The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy
Authors
Keywords
-
Journal
Lancet Gastroenterology & Hepatology
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2023-10-20
DOI
10.1016/s2468-1253(23)00207-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
- (2023) Gaopeng Li et al. CANCER CELL
- The emerging roles of γδ T cells in cancer immunotherapy
- (2023) Sofia Mensurado et al. Nature Reviews Clinical Oncology
- Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer
- (2023) Chiara Falcomatà et al. Cancer Discovery
- GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia
- (2023) Ja Young Kim-Muller et al. Cell Reports
- Spatially Resolved Multi-Omics Single-Cell Analyses Inform Mechanisms of Immune Dysfunction in Pancreatic Cancer
- (2023) Suhail Yousuf et al. GASTROENTEROLOGY
- Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
- (2023) Zhennan Yuan et al. Molecular Cancer
- Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
- (2023) Dongsung Kim et al. NATURE
- Programmable protein delivery with a bacterial contractile injection system
- (2023) Joseph Kreitz et al. NATURE
- Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
- (2023) Luis A. Rojas et al. NATURE
- Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance
- (2023) Yanshuo Chu et al. NATURE MEDICINE
- The extracellular matrix and the immune system: A mutually dependent relationship
- (2023) Tara E. Sutherland et al. SCIENCE
- Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment
- (2023) Gregor Werba et al. Nature Communications
- Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of pancreatic adenocarcinoma
- (2023) Charlie Saillard et al. Nature Communications
- Efficacy of immune checkpoint inhibitors in microsatellite unstable/mismatch repair-deficient advanced pancreatic adenocarcinoma: an AGEO European Cohort
- (2023) Julien Taïeb et al. EUROPEAN JOURNAL OF CANCER
- Obesity, cancer, and response to immune checkpoint inhibitors: Could the gut microbiota be the mechanistic link?
- (2023) Matthieu Delaye et al. PHARMACOLOGY & THERAPEUTICS
- Direct targeting of RAS in pancreatic ductal adenocarcinoma with RMC-6236, a first-in-class, RAS-selective, orally bioavailable, tri-complex RASMULTI(ON) inhibitor.
- (2022) W. Clay Gustafson et al. JOURNAL OF CLINICAL ONCOLOGY
- Squidpy: a scalable framework for spatial omics analysis
- (2022) Giovanni Palla et al. NATURE METHODS
- Tertiary lymphoid structures in cancer
- (2022) Ton N. Schumacher et al. SCIENCE
- Immunological Classification of Pancreatic Carcinomas to Identify Immune Index and Provide a Strategy for Patient Stratification
- (2022) Yi Chen et al. Frontiers in Immunology
- Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer
- (2022) Emma Kurz et al. CANCER CELL
- Multicellular Modelling of Difficult-to-Treat Gastrointestinal Cancers: Current Possibilities and Challenges
- (2022) Sarah K. Hakuno et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets
- (2022) Shinelle Menezes et al. JOURNAL OF PATHOLOGY
- Neoantigen quality predicts immunoediting in survivors of pancreatic cancer
- (2022) Marta Łuksza et al. NATURE
- Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer
- (2022) Rom Leidner et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ipilimumab/Nivolumab Therapy in Patients With Metastatic Pancreatic or Biliary Cancer With Homologous Recombination Deficiency Pathogenic Germline Variants
- (2022) Gretel Terrero et al. JAMA Oncology
- Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors
- (2022) Rocio Garcia-Carbonero et al. Journal for ImmunoTherapy of Cancer
- Dynamic profiling of immune microenvironment during pancreatic cancer development suggests early intervention and combination strategy of immunotherapy
- (2022) Jiaqi Yang et al. EBioMedicine
- Clinical Significance of Tumor-Infiltrating Conventional and Plasmacytoid Dendritic Cells in Pancreatic Ductal Adenocarcinoma
- (2022) Ioana Plesca et al. Cancers
- An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer
- (2022) Maryum Nisar et al. Frontiers in Oncology
- Targeting CD47/SIRPα as a therapeutic strategy, where we are and where we are headed
- (2022) Tailong Qu et al. Biomarker Research
- Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
- (2022) Yang Chen et al. CANCER CELL
- Autologous dendritic cells pulsed with allogeneic tumour cell lysate induce tumour-reactive T-cell responses in patients with pancreatic cancer: A phase I study
- (2022) S.P. Lau et al. EUROPEAN JOURNAL OF CANCER
- Overall Survival Results From the POLO Trial: A Phase III Study of Active Maintenance Olaparib Versus Placebo for Germline BRCA-Mutated Metastatic Pancreatic Cancer
- (2022) Hedy L. Kindler et al. JOURNAL OF CLINICAL ONCOLOGY
- Niraparib plus nivolumab or niraparib plus ipilimumab in patients with platinum-sensitive advanced pancreatic cancer: a randomised, phase 1b/2 trial
- (2022) Kim A Reiss et al. LANCET ONCOLOGY
- Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4
- (2022) Shuai Hao et al. BMC CANCER
- Phase 1/2 study of epacadostat in combination with durvalumab in patients with metastatic solid tumors
- (2022) Aung Naing et al. CANCER
- Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy
- (2022) Yu Fujiwara et al. CANCER TREATMENT REVIEWS
- The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma
- (2022) Daniel J. Renouf et al. Nature Communications
- Macrophages in health and disease
- (2022) Matthew D. Park et al. CELL
- A Transcriptomic-Based Tool to Predict Gemcitabine Sensitivity in Advanced Pancreatic Adenocarcinoma
- (2022) Nicolas Fraunhoffer et al. GASTROENTEROLOGY
- Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
- (2022) Jorge Luis Galeano Niño et al. NATURE
- Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer
- (2022) John H. Strickler et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer
- (2022) Samantha B. Kemp et al. Cancer Discovery
- Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
- (2021) Jiali Yu et al. NATURE MEDICINE
- Ibrutinib in combination with nab-paclitaxel and gemcitabine for first-line treatment of patients with metastatic pancreatic adenocarcinoma: phase III RESOLVE study
- (2021) M. Tempero et al. ANNALS OF ONCOLOGY
- IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions
- (2021) Gianluca Mucciolo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- KRAS drives immune evasion in a genetic model of pancreatic cancer
- (2021) Irene Ischenko et al. Nature Communications
- Microbiome and pancreatic ductal adenocarcinoma
- (2021) Annemilaï Tijeras-Raballand et al. Clinics and Research in Hepatology and Gastroenterology
- Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
- (2021) Shannon M. Liudahl et al. Cancer Discovery
- Estimated Projection of US Cancer Incidence and Death to 2040
- (2021) Lola Rahib et al. JAMA Network Open
- Modeling pancreatic cancer in mice for experimental therapeutics
- (2021) Kavita Mallya et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
- (2021) Kazuhiro Koikawa et al. CELL
- Squamousness gain defines pancreatic ductal adenocarcinoma hepatic metastases phenotype, and gemcitabine response
- (2021) Nicolas A. Fraunhoffer et al. EUROPEAN JOURNAL OF CANCER
- Pancreatic Cancer Progression in a Patient With Lynch Syndrome Receiving Immunotherapy: A Cautionary Tale
- (2021) Yifan Wang et al. Journal of the National Comprehensive Cancer Network
- Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
- (2021) Edoardo Del Poggetto et al. SCIENCE
- Exercise and the immune system: taking steps to improve responses to cancer immunotherapy
- (2021) Michael P Gustafson et al. Journal for ImmunoTherapy of Cancer
- Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Pancreatic Cancer: Systematic Review and Still-Open Questions
- (2021) Rita T. Lawlor et al. Cancers
- DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis
- (2021) Jenying Deng et al. JCI Insight
- Spatially confined sub-tumor microenvironments in pancreatic cancer
- (2021) Barbara T. Grünwald et al. CELL
- NOX4: a potential therapeutic target for pancreatic cancer and its mechanism
- (2021) Yawei Bi et al. Journal of Translational Medicine
- Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
- (2021) Christine N. Spencer et al. SCIENCE
- Interferon Genes Are Influenced by 17β-Estradiol in SLE
- (2021) Ram P. Singh et al. Frontiers in Immunology
- Pancreatic Cancer Microenvironment and Cellular Composition: Current Understandings and Therapeutic Approaches
- (2021) Linh-Huyen Truong et al. Cancers
- Clinical Impact of Molecular Subtyping of Pancreatic Cancer
- (2021) Zhou Xu et al. Frontiers in Cell and Developmental Biology
- The Effect of Smoking on the Immune Microenvironment and Immunogenicity and Its Relationship With the Prognosis of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer
- (2021) Yueqin Sun et al. Frontiers in Cell and Developmental Biology
- Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer
- (2020) Shipra Das et al. CANCER RESEARCH
- CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes
- (2020) Mirjana Efremova et al. Nature Protocols
- Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis
- (2020) Yaqing Zhang et al. Cancer Discovery
- Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
- (2020) Samarth Hegde et al. CANCER CELL
- Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
- (2020) Nathiya Muthalagu et al. Cancer Discovery
- The Effects of Obesity on Anti-Cancer Immunity and Cancer Immunotherapy
- (2020) Matthew J. Woodall et al. Cancers
- Enhancing the Efficacy of CAR T Cells in the Tumor Microenvironment of Pancreatic Cancer
- (2020) Janina Henze et al. Cancers
- Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma
- (2020) Eric Van Cutsem et al. JOURNAL OF CLINICAL ONCOLOGY
- Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer
- (2020) Yu Zhang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma
- (2020) Yunzhen Qian et al. Journal of Hematology & Oncology
- Targeting STAT3 in Cancer Immunotherapy
- (2020) Sailan Zou et al. Molecular Cancer
- Proton-driven transformable nanovaccine for cancer immunotherapy
- (2020) Ningqiang Gong et al. Nature Nanotechnology
- Cancer-Associated Fibroblasts: Accomplices in the Tumor Immune Evasion
- (2020) Marc Hilmi et al. Cancers
- Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies
- (2020) Meghan A. Cupp et al. BMC Medicine
- Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors
- (2020) Mary Ellen Molloy et al. CLINICAL CANCER RESEARCH
- Nerve fibers in the tumor microenvironment in neurotropic cancer—pancreatic cancer and cholangiocarcinoma
- (2020) Xiuxiang Tan et al. ONCOGENE
- Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy
- (2019) Thiago A. Patente et al. Frontiers in Immunology
- Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3neg regulatory CD4+ T cells in pancreatic carcinoma
- (2019) Rocky M. Barilla et al. Nature Communications
- Neutrophils escort circulating tumour cells to enable cell cycle progression
- (2019) Barbara Maria Szczerba et al. NATURE
- Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity
- (2019) Andrea Padoan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Neutrophil plasticity in the tumor microenvironment
- (2019) Morgan Giese et al. BLOOD
- Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion
- (2019) Hong Jiang et al. GUT
- STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models
- (2019) Weiqing Jing et al. Journal for ImmunoTherapy of Cancer
- Macrophages and Metabolism in the Tumor Microenvironment
- (2019) Ilio Vitale et al. Cell Metabolism
- Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy
- (2019) Magdalena Jarosz-Biej et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma
- (2019) Eileen M. O’Reilly et al. JAMA Oncology
- Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study
- (2019) Aurelien Marabelle et al. JOURNAL OF CLINICAL ONCOLOGY
- Immune therapies in pancreatic ductal adenocarcinoma: Where are we now?
- (2018) Marc Hilmi et al. WORLD JOURNAL OF GASTROENTEROLOGY
- The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression
- (2018) Smruti Pushalkar et al. Cancer Discovery
- Sexual Dimorphism of Immune Responses: A New Perspective in Cancer Immunotherapy
- (2018) Imerio Capone et al. Frontiers in Immunology
- Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
- (2018) Gang Chen et al. NATURE
- Tumor-Infiltrating NETs Predict Postsurgical Survival in Patients with Pancreatic Ductal Adenocarcinoma
- (2018) Wei Jin et al. ANNALS OF SURGICAL ONCOLOGY
- Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma
- (2018) Ujjwal Mukund Mahajan et al. GASTROENTEROLOGY
- Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features
- (2018) Francesco Puleo et al. GASTROENTEROLOGY
- Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma
- (2018) Christian U. Blank et al. NATURE MEDICINE
- Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status
- (2018) Romain Cohen et al. JAMA Oncology
- Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade
- (2018) Giuseppe Lo Russo et al. CLINICAL CANCER RESEARCH
- Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer
- (2017) Vinod P. Balachandran et al. NATURE
- Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
- (2017) Julienne L. Carstens et al. Nature Communications
- DNA Damage and Repair Biomarkers of Immunotherapy Response
- (2017) Kent W. Mouw et al. Cancer Discovery
- γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation
- (2016) Donnele Daley et al. CELL
- Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer
- (2015) N Hiraoka et al. BRITISH JOURNAL OF CANCER
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer
- (2014) N. Hartmann et al. CLINICAL CANCER RESEARCH
- Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis
- (2013) D. E. Sanford et al. CLINICAL CANCER RESEARCH
- A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice
- (2013) Bincy Philip et al. GASTROENTEROLOGY
- Oncology Meets Immunology: The Cancer-Immunity Cycle
- (2013) Daniel S. Chen et al. IMMUNITY
- Evaluation of Ipilimumab in Combination With Allogeneic Pancreatic Tumor Cells Transfected With a GM-CSF Gene in Previously Treated Pancreatic Cancer
- (2013) Dung T. Le et al. JOURNAL OF IMMUNOTHERAPY
- Pancreatic Cancer—Could It Be that Simple? A Different Context of Vulnerability
- (2009) Daniel D. Von Hoff et al. CANCER CELL
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started