标题
Pursuit of a perfect insulin
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 15, Issue 6, Pages 425-439
出版商
Springer Nature
发表日期
2016-03-18
DOI
10.1038/nrd.2015.36
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- One-year efficacy and safety of a fixed combination of insulin degludec and liraglutide in patients with type 2 diabetes: results of a 26-week extension to a 26-week main trial
- (2015) S. C. L. Gough et al. DIABETES OBESITY & METABOLISM
- Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation
- (2015) Na-Oh Yunn et al. NUCLEIC ACIDS RESEARCH
- Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates
- (2015) Danny Hung-Chieh Chou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Synthetic Route to Human Insulin Using Isoacyl Peptides
- (2014) Fa Liu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Generation of Functional Human Pancreatic β Cells In Vitro
- (2014) Felicia W. Pagliuca et al. CELL
- Emerging micro- and nanotechnology based synthetic approaches for insulin delivery
- (2014) Ran Mo et al. CHEMICAL SOCIETY REVIEWS
- Inhaled Insulin: A Breath of Fresh Air? A Review of Inhaled Insulin
- (2014) Tricia Santos Cavaiola et al. CLINICAL THERAPEUTICS
- Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity
- (2014) G. Qiang et al. DIABETES
- Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog
- (2014) Dale S. Edgerton et al. DIABETES
- Comparison of Insulin Degludec/Insulin Aspart and Biphasic Insulin Aspart 30 in Uncontrolled, Insulin-Treated Type 2 Diabetes: A Phase 3a, Randomized, Treat-to-Target Trial
- (2014) Gregory R. Fulcher et al. DIABETES CARE
- Insulin Therapy in People With Type 2 Diabetes: Opportunities and Challenges?
- (2014) Philip Home et al. DIABETES CARE
- Advancing Basal Insulin Replacement in Type 2 Diabetes Inadequately Controlled With Insulin Glargine Plus Oral Agents: A Comparison of Adding Albiglutide, a Weekly GLP-1 Receptor Agonist, Versus Thrice-Daily Prandial Insulin Lispro
- (2014) Julio Rosenstock et al. DIABETES CARE
- Basal Insulin Peglispro Demonstrates Preferential Hepatic Versus Peripheral Action Relative to Insulin Glargine in Healthy Subjects
- (2014) Robert R. Henry et al. DIABETES CARE
- A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADD-ON)
- (2014) C. Mathieu et al. DIABETES OBESITY & METABOLISM
- Closed-Loop System in the Management of Diabetes: Past, Present, and Future
- (2014) Viral N. Shah et al. Diabetes Technology & Therapeutics
- Insulin Pens and New Ways of Insulin Delivery
- (2014) Lutz Heinemann Diabetes Technology & Therapeutics
- Use and Out-of-Pocket Costs of Insulin for Type 2 Diabetes Mellitus From 2000 Through 2010
- (2014) Kasia J. Lipska et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects
- (2014) Vikram P. Sinha et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Cell factories for insulin production
- (2014) Nabih A Baeshen et al. Microbial Cell Factories
- Sanofi to propel inhalable insulin Afrezza into market
- (2014) Jim Kling NATURE BIOTECHNOLOGY
- Insulin pump therapy for type 2 diabetes mellitus
- (2014) John C. Pickup Nature Reviews Endocrinology
- Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes
- (2014) Stephen C L Gough et al. Lancet Diabetes & Endocrinology
- Discovery of High Potency, Single-Chain Insulin Analogs with a Shortened B-Chain and Nonpeptide Linker
- (2013) Zachary P. Kaur et al. ACS Chemical Biology
- Chemical Synthesis of Insulin Analogs through a Novel Precursor
- (2013) Alexander N. Zaykov et al. ACS Chemical Biology
- A 7-year follow-up retrospective, international, multicenter study of insulin pump therapy in children and adolescents with type 1 diabetes
- (2013) Chiara Mameli et al. ACTA DIABETOLOGICA
- Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering
- (2013) Saik-Kia Goh et al. BIOMATERIALS
- An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
- (2013) William L. Holland et al. Cell Metabolism
- Proinsulin-Transferrin Fusion Protein as a Novel Long-Acting Insulin Analog for the Inhibition of Hepatic Glucose Production
- (2013) Yan Wang et al. DIABETES
- Combining Incretin-Based Therapies With Insulin: Realizing the potential in type 2 diabetes
- (2013) J. Vora DIABETES CARE
- Lower Glucose Variability and Hypoglycemia Measured by Continuous Glucose Monitoring With Novel Long-Acting Insulin LY2605541 Versus Insulin Glargine
- (2013) Richard M. Bergenstal et al. DIABETES CARE
- Contrasting weight changes with LY2605541, a novel long-acting insulin, and insulin glargine despite similar improved glycaemic control in T1DM and T2DM
- (2013) S. J. Jacober et al. DIABETES OBESITY & METABOLISM
- Newer insulin analogs: advances in basal insulin replacement
- (2013) Bernard Zinman DIABETES OBESITY & METABOLISM
- PEGylated insulin Lispro, (LY2605541)-a new basal insulin analogue
- (2013) T. M. Caparrotta et al. DIABETES OBESITY & METABOLISM
- Variability of glucose-lowering effect as a limiting factor in optimizing basal insulin therapy: a review
- (2013) J. Vora et al. DIABETES OBESITY & METABOLISM
- Hepatoselectivity and the evolution of insulin
- (2013) R. Herring et al. DIABETES OBESITY & METABOLISM
- Superior glycaemic control with once-daily insulin degludec/insulin aspart versus insulin glargine in Japanese adults with type 2 diabetes inadequately controlled with oral drugs: a randomized, controlled phase 3 trial
- (2013) Y. Onishi et al. DIABETES OBESITY & METABOLISM
- Basal insulin analogues in the management of diabetes mellitus: what progress have we made?
- (2013) David R. Owens et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Elderly Patients with Diabetes Experience a Lower Rate of Nocturnal Hypoglycaemia with Insulin Degludec than with Insulin Glargine: A Meta-Analysis of Phase IIIa Trials
- (2013) Christopher Sorli et al. DRUGS & AGING
- The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options
- (2013) L Fani et al. INTERNATIONAL JOURNAL OF OBESITY
- Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography
- (2013) Michal Avital-Shmilovici et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Responsive Materials for Self-Regulated Insulin Delivery
- (2013) Weitai Wu et al. MACROMOLECULAR BIOSCIENCE
- FDA dashes Novo's hopes
- (2013) Emma Dorey NATURE BIOTECHNOLOGY
- The use of stem cells for pancreatic regeneration in diabetes mellitus
- (2013) Luc Bouwens et al. Nature Reviews Endocrinology
- Concise Synthetic Routes to Human Insulin
- (2013) Fa Liu et al. ORGANIC LETTERS
- Glucose-Reducing Effect of the ORMD-0801 Oral Insulin Preparation in Patients with Uncontrolled Type 1 Diabetes: A Pilot Study
- (2013) Roy Eldor et al. PLoS One
- Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans
- (2013) B. Finan et al. Science Translational Medicine
- A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control
- (2012) Vinay Bhaskar et al. DIABETES
- Better Glycemic Control and Weight Loss With the Novel Long-Acting Basal Insulin LY2605541 Compared With Insulin Glargine in Type 1 Diabetes: A randomized, crossover study
- (2012) J. Rosenstock et al. DIABETES CARE
- Insulin Degludec/Insulin Aspart Administered Once Daily at Any Meal, With Insulin Aspart at Other Meals Versus a Standard Basal-Bolus Regimen in Patients With Type 1 Diabetes: A 26-week, phase 3, randomized, open-label, treat-to-target trial
- (2012) I. B. Hirsch et al. DIABETES CARE
- Combining GLP-1 receptor agonists with insulin: therapeutic rationales and clinical findings
- (2012) J. J. Holst et al. DIABETES OBESITY & METABOLISM
- Short-term intensified insulin treatment in type 2 diabetes: long-term effects on β-cell function
- (2012) R. Retnakaran et al. DIABETES OBESITY & METABOLISM
- Combination therapy with GLP-1 receptor agonists and basal insulin: a systematic review of the literature
- (2012) R. Balena et al. DIABETES OBESITY & METABOLISM
- Insulin degludec: overview of a novel ultra long-acting basal insulin
- (2012) S. C. L. Gough et al. DIABETES OBESITY & METABOLISM
- Anti-obesity drugs: past, present and future
- (2012) R. J. Rodgers et al. Disease Models & Mechanisms
- Synthesis: A constructive debate
- (2012) Jay D. Keasling et al. NATURE
- Insulin-Pump Therapy for Type 1 Diabetes Mellitus
- (2012) John C. Pickup NEW ENGLAND JOURNAL OF MEDICINE
- Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
- (2012) Philip R. Schauer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin
- (2012) Ib Jonassen et al. PHARMACEUTICAL RESEARCH
- GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis
- (2012) Su-Jin Kim et al. PLoS One
- Agonism and Antagonism at the Insulin Receptor
- (2012) Louise Knudsen et al. PLoS One
- The role of leptin in glucose homeostasis
- (2012) Heather C Denroche et al. Journal of Diabetes Investigation
- Insulin degludec as an ultralong-acting basal insulin once a day: a systematic review
- (2012) Fei Wang et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Receptor-isoform-selective insulin analogues give tissue-preferential effects
- (2011) Sara G. Vienberg et al. BIOCHEMICAL JOURNAL
- Organization of Glucose-Responsive Systems and Their Properties
- (2011) Qian Wu et al. CHEMICAL REVIEWS
- Short-Term Intensive Therapy in Newly Diagnosed Type 2 Diabetes Partially Restores Both Insulin Sensitivity and β-Cell Function in Subjects With Long-Term Remission
- (2011) Yun Hu et al. DIABETES CARE
- Signalling by insulin and IGF receptors: supporting acts and new players
- (2011) Kenneth Siddle JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Closed-loop insulin delivery: from bench to clinical practice
- (2011) Roman Hovorka Nature Reviews Endocrinology
- Engineering of Insulin Receptor Isoform-Selective Insulin Analogues
- (2011) Tine Glendorf et al. PLoS One
- Design and Folding of [GluA4(OβThrB30)]Insulin (“Ester Insulin”): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin
- (2010) Youhei Sohma et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Technosphere® Insulin
- (2010) Joshua J. Neumiller et al. BIODRUGS
- The Role of Basal Insulin and Glucagon-Like Peptide-1 Agonists in the Therapeutic Management of Type 2 Diabetes—A Comprehensive Review
- (2010) Satish K. Garg Diabetes Technology & Therapeutics
- Timing of Meal Insulin Boluses to Achieve Optimal Postprandial Glycemic Control in Patients with Type 1 Diabetes
- (2010) Erin Cobry et al. Diabetes Technology & Therapeutics
- Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: a multicentre randomised trial
- (2010) Julio Rosenstock et al. LANCET
- Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects
- (2009) Jing Xu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties
- (2009) Barry D. Kerr et al. BIOCHEMICAL PHARMACOLOGY
- Clinical Pharmacokinetics and Pharmacodynamics of Insulin Glulisine
- (2009) Reinhard H A Becker et al. CLINICAL PHARMACOKINETICS
- Oral insulin - a review of current status
- (2009) Harish Iyer et al. DIABETES OBESITY & METABOLISM
- Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes
- (2009) F. Smeeton et al. DIABETOLOGIA
- Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease
- (2009) Antonino Belfiore et al. ENDOCRINE REVIEWS
- Insulin pumps: from inception to the present and toward the future
- (2009) F. M. Alsaleh et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Total Synthesis of desB30 Insulin Analogues by Biomimetic Folding of Single-Chain Precursors
- (2008) A. Pernille Tofteng et al. CHEMBIOCHEM
- Design of an Active Ultrastable Single-chain Insulin Analog
- (2008) Qing-xin Hua et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now