Transcellular chaperone signaling is an intercellular stress-response distinct from the HSF-1–mediated heat shock response

Glia of C. elegans coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit

(2022) Holly K. Gildea et al.   Science Advances

The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones

(2021) Netta Shemesh et al.   Nature Communications

Gut microbiome differences between amyotrophic lateral sclerosis patients and spouse controls

(2021) Vicki S. Hertzberg et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Neuropod Cells: Emerging Biology of the Gut-Brain Sensory Transduction

(2020) Melanie Maya Kaelberer et al.   Annual Review of Neuroscience

Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans

(2020) Ashley E. Frakes et al.   SCIENCE

Serotonin signaling by maternal neurons upon stress ensures progeny survival

(2020) Srijit Das et al.   eLife

Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster

(2020) Parvathy Venugopal et al.   BMC DEVELOPMENTAL BIOLOGY

A neurotransmitter produced by gut bacteria modulates host sensory behaviour

(2020) Michael P. O’Donnell et al.   NATURE

Extracellular proteostasis prevents aggregation during pathogenic attack

(2020) Ivan Gallotta et al.   NATURE

Bacteria-derived metabolite, methylglyoxal, modulates the longevity ofC. elegansthrough TORC2/SGK-1/DAF-16 signaling

(2020) Min-Gi Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans

(2020) Neşem P. Özbey et al.   DEVELOPMENTAL CELL

Heat stress activates YAP/TAZ to induce the heat shock transcriptome

(2020) Min Luo et al.   NATURE CELL BIOLOGY

Dietary restriction and gonadal signaling differentially regulate post-development quality control functions in Caenorhabditis elegans

(2019) Nufar Shpigel et al.   AGING CELL

The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans

(2019) Nicholas D. Peterson et al.   PLoS Genetics

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

(2019) Georges E. Janssens et al.   Cell Reports

Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans

(2019) Soudabeh Imanikia et al.   CURRENT BIOLOGY

Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response

(2019) Jay Miles et al.   TRENDS IN BIOCHEMICAL SCIENCES

Analysis of the Gut Microflora in Patients With Parkinson's Disease

(2019) Miao Jin et al.   Frontiers in Neuroscience

A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis

(2018) Daniel O’Brien et al.   Cell Reports

A systematic atlas of chaperome deregulation topologies across the human cancer landscape

(2018) Ali Hadizadeh Esfahani et al.   PLoS Computational Biology

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

DAF-21/Hsp90 is required for C. elegans longevity by ensuring DAF-16/FOXO isoform A function

(2018) Milán Somogyvári et al.   Scientific Reports

Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes

(2017) Julia Eckl et al.   PLoS One

Comprehensive single-cell transcriptional profiling of a multicellular organism

(2017) Junyue Cao et al.   SCIENCE

The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans

(2016) Jessica Brunquell et al.   BMC GENOMICS

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

Local and long-range activation of innate immunity by infection and damage in C. elegans

(2016) Jonathan J. Ewbank et al.   CURRENT OPINION IN IMMUNOLOGY

Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling

(2016) Jinwei Zhu et al.   NATURE REVIEWS NEUROSCIENCE

OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research

(2016) Seong Kyu Han et al.   Oncotarget

The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective

(2016) Madhusudana Rao Chikka et al.   Cell Reports

The Multilayer Connectome of Caenorhabditis elegans

(2016) Barry Bentley et al.   PLoS Computational Biology

Neuronal Serotonin Release Triggers the Heat Shock Response in C. elegans in the Absence of Temperature Increase

(2015) Marcus C. Tatum et al.   CURRENT BIOLOGY

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities

(2015) Kamesh Narasimhan et al.   eLife

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

Spatial and temporal organization of signaling pathways

(2014) Benjamin E. Housden et al.   TRENDS IN BIOCHEMICAL SCIENCES

Differential Regulation of the Heat Shock Factor 1 and DAF-16 by Neuronal nhl-1 in the Nematode C. elegans

(2014) Yuli Volovik et al.   Cell Reports

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity

(2013) Ronald G. Tepper et al.   CELL

Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling

(2013) Patricija van Oosten-Hawle et al.   CELL

Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators

(2013) Peichuan Zhang et al.   Cell Metabolism

Identification of a Tissue-Selective Heat Shock Response Regulatory Network

(2013) Eric Guisbert et al.   PLoS Genetics

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

CloudMap: A Cloud-Based Pipeline for Analysis of Mutant Genome Sequences

(2012) Gregory Minevich et al.   GENETICS

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

Downregulation of the Hsp90 System Causes Defects in Muscle Cells of Caenorhabditis Elegans

(2011) Andreas M. Gaiser et al.   PLoS One

Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins

(2011) V. Prahlad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding

(2010) Nicolas Lenfant et al.   BMC GENOMICS

Enhanced neuronal RNAi in C. elegans using SID-1

(2010) Andrea Calixto et al.   NATURE METHODS

C. elegans Mutant Identification with a One-Step Whole-Genome-Sequencing and SNP Mapping Strategy

(2010) Maria Doitsidou et al.   PLoS One

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons

(2008) V. Prahlad et al.   SCIENCE