标题
Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry
作者
关键词
-
出版物
Nature Chemical Biology
Volume 12, Issue 10, Pages 822-830
出版商
Springer Nature
发表日期
2016-08-15
DOI
10.1038/nchembio.2150
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- (2015) Svenja C. Mayer-Wrangowski et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Recent Progress in Design of Protein-Based Fluorescent Biosensors and Their Cellular Applications
- (2014) Tomonori Tamura et al. ACS Chemical Biology
- Relative Positioning of Classical Benzodiazepines to the γ2-Subunit of GABAA Receptors
- (2014) Simon J. Middendorp et al. ACS Chemical Biology
- High-Throughput Development of a Hybrid-Type Fluorescent Glutamate Sensor for Analysis of Synaptic Transmission
- (2014) Kenji Takikawa et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions
- (2014) Takayuki Miki et al. CHEMISTRY & BIOLOGY
- Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor
- (2013) David C. Chiara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Selective Detection of Allosteric Phosphatase Inhibitors
- (2013) Ralf Schneider et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A propofol binding site on mammalian GABAA receptors identified by photolabeling
- (2013) Grace M S Yip et al. Nature Chemical Biology
- Converting a Solvatochromic Fluorophore into a Protein-Based pH Indicator for Extreme Acidity
- (2012) Maiyun Yang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic
- (2012) Pavel Y. Savechenkov et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Semisynthetic Fluorescent Sensor Protein for Glutamate
- (2012) Matthias A. Brun et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A Fluorescent Sensor for GABA and Synthetic GABAB Receptor Ligands
- (2012) Anastasiya Masharina et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ligand-Directed Acyl Imidazole Chemistry for Labeling of Membrane-Bound Proteins on Live Cells
- (2012) Sho-hei Fujishima et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands
- (2012) Lars Richter et al. Nature Chemical Biology
- Recognition of Anesthetic Barbiturates by a Protein Binding Site: A High Resolution Structural Analysis
- (2012) Simon Oakley et al. PLoS One
- Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects
- (2011) Suengmok Cho et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Synthesis and evaluation of highly potent GABAA receptor antagonists based on gabazine (SR-95531)
- (2011) Favaad Iqbal et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts
- (2011) Hangxiang Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes
- (2011) Uwe Rudolph et al. NATURE REVIEWS DRUG DISCOVERY
- An In Vivo Fluorescent Sensor Reveals Intracellular Ins(1,3,4,5)P4Dynamics in Single Cells
- (2009) Reiko Sakaguchi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans
- (2009) J. R. Atack et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Conformation of Receptor Adopted upon Interaction with Virus Revealed by Site-Specific Fluorescence Quenchers and FRET Analysis
- (2009) Jürgen Wruss et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Semisynthetic Fluorescent Sensor Proteins Based on Self-Labeling Protein Tags
- (2009) Matthias A. Brun et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38α
- (2009) Jeffrey R. Simard et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Development of a Fluorescent-Tagged Kinase Assay System for the Detection and Characterization of Allosteric Kinase Inhibitors
- (2009) Jeffrey R. Simard et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ligand-directed tosyl chemistry for protein labeling in vivo
- (2009) Shinya Tsukiji et al. Nature Chemical Biology
- Structural Mechanisms Underlying Benzodiazepine Modulation of the GABAA Receptor
- (2008) S. M. Hanson et al. JOURNAL OF NEUROSCIENCE
- The Clustering of GABAA Receptor Subtypes at Inhibitory Synapses is Facilitated via the Direct Binding of Receptor 2 Subunits to Gephyrin
- (2008) V. Tretter et al. JOURNAL OF NEUROSCIENCE
- Recognition-Domain Focused Chemosensors: Versatile and Efficient Reporters of Protein Kinase Activity
- (2008) Elvedin Luković et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- GABAA receptors: Subtypes provide diversity of function and pharmacology
- (2008) Richard W. Olsen et al. NEUROPHARMACOLOGY
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