CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury

A Salivary Gland Resident Macrophage Subset Regulating Radiation Responses

(2023) Q. Zhao et al.   JOURNAL OF DENTAL RESEARCH

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

(2023) Stephan Culemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands

(2022) Lu Lu et al.   Scientific Reports

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

(2022) Sarah A. Dick et al.   Science Immunology

The roles of CC chemokines in response to radiation

(2022) Lei Wang et al.   Radiation Oncology

Characterization of Transgenic NSG-SGM3 Mouse Model of Precision Radiation-Induced Chronic Hyposalivation

(2022) Syed Mohammed Musheer Aalam et al.   RADIATION RESEARCH

Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel

(2022) Jianlong Li et al.   Science Advances

Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

(2021) Kevin Mulder et al.   IMMUNITY

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation

(2021) Sahar Keshvari et al.   PLoS Genetics

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

(2020) Helena Aegerter et al.   NATURE IMMUNOLOGY

Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance

(2020) Bettina Stolp et al.   Science Immunology

Galectin-3 Identifies a Subset of Macrophages With a Potential Beneficial Role in Atherosclerosis

(2020) Karina Di Gregoli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transient activation of the Hedgehog-Gli pathway rescues radiotherapy-induced dry mouth via recovering salivary gland resident macrophages

(2020) Qingguo Zhao et al.   CANCER RESEARCH

SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data

(2020) Matthew D Young et al.   GigaScience

Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland Development

(2020) Belinda R. Hauser et al.   iScience

Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

(2019) Geetika Bajpai et al.   CIRCULATION RESEARCH

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

(2019) Svetoslav Chakarov et al.   SCIENCE

Fetal origin confers radio-resistance on liver macrophages via p21cip1/WAF1

(2019) Radika Soysa et al.   JOURNAL OF HEPATOLOGY

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

(2019) Rocío Rojo et al.   Nature Communications

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

(2019) Zhaoyuan Liu et al.   CELL

Injury Activates a Dynamic Cytoprotective Network to Confer Stress Resilience and Drive Repair

(2019) Helen Weavers et al.   CURRENT BIOLOGY

Salivary glands regenerate after radiation injury through SOX2‐mediated secretory cell replacement

(2018) Elaine Emmerson et al.   EMBO Molecular Medicine

Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells

(2018) Rebecca Gentek et al.   IMMUNITY

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

(2018) Tovah N. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

(2018) Sebastiaan De Schepper et al.   CELL

Genetic and scRNA-seq Analysis Reveals Distinct Cell Populations that Contribute to Salivary Gland Development and Maintenance

(2018) Eun-Ah Christine Song et al.   Scientific Reports

Macrophages in radiation injury: a new therapeutic target

(2018) Lydia Meziani et al.   OncoImmunology

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

(2018) Sarah A. Dick et al.   NATURE IMMUNOLOGY

Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

(2018) Anat Shemer et al.   Nature Communications

Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis

(2017) Georges Lacaud et al.   EXPERIMENTAL HEMATOLOGY

Top 10 research priorities in head and neck cancer: Results of an Alberta priority setting partnership of patients, caregivers, family members, and clinicians

(2017) Leah A. Lechelt et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis

(2017) Maria A. Stacey et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tyrosine Kinase Inhibitors Protect the Salivary Gland from Radiation Damage by Inhibiting Activation of Protein Kinase C-δ

(2017) Sten M. Wie et al.   MOLECULAR CANCER THERAPEUTICS

Barrier-tissue macrophages: functional adaptation to environmental challenges

(2017) Allan McI Mowat et al.   NATURE MEDICINE

SOX2 regulates acinar cell development in the salivary gland

(2017) Elaine Emmerson et al.   eLife

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells

(2016) Xiaodi Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ −/− mice causes alveolar macrophage deficiency and fatal respiratory viral infection

(2016) Christoph Schneider et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

(2016) Calum C. Bain et al.   Nature Communications

Salivary Gland Homeostasis Is Maintained through Acinar Cell Self-Duplication

(2015) Marit H. Aure et al.   DEVELOPMENTAL CELL

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation

(2015) Jeremy G Price et al.   NATURE IMMUNOLOGY

CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

(2015) Emma C. Mackley et al.   Nature Communications

Salivary gland development and disease

(2015) Aaron Mattingly et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

(2014) Paul Andrew Muller et al.   CELL

Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix

(2014) Leila Akkari et al.   GENES & DEVELOPMENT

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Regulation of Alternative Macrophage Activation by Galectin-3

(2014) A. C. MacKinnon et al.   JOURNAL OF IMMUNOLOGY

Salivary gland resident APCs are Flt3L- and CCR2-independent macrophage-like cells incapable of cross-presentation

(2013) Jenny T. Thom et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells

(2013) Gretchen E. Diehl et al.   NATURE

Role of 53BP1 in the Regulation of DNA Double-Strand Break Repair Pathway Choice

(2013) Arun Gupta et al.   RADIATION RESEARCH

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis

(2012) Samira Tamoutounour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

CD117+CD3−CD56−OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues

(2011) Soochan Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

(2011) Daigo Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restoration of radiation therapy-induced salivary gland dysfunction in mice by post therapy IGF-1 administration

(2010) Oliver Grundmann et al.   BMC CANCER

DAP12 Is Required for Macrophage Recruitment to the Lung in Response to Cigarette Smoke and Chemotaxis toward CCL2

(2010) L. L. Koth et al.   JOURNAL OF IMMUNOLOGY

Rescue of Salivary Gland Function after Stem Cell Transplantation in Irradiated Glands

(2008) Isabelle M. A. Lombaert et al.   PLoS One