Regulation of the proteostasis network by the neuronal system

Transcellular chaperone signaling is an intercellular stress-response distinct from the HSF-1–mediated heat shock response

(2023) Jay Miles et al.   PLOS BIOLOGY

Side effects loom over Alzheimer’s drugs

(2023) Jennifer Couzin-Frankel   SCIENCE

Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults

(2022) Hana Boocholez et al.   Cell Reports

Gonadotropin-releasing hormone-like receptor 2 inversely regulates somatic proteostasis and reproduction in Caenorhabditis elegans

(2022) Mor Kishner et al.   Frontiers in Cell and Developmental Biology

Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans

(2021) Giuseppe Calculli et al.   Science Advances

Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer’s Disease Mice

(2020) Jing Ma et al.   Current Alzheimer Research

Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans

(2020) Ashley E. Frakes et al.   SCIENCE

Organismal Protein Homeostasis Mechanisms

(2020) Thorsten Hoppe et al.   GENETICS

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Functional Modules of the Proteostasis Network

(2019) Gopal G. Jayaraj et al.   Cold Spring Harbor Perspectives in Biology

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease

(2019) Richard I. Morimoto   Cold Spring Harbor Perspectives in Biology

Modulation of caveolae by insulin/IGF‐1 signaling regulates aging of Caenorhabditis elegans

(2018) Noa Roitenberg et al.   EMBO REPORTS

A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis

(2018) Daniel O’Brien et al.   Cell Reports

The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans

(2018) Lorna Moll et al.   eLife

The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition

(2016) Lorna Moll et al.   FASEB JOURNAL

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

(2015) Andreia Teixeira-Castro et al.   BRAIN

Neuronal Serotonin Release Triggers the Heat Shock Response in C. elegans in the Absence of Temperature Increase

(2015) Marcus C. Tatum et al.   CURRENT BIOLOGY

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

The nematode Caenorhabditis elegans: A versatile model for the study of proteotoxicity and aging

(2014) Yuli Volovik et al.   METHODS

Differential Regulation of the Heat Shock Factor 1 and DAF-16 by Neuronal nhl-1 in the Nematode C. elegans

(2014) Yuli Volovik et al.   Cell Reports

Germline stem cell arrest inhibits the collapse of somatic proteostasis early inCaenorhabditis elegansadulthood

(2013) Netta Shemesh et al.   AGING CELL

A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity

(2013) Tayir El-Ami et al.   AGING CELL

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

A Neuronal GPCR is Critical for the Induction of the Heat Shock Response in the Nematode C. elegans

(2013) M. Maman et al.   JOURNAL OF NEUROSCIENCE

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

(2013) Maria A. Ermolaeva et al.   NATURE

Ataxin-3 and Its E3 Partners: Implications for Machado–Joseph Disease

(2013) Thomas M. Durcan et al.   Frontiers in Neurology

Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins

(2011) V. Prahlad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans

(2010) Roongpetch Keowkase et al.   NEUROPHARMACOLOGY

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL