Quantitative phosphoproteomics reveals molecular pathway network alterations in human early-stage primary hepatic carcinomas: potential for 3P medical approach

Protein phosphorylation database and prediction tools

(2023) Ming-Xiao Zhao et al.   BRIEFINGS IN BIOINFORMATICS

p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis

(2023) Carli E. Mager et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination immunotherapy for hepatocellular carcinoma

(2023) Lorenza Rimassa et al.   JOURNAL OF HEPATOLOGY

Design and Synthesis of 3-(β-d-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential

(2023) Sándor Kun et al.   MOLECULES

Gradual deterioration of fatty liver disease to liver cancer via inhibition of AMPK signaling pathways involved in energy-dependent disorders, cellular aging, and chronic inflammation

(2023) Sha-Sha Meng et al.   Frontiers in Oncology

Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis

(2022) Yosuke Inomata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma

(2022) Chuan-Yuan Wei et al.   JOURNAL OF HEPATOLOGY

A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

(2022) Jiao Zhao et al.   MOLECULAR CELL

Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages

(2022) Charlotte K. Y. Ng et al.   Nature Communications

Improving Cancer Immunotherapy: Exploring and Targeting Metabolism in Hypoxia Microenvironment

(2022) Jinfen Wei et al.   Frontiers in Immunology

Comprehensive analysis of spliceosome genes and their mutants across 27 cancer types in 9070 patients: clinically relevant outcomes in the context of 3P medicine

(2022) Zhen Ye et al.   EPMA Journal

Pathological implication of protein post-translational modifications in cancer

(2022) Sheng Pan et al.   MOLECULAR ASPECTS OF MEDICINE

Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma

(2022) Haowen Jiang et al.   CANCER RESEARCH

Identification of a novel histone phosphorylation prognostic signature in hepatocellular carcinoma based on bulk and single-cell RNA sequencing

(2022) Lei Fan et al.   Frontiers in Endocrinology

Liver tumour immune microenvironment subtypes and neutrophil heterogeneity

(2022) Ruidong Xue et al.   NATURE

Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma

(2021) Josep M. Llovet et al.   Nature Reviews Gastroenterology & Hepatology

De novo design of a reversible phosphorylation-dependent switch for membrane targeting

(2021) Leon Harrington et al.   Nature Communications

Advances in immunotherapy for hepatocellular carcinoma

(2021) Bruno Sangro et al.   Nature Reviews Gastroenterology & Hepatology

Second-line treatments for Advanced Hepatocellular Carcinoma: A Systematic Review and Bayesian Network Meta-analysis

(2021) Antonio Giovanni Solimando et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Early glycolytic reprogramming controls microglial inflammatory activation

(2021) Junjie Cheng et al.   Journal of Neuroinflammation

PPM1G promotes the progression of hepatocellular carcinoma via phosphorylation regulation of alternative splicing protein SRSF3

(2021) Dawei Chen et al.   Cell Death & Disease

Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer

(2021) Macus Hao-Ran Bao et al.   Cells

DDX17‐regulated alternative splicing that produced an oncogenic isoform of PXN‐AS1 to promote HCC metastasis

(2021) Hong‐Zhong Zhou et al.   HEPATOLOGY

SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α

(2021) Maoquan Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Dynamic interplay of two molecular switches enabled by the MEK1/2–ERK1/2 and IL-6–STAT3 signaling axes controls epithelial cell migration in response to growth factors

(2021) Lyugao Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunotherapies for hepatocellular carcinoma

(2021) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine

(2021) Xianquan Zhan et al.   EPMA Journal

Integrated genomic analysis of proteasome alterations across 11,057 patients with 33 cancer types: clinically relevant outcomes in framework of 3P medicine

(2021) Na Li et al.   EPMA Journal

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

(2021) Maria Reig et al.   JOURNAL OF HEPATOLOGY

Molecular therapies for HCC: Looking outside the box

(2020) Sandrine Faivre et al.   JOURNAL OF HEPATOLOGY

Diet and liver cancer risk: a narrative review of epidemiological evidence

(2020) Wan-Shui Yang et al.   BRITISH JOURNAL OF NUTRITION

CPBMF65, a synthetic human uridine phosphorylase-1 inhibitor, reduces HepG2 cell proliferation through cell cycle arrest and senescence

(2020) Elisa Feller Gonçalves da Silva et al.   INVESTIGATIONAL NEW DRUGS

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

(2020) Wei Wu et al.   CELL

Phosphoproteomic Analysis across the Yeast Life Cycle Reveals Control of Fatty Acyl Chain Length by Phosphorylation of the Fatty Acid Synthase Complex

(2020) Fernando Martínez-Montañés et al.   Cell Reports

Integration of quantitative phosphoproteomics and transcriptomics revealed phosphorylation-mediated molecular events as useful tools for a potential patient stratification and personalized treatment of human nonfunctional pituitary adenomas

(2020) Dan Liu et al.   EPMA Journal

Hypoxia-inducible factors and innate immunity in liver cancer

(2020) Vincent Wai-Hin Yuen et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine

(2020) Na Li et al.   EPMA Journal

Vaccination contre le virus de l’hépatite B et prévention du cancer du foie

(2020) Fanny Lebossé et al.   BULLETIN DU CANCER

Could ketogenic diet “starve” cancer? Emerging evidence

(2020) Luigi Barrea et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The role of alternative splicing in cancer: From oncogenesis to drug resistance

(2020) Rocco Sciarrillo et al.   DRUG RESISTANCE UPDATES

Sophoridine suppresses lenvatinib‐resistant hepatocellular carcinoma growth by inhibiting RAS/MEK/ERK axis via decreasing VEGFR2 expression

(2020) Zhongwei Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Understanding tumour cell heterogeneity and its implication for immunotherapy in liver cancer using single-cell analysis

(2020) Sophia Heinrich et al.   JOURNAL OF HEPATOLOGY

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

(2019) Ying Jiang et al.   NATURE

ANXA2Tyr23 and FLNASer2152 phosphorylation associate with poor prognosis in hepatic carcinoma revealed by quantitative phosphoproteomics analysis

(2019) Xiaohua Xing et al.   Journal of Proteomics

The Mitochondrion as an Emerging Therapeutic Target in Cancer

(2019) Katherine G. Roth et al.   TRENDS IN MOLECULAR MEDICINE

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

(2019) Yang Eric Guo et al.   NATURE

TMT-based quantitative proteomics revealed follicle-stimulating hormone (FSH)-related molecular characterizations for potentially prognostic assessment and personalized treatment of FSH-positive non-functional pituitary adenomas

(2019) Ya Wang et al.   EPMA Journal

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

Challenges in liver cancer and possible treatment approaches

(2019) David Anwanwan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Enhanced antitumor activity of combined megestrol acetate and arsenic trioxide treatment in liver cancer cells

(2018) Yan Xia et al.   Experimental and Therapeutic Medicine

STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma

(2015) Weiyun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

(2015) Anna Kuchnio et al.   Cell Reports

Recruiting a Silent Partner for Activation of the Protein Kinase SRPK1

(2014) Brandon E. Aubol et al.   BIOCHEMISTRY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma

(2013) L. Zheng et al.   CLINICAL CANCER RESEARCH

Phospho-GSK-3β is involved in the high-glucose-mediated lipid deposition in renal tubular cells in diabetes

(2013) Wei Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Comprehensive Analysis of Phosphorylation Sites in Tensin1 Reveals Regulation by p38MAPK

(2010) Emily H. Hall et al.   MOLECULAR & CELLULAR PROTEOMICS