Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults

Global Transcriptome Changes That Accompany Alterations in Serotonin Levels in Caenorhabditis elegans

(2020) Johnny Cruz-Corchado et al.   G3-Genes Genomes Genetics

Organismal Protein Homeostasis Mechanisms

(2020) Thorsten Hoppe et al.   GENETICS

Extracellular proteostasis prevents aggregation during pathogenic attack

(2020) Ivan Gallotta et al.   NATURE

Functional Modules of the Proteostasis Network

(2019) Gopal G. Jayaraj et al.   Cold Spring Harbor Perspectives in Biology

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans

(2019) Soudabeh Imanikia et al.   CURRENT BIOLOGY

Gene expression modulation by the linker of nucleoskeleton and cytoskeleton complex contributes to proteostasis

(2019) Amir Levine et al.   AGING CELL

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Modulation of caveolae by insulin/IGF‐1 signaling regulates aging of Caenorhabditis elegans

(2018) Noa Roitenberg et al.   EMBO REPORTS

Monoamines differentially modulate neuropeptide release from distinct sites within a single neuron pair

(2018) Tobias Clark et al.   PLoS One

An atlas of Caenorhabditis elegans chemoreceptor expression

(2018) Berta Vidal et al.   PLOS BIOLOGY

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling

(2018) Tesfahun Dessale Admasu et al.   DEVELOPMENTAL CELL

Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in Caenorhabditis elegans via the receptor SEB-3

(2018) Yee Lian Chew et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans

(2018) Lorna Moll et al.   eLife

Comprehensive single-cell transcriptional profiling of a multicellular organism

(2017) Junyue Cao et al.   SCIENCE

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

Torsins Are Essential Regulators of Cellular Lipid Metabolism

(2016) Micheline Grillet et al.   DEVELOPMENTAL CELL

The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition

(2016) Lorna Moll et al.   FASEB JOURNAL

GAM: a web-service for integrated transcriptional and metabolic network analysis

(2016) Alexey A. Sergushichev et al.   NUCLEIC ACIDS RESEARCH

A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans

(2016) Yael Bar-Lavan et al.   PLoS Genetics

The Roles of Cellular and Organismal Aging in the Development of Late-Onset Maladies

(2015) Filipa Carvalhal Marques et al.   Annual Review of Pathology-Mechanisms of Disease

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

(2015) Andreia Teixeira-Castro et al.   BRAIN

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS)

(2015) Timur A. Mavlyutov et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

(2015) Michael J Steinbaugh et al.   eLife

The nematode Caenorhabditis elegans: A versatile model for the study of proteotoxicity and aging

(2014) Yuli Volovik et al.   METHODS

Differential Regulation of the Heat Shock Factor 1 and DAF-16 by Neuronal nhl-1 in the Nematode C. elegans

(2014) Yuli Volovik et al.   Cell Reports

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity

(2013) Tayir El-Ami et al.   AGING CELL

The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types

(2013) F. Zhang et al.   DEVELOPMENT

Neuropeptides Amplify and Focus the Monoaminergic Inhibition of Nociception in Caenorhabditis elegans

(2013) V. Hapiak et al.   JOURNAL OF NEUROSCIENCE

A Neuronal GPCR is Critical for the Induction of the Heat Shock Response in the Nematode C. elegans

(2013) M. Maman et al.   JOURNAL OF NEUROSCIENCE

HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity

(2012) Wei-Chung Chiang et al.   CELL

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Neuropeptide GPCRs in C. elegans

(2012) Lotte Frooninckx et al.   Frontiers in Endocrinology

EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan

(2011) Gang Liu et al.   EMBO JOURNAL

Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins

(2011) V. Prahlad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal GPCR Controls Innate Immunity by Regulating Noncanonical Unfolded Protein Response Genes

(2011) J. Sun et al.   SCIENCE

Enhanced neuronal RNAi in C. elegans using SID-1

(2010) Andrea Calixto et al.   NATURE METHODS

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer’s disease

(2009) Susanna Freude et al.   FASEB JOURNAL

The Caenorhabditis elegans Aβ1–42Model of Alzheimer Disease Predominantly Expresses Aβ3–42

(2009) Gawain McColl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

(2009) Tali Gidalevitz et al.   PLoS Genetics

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE