Targeting Anaerobic Respiration in Pseudomonas aeruginosa with Chlorate Improves Healing of Chronic Wounds

Visualization of mRNA Expression in Pseudomonas aeruginosa Aggregates Reveals Spatial Patterns of Fermentative and Denitrifying Metabolism

(2022) Jadzia Livingston et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Mechanisms of chlorate toxicity and resistance in Pseudomonas aeruginosa

(2022) Melanie A. Spero et al.   MOLECULAR MICROBIOLOGY

Signaling Pathways Associated with Chronic Wound Progression: A Systems Biology Approach

(2022) Proma Basu et al.   Antioxidants

Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in Mycobacterium tuberculosis

(2021) Erik J. Hasenoehrl et al.   Frontiers in Cellular and Infection Microbiology

Using systems biology approaches to identify signalling pathways activated during chronic wound initiation

(2021) Proma Basu et al.   WOUND REPAIR AND REGENERATION

The current burden of diabetic foot disease

(2021) Michael Edmonds et al.   Journal of Clinical Orthopaedics and Trauma

Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds

(2020) Samuel Verbanic et al.   npj Biofilms and Microbiomes

High Levels of Oxidative Stress Create a Microenvironment That Significantly Decreases the Diversity of the Microbiota in Diabetic Chronic Wounds and Promotes Biofilm Formation

(2020) Jane H. Kim et al.   Frontiers in Cellular and Infection Microbiology

Quantitative Visualization of Gene Expression in Mucoid and Nonmucoid Pseudomonas aeruginosa Aggregates Reveals Localized Peak Expression of Alginate in the Hypoxic Zone

(2019) Peter Jorth et al.   mBio

High Levels of Oxidative Stress and Skin Microbiome are Critical for Initiation and Development of Chronic Wounds in Diabetic Mice

(2019) Jane H. Kim et al.   Scientific Reports

The role of the microbiome in nonhealing diabetic wounds

(2018) Lindsay R. Kalan et al.   Annals of the New York Academy of Sciences

Pseudomonas aeruginosatranscriptome during human infection

(2018) Daniel M. Cornforth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chlorate Specifically Targets Oxidant-Starved, Antibiotic-Tolerant Populations of Pseudomonas aeruginosa Biofilms

(2018) Melanie A. Spero et al.   mBio

Temporal Stability in Chronic Wound Microbiota Is Associated With Poor Healing

(2017) Michael Loesche et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Understanding and Sensitizing Density-Dependent Persistence to Quinolone Antibiotics

(2017) Arnaud Gutierrez et al.   MOLECULAR CELL

Identification of Fitness Determinants during Energy-Limited Growth Arrest in Pseudomonas aeruginosa

(2017) David W. Basta et al.   mBio

A longitudinal study of the diabetic skin and wound microbiome

(2017) Melissa Gardiner et al.   PeerJ

Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing – A feasibility study

(2017) Lindsay Kalan et al.   PLoS One

(Per)chlorate in Biology on Earth and Beyond

(2016) Matthew D. Youngblut et al.   Annual Review of Microbiology

One step closer to understanding the role of bacteria in diabetic foot ulcers: characterising the microbiome of ulcers

(2016) Karen Smith et al.   BMC MICROBIOLOGY

Microsensor and transcriptomic signatures of oxygen depletion in biofilms associated with chronic wounds

(2016) Garth A. James et al.   WOUND REPAIR AND REGENERATION

Exposing the Three-Dimensional Biogeography and Metabolic States of Pathogens in Cystic Fibrosis Sputum via Hydrogel Embedding, Clearing, and rRNA Labeling

(2016) William H. DePas et al.   mBio

Microbiology of diabetic foot infections: from Louis Pasteur to ‘crime scene investigation’

(2015) Anne Spichler et al.   BMC Medicine

Biofilm-specific antibiotic tolerance and resistance

(2015) I. Olsen   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Pediatric Cystic Fibrosis Sputum Can Be Chemically Dynamic, Anoxic, and Extremely Reduced Due to Hydrogen Sulfide Formation

(2015) Elise S. Cowley et al.   mBio

Next-Generation in Situ Hybridization Chain Reaction: Higher Gain, Lower Cost, Greater Durability

(2014) Harry M. T. Choi et al.   ACS Nano

Polymorphonuclear Leukocytes Restrict Growth of Pseudomonas aeruginosa in the Lungs of Cystic Fibrosis Patients

(2014) Kasper N. Kragh et al.   INFECTION AND IMMUNITY

Antibiotic resistance in Pseudomonas aeruginosa biofilms: Towards the development of novel anti-biofilm therapies

(2014) Patrick K. Taylor et al.   JOURNAL OF BIOTECHNOLOGY

Nitrous Oxide Production in Sputum from Cystic Fibrosis Patients with Chronic Pseudomonas aeruginosa Lung Infection

(2014) Mette Kolpen et al.   PLoS One

Biogeochemical Forces Shape the Composition and Physiology of Polymicrobial Communities in the Cystic Fibrosis Lung

(2014) R. A. Quinn et al.   mBio

Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

(2014) Laura Line et al.   Frontiers in Microbiology

Generating and Reversing Chronic Wounds in Diabetic Mice by Manipulating Wound Redox Parameters

(2014) Sandeep Dhall et al.   Journal of Diabetes Research

Regular debridement is the main tool for maintaining a healthy wound bed in most chronic wounds

(2014) R.D. Wolcott et al.   Journal of Wound Care

Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut

(2013) S. E. Winter et al.   SCIENCE

Nitric oxide levels in wound fluid may reflect the healing trajectory

(2013) Stéphanie F. Bernatchez et al.   WOUND REPAIR AND REGENERATION

Efficacy and safety of IV/PO moxifloxacin and IV piperacillin/tazobactam followed by PO amoxicillin/clavulanic acid in the treatment of diabetic foot infections: results of the RELIEF study

(2012) N. C. Schaper et al.   INFECTION

INVITED REVIEW: Efficacy, metabolism, and toxic responses to chlorate salts in food and laboratory animals1

(2012) D. J. Smith et al.   JOURNAL OF ANIMAL SCIENCE

Deletion of a tumor necrosis superfamily gene in mice leads to impaired healing that mimics chronic wounds in humans

(2012) Melissa L. Petreaca et al.   WOUND REPAIR AND REGENERATION

Adaptation and Antibiotic Tolerance of Anaerobic Burkholderia pseudomallei

(2011) Mohamad A. Hamad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Susceptibility of Pseudomonas aeruginosa Urinary Tract Isolates and Influence of Urinary Tract Conditions on Antibiotic Tolerance

(2011) Maike Narten et al.   CURRENT MICROBIOLOGY

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

(2011) Lei Chen et al.   Nature Reviews Endocrinology