Enhancing isoprenol production by systematically tuning metabolic pathways using CRISPR interference in E. coli

Targeted and high-throughput gene knockdown in diverse bacteria using synthetic sRNAs

(2023) Jae Sung Cho et al.   Nature Communications

Tuning a high performing multiplexed-CRISPRi Pseudomonas putida strain to further enhance indigoidine production

(2022) Jeffrey J. Czajka et al.   Metabolic Engineering Communications

The impact of genetic diversity on gene essentiality within the Escherichia coli species

(2021) François Rousset et al.   Nature Microbiology

Microbial production of advanced biofuels

(2021) Jay Keasling et al.   NATURE REVIEWS MICROBIOLOGY

Production Cost and Carbon Footprint of Biomass-Derived Dimethylcyclooctane as a High-Performance Jet Fuel Blendstock

(2021) Nawa Raj Baral et al.   ACS Sustainable Chemistry & Engineering

Application of different types of CRISPR/Cas-based systems in bacteria

(2020) Zhenquan Liu et al.   Microbial Cell Factories

Redirecting Metabolic Flux via Combinatorial Multiplex CRISPRi-Mediated Repression for Isopentenol Production in Escherichia coli

(2019) Tian Tian et al.   ACS Synthetic Biology

Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis

(2019) Rakesh K. Dhiman et al.   PLoS One

Optimization of the IPP-bypass mevalonate pathway and fed-batch fermentation for the production of isoprenol in Escherichia coli

(2019) Aram Kang et al.   METABOLIC ENGINEERING

Applications of CRISPR/Cas System to Bacterial Metabolic Engineering

(2018) Suhyung Cho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli

(2018) Kevin W. George et al.   METABOLIC ENGINEERING

The Essential Genome of Escherichia coli K-12

(2018) Emily C. A. Goodall et al.   mBio

Metabolic engineering of Escherichia coli for production of mixed isoprenoid alcohols and their derivatives

(2018) Bakht Zada et al.   Biotechnology for Biofuels

Regulation of ATP levels in Escherichia coli using CRISPR interference for enhanced pinocembrin production

(2018) Sha Tao et al.   Microbial Cell Factories

Efficient de novo synthesis of resveratrol by metabolically engineered Escherichia coli

(2017) Junjun Wu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

High-throughput enzyme screening platform for the IPP-bypass mevalonate pathway for isopentenol production

(2017) Aram Kang et al.   METABOLIC ENGINEERING

CRISPR interference-guided multiplex repression of endogenous competing pathway genes for redirecting metabolic flux in Escherichia coli

(2017) Seong Keun Kim et al.   Microbial Cell Factories

CRISPR interference-guided balancing of a biosynthetic mevalonate pathway increases terpenoid production

(2016) Seong Keun Kim et al.   METABOLIC ENGINEERING

Isopentenyl diphosphate (IPP)-bypass mevalonate pathways for isopentenol production

(2016) Aram Kang et al.   METABOLIC ENGINEERING

Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering

(2015) Joris Beld et al.   Molecular BioSystems

Systems strategies for developing industrial microbial strains

(2015) Sang Yup Lee et al.   NATURE BIOTECHNOLOGY

Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli

(2015) Junjun Wu et al.   Scientific Reports

Metabolic engineering for the high-yield production of isoprenoid-based C5 alcohols in E. coli

(2015) Kevin W. George et al.   Scientific Reports

Rapid editing and evolution of bacterial genomes using libraries of synthetic DNA

(2014) Ryan R Gallagher et al.   Nature Protocols

Improving Microbial Biogasoline Production in Escherichia coli Using Tolerance Engineering

(2014) Jee Loon Foo et al.   mBio

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

(2013) David Bikard et al.   NUCLEIC ACIDS RESEARCH

Metabolic engineering of menaquinone-8 pathway of Escherichia coli as a microbial platform for vitamin K production

(2011) Min Kyung Kong et al.   BIOTECHNOLOGY AND BIOENGINEERING

Programming cells by multiplex genome engineering and accelerated evolution

(2009) Harris H. Wang et al.   NATURE

Uncovering the gene knockout landscape for improved lycopene production in E. coli

(2008) Hal Alper et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY