Pursuit of a perfect insulin

One-year efficacy and safety of a fixed combination of insulin degludec and liraglutide in patients with type 2 diabetes: results of a 26-week extension to a 26-week main trial

(2015) S. C. L. Gough et al.   DIABETES OBESITY & METABOLISM

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation

(2015) Na-Oh Yunn et al.   NUCLEIC ACIDS RESEARCH

Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

(2015) Danny Hung-Chieh Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Synthetic Route to Human Insulin Using Isoacyl Peptides

(2014) Fa Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Emerging micro- and nanotechnology based synthetic approaches for insulin delivery

(2014) Ran Mo et al.   CHEMICAL SOCIETY REVIEWS

Inhaled Insulin: A Breath of Fresh Air? A Review of Inhaled Insulin

(2014) Tricia Santos Cavaiola et al.   CLINICAL THERAPEUTICS

Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity

(2014) G. Qiang et al.   DIABETES

Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog

(2014) Dale S. Edgerton et al.   DIABETES

Comparison of Insulin Degludec/Insulin Aspart and Biphasic Insulin Aspart 30 in Uncontrolled, Insulin-Treated Type 2 Diabetes: A Phase 3a, Randomized, Treat-to-Target Trial

(2014) Gregory R. Fulcher et al.   DIABETES CARE

Insulin Therapy in People With Type 2 Diabetes: Opportunities and Challenges?

(2014) Philip Home et al.   DIABETES CARE

Advancing Basal Insulin Replacement in Type 2 Diabetes Inadequately Controlled With Insulin Glargine Plus Oral Agents: A Comparison of Adding Albiglutide, a Weekly GLP-1 Receptor Agonist, Versus Thrice-Daily Prandial Insulin Lispro

(2014) Julio Rosenstock et al.   DIABETES CARE

Basal Insulin Peglispro Demonstrates Preferential Hepatic Versus Peripheral Action Relative to Insulin Glargine in Healthy Subjects

(2014) Robert R. Henry et al.   DIABETES CARE

A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADD-ON)

(2014) C. Mathieu et al.   DIABETES OBESITY & METABOLISM

Closed-Loop System in the Management of Diabetes: Past, Present, and Future

(2014) Viral N. Shah et al.   Diabetes Technology & Therapeutics

Insulin Pens and New Ways of Insulin Delivery

(2014) Lutz Heinemann   Diabetes Technology & Therapeutics

Use and Out-of-Pocket Costs of Insulin for Type 2 Diabetes Mellitus From 2000 Through 2010

(2014) Kasia J. Lipska et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects

(2014) Vikram P. Sinha et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Cell factories for insulin production

(2014) Nabih A Baeshen et al.   Microbial Cell Factories

Sanofi to propel inhalable insulin Afrezza into market

(2014) Jim Kling   NATURE BIOTECHNOLOGY

Insulin pump therapy for type 2 diabetes mellitus

(2014) John C. Pickup   Nature Reviews Endocrinology

Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes

(2014) Stephen C L Gough et al.   Lancet Diabetes & Endocrinology

Discovery of High Potency, Single-Chain Insulin Analogs with a Shortened B-Chain and Nonpeptide Linker

(2013) Zachary P. Kaur et al.   ACS Chemical Biology

Chemical Synthesis of Insulin Analogs through a Novel Precursor

(2013) Alexander N. Zaykov et al.   ACS Chemical Biology

A 7-year follow-up retrospective, international, multicenter study of insulin pump therapy in children and adolescents with type 1 diabetes

(2013) Chiara Mameli et al.   ACTA DIABETOLOGICA

Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering

(2013) Saik-Kia Goh et al.   BIOMATERIALS

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

Proinsulin-Transferrin Fusion Protein as a Novel Long-Acting Insulin Analog for the Inhibition of Hepatic Glucose Production

(2013) Yan Wang et al.   DIABETES

Combining Incretin-Based Therapies With Insulin: Realizing the potential in type 2 diabetes

(2013) J. Vora   DIABETES CARE

Lower Glucose Variability and Hypoglycemia Measured by Continuous Glucose Monitoring With Novel Long-Acting Insulin LY2605541 Versus Insulin Glargine

(2013) Richard M. Bergenstal et al.   DIABETES CARE

Contrasting weight changes with LY2605541, a novel long-acting insulin, and insulin glargine despite similar improved glycaemic control in T1DM and T2DM

(2013) S. J. Jacober et al.   DIABETES OBESITY & METABOLISM

Newer insulin analogs: advances in basal insulin replacement

(2013) Bernard Zinman   DIABETES OBESITY & METABOLISM

PEGylated insulin Lispro, (LY2605541)-a new basal insulin analogue

(2013) T. M. Caparrotta et al.   DIABETES OBESITY & METABOLISM

Variability of glucose-lowering effect as a limiting factor in optimizing basal insulin therapy: a review

(2013) J. Vora et al.   DIABETES OBESITY & METABOLISM

Hepatoselectivity and the evolution of insulin

(2013) R. Herring et al.   DIABETES OBESITY & METABOLISM

Superior glycaemic control with once-daily insulin degludec/insulin aspart versus insulin glargine in Japanese adults with type 2 diabetes inadequately controlled with oral drugs: a randomized, controlled phase 3 trial

(2013) Y. Onishi et al.   DIABETES OBESITY & METABOLISM

Basal insulin analogues in the management of diabetes mellitus: what progress have we made?

(2013) David R. Owens et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Elderly Patients with Diabetes Experience a Lower Rate of Nocturnal Hypoglycaemia with Insulin Degludec than with Insulin Glargine: A Meta-Analysis of Phase IIIa Trials

(2013) Christopher Sorli et al.   DRUGS & AGING

The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options

(2013) L Fani et al.   INTERNATIONAL JOURNAL OF OBESITY

Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography

(2013) Michal Avital-Shmilovici et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Responsive Materials for Self-Regulated Insulin Delivery

(2013) Weitai Wu et al.   MACROMOLECULAR BIOSCIENCE

FDA dashes Novo's hopes

(2013) Emma Dorey   NATURE BIOTECHNOLOGY

The use of stem cells for pancreatic regeneration in diabetes mellitus

(2013) Luc Bouwens et al.   Nature Reviews Endocrinology

Concise Synthetic Routes to Human Insulin

(2013) Fa Liu et al.   ORGANIC LETTERS

Glucose-Reducing Effect of the ORMD-0801 Oral Insulin Preparation in Patients with Uncontrolled Type 1 Diabetes: A Pilot Study

(2013) Roy Eldor et al.   PLoS One

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

(2012) Vinay Bhaskar et al.   DIABETES

Better Glycemic Control and Weight Loss With the Novel Long-Acting Basal Insulin LY2605541 Compared With Insulin Glargine in Type 1 Diabetes: A randomized, crossover study

(2012) J. Rosenstock et al.   DIABETES CARE

Insulin Degludec/Insulin Aspart Administered Once Daily at Any Meal, With Insulin Aspart at Other Meals Versus a Standard Basal-Bolus Regimen in Patients With Type 1 Diabetes: A 26-week, phase 3, randomized, open-label, treat-to-target trial

(2012) I. B. Hirsch et al.   DIABETES CARE

Combining GLP-1 receptor agonists with insulin: therapeutic rationales and clinical findings

(2012) J. J. Holst et al.   DIABETES OBESITY & METABOLISM

Short-term intensified insulin treatment in type 2 diabetes: long-term effects on β-cell function

(2012) R. Retnakaran et al.   DIABETES OBESITY & METABOLISM

Combination therapy with GLP-1 receptor agonists and basal insulin: a systematic review of the literature

(2012) R. Balena et al.   DIABETES OBESITY & METABOLISM

Insulin degludec: overview of a novel ultra long-acting basal insulin

(2012) S. C. L. Gough et al.   DIABETES OBESITY & METABOLISM

Anti-obesity drugs: past, present and future

(2012) R. J. Rodgers et al.   Disease Models & Mechanisms

Synthesis: A constructive debate

(2012) Jay D. Keasling et al.   NATURE

Insulin-Pump Therapy for Type 1 Diabetes Mellitus

(2012) John C. Pickup   NEW ENGLAND JOURNAL OF MEDICINE

Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes

(2012) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin

(2012) Ib Jonassen et al.   PHARMACEUTICAL RESEARCH

GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis

(2012) Su-Jin Kim et al.   PLoS One

Agonism and Antagonism at the Insulin Receptor

(2012) Louise Knudsen et al.   PLoS One

The role of leptin in glucose homeostasis

(2012) Heather C Denroche et al.   Journal of Diabetes Investigation

Insulin degludec as an ultralong-acting basal insulin once a day: a systematic review

(2012) Fei Wang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Receptor-isoform-selective insulin analogues give tissue-preferential effects

(2011) Sara G. Vienberg et al.   BIOCHEMICAL JOURNAL

Organization of Glucose-Responsive Systems and Their Properties

(2011) Qian Wu et al.   CHEMICAL REVIEWS

Short-Term Intensive Therapy in Newly Diagnosed Type 2 Diabetes Partially Restores Both Insulin Sensitivity and β-Cell Function in Subjects With Long-Term Remission

(2011) Yun Hu et al.   DIABETES CARE

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Closed-loop insulin delivery: from bench to clinical practice

(2011) Roman Hovorka   Nature Reviews Endocrinology

Engineering of Insulin Receptor Isoform-Selective Insulin Analogues

(2011) Tine Glendorf et al.   PLoS One

Design and Folding of [GluA4(OβThrB30)]Insulin (“Ester Insulin”): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin

(2010) Youhei Sohma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Technosphere® Insulin

(2010) Joshua J. Neumiller et al.   BIODRUGS

The Role of Basal Insulin and Glucagon-Like Peptide-1 Agonists in the Therapeutic Management of Type 2 Diabetes—A Comprehensive Review

(2010) Satish K. Garg   Diabetes Technology & Therapeutics

Timing of Meal Insulin Boluses to Achieve Optimal Postprandial Glycemic Control in Patients with Type 1 Diabetes

(2010) Erin Cobry et al.   Diabetes Technology & Therapeutics

Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: a multicentre randomised trial

(2010) Julio Rosenstock et al.   LANCET

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

(2009) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties

(2009) Barry D. Kerr et al.   BIOCHEMICAL PHARMACOLOGY

Clinical Pharmacokinetics and Pharmacodynamics of Insulin Glulisine

(2009) Reinhard H A Becker et al.   CLINICAL PHARMACOKINETICS

Oral insulin - a review of current status

(2009) Harish Iyer et al.   DIABETES OBESITY & METABOLISM

Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes

(2009) F. Smeeton et al.   DIABETOLOGIA

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Insulin pumps: from inception to the present and toward the future

(2009) F. M. Alsaleh et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Total Synthesis of desB30 Insulin Analogues by Biomimetic Folding of Single-Chain Precursors

(2008) A. Pernille Tofteng et al.   CHEMBIOCHEM

Design of an Active Ultrastable Single-chain Insulin Analog

(2008) Qing-xin Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY