephen et al.   eLife

Wnt/β-catenin controls follistatin signalling to regulate satellite cell myogenic potential

(2015) Andrew E Jones et al.   Skeletal Muscle

The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation

(2014) Chih-Wei Fan et al.   CHEMISTRY & BIOLOGY

The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly

(2014) Tetsuo Kobayashi et al.   JOURNAL OF CELL BIOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma

(2014) W. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transiently Active Wnt/β-Catenin Signaling Is Not Required but Must Be Silenced for Stem Cell Function during Muscle Regeneration

(2014) Malea M. Murphy et al.   Stem Cell Reports

Myf5-Positive Satellite Cells Contribute to Pax7-Dependent Long-Term Maintenance of Adult Muscle Stem Cells

(2013) Stefan Günther et al.   Cell Stem Cell

Pax7 is critical for the normal function of satellite cells in adult skeletal muscle

(2013) J. von Maltzahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The myotomal basement membrane

(2013) Anne-Gaëlle Borycki   Cell Adhesion & Migration

Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation

(2012) C. Borday et al.   DEVELOPMENT

Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity

(2012) C. Anderson et al.   GENES & DEVELOPMENT

Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation

(2012) J. K.-H. Hu et al.   GENES & DEVELOPMENT

Hedgehog Signaling Regulates MyoD Expression and Activity

(2012) Anastassia Voronova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure of Wntch signalling and the resolution of transition states in development

(2012) Silvia Muñoz Descalzo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Generation of mice with functional inactivation of talpid3, a gene first identified in chicken

(2011) F. Bangs et al.   DEVELOPMENT

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells

(2010) Christoph Lepper et al.   GENESIS

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling

(2009) Pia Aanstad et al.   CURRENT BIOLOGY

The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

(2009) Y. Yin et al.   DEVELOPMENT

Sonic hedgehog-dependent synthesis of laminin  1 controls basement membrane assembly in the myotome

(2009) C. Anderson et al.   DEVELOPMENT

Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis

(2009) Muhammad Abu-Elmagd et al.   DEVELOPMENTAL BIOLOGY

A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult Myogenesis

(2008) Andrew S. Brack et al.   Cell Stem Cell

Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration

(2008) Giuseppe Straface et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Prospective Isolation of Skeletal Muscle Stem Cells with a Pax7 Reporter

(2008) Darko Bosnakovski et al.   STEM CELLS