A novel deep generative model for mRNA vaccine development: Designing 5ʹ UTRs with N1-methyl-pseudouridine modification

Trial settles debate over best design for mRNA in COVID vaccines

(2023) Elie Dolgin   NATURE

Liver injury after SARS‐CoV ‐2 vaccination: Features of immune‐mediated hepatitis, role of corticosteroid therapy and outcome

(2022) Cumali Efe et al.   HEPATOLOGY

The clinical progress of mRNA vaccines and immunotherapies

(2022) Ann J. Barbier et al.   NATURE BIOTECHNOLOGY

Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants

(2022) Na Fan et al.   Science Advances

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

(2021) Annette B. Vogel et al.   NATURE

Determinants of genome-wide distribution and evolution of uORFs in eukaryotes

(2021) Hong Zhang et al.   Nature Communications

Vaccine development for emerging infectious diseases

(2021) Jean-Louis Excler et al.   NATURE MEDICINE

Myocarditis With COVID-19 mRNA Vaccines

(2021) Biykem Bozkurt et al.   CIRCULATION

Accelerated COVID-19 vaccine development: milestones, lessons, and prospects

(2021) Karin Bok et al.   IMMUNITY

Liver injury following SARS-CoV-2 vaccination: a multicenter case series

(2021) Hersh Shroff et al.   JOURNAL OF HEPATOLOGY

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

A guide to machine learning for biologists

(2021) Joe G. Greener et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies

(2021) Jicong Cao et al.   Nature Communications

Membrane-dependent relief of translation elongation arrest on pseudouridine- and N1-methyl-pseudouridine-modified mRNAs

(2021) Yuri V Svitkin et al.   NUCLEIC ACIDS RESEARCH

Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation

(2020) Hanhan Shi et al.   Molecular Cancer

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo

(2020) Chunxi Zeng et al.   ADVANCED MATERIALS

Human 5′ UTR design and variant effect prediction from a massively parallel translation assay

(2019) Paul J. Sample et al.   NATURE BIOTECHNOLOGY

Conservation and Variability of the AUG Initiation Codon Context in Eukaryotes

(2019) Greco Hernández et al.   TRENDS IN BIOCHEMICAL SCIENCES

Convolutional neural networks for classification of alignments of non-coding RNA sequences

(2018) Genta Aoki et al.   BIOINFORMATICS

Opportunities and obstacles for deep learning in biology and medicine

(2018) Travers Ching et al.   Journal of the Royal Society Interface

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Heterogeneity and specialized functions of translation machinery: from genes to organisms

(2018) Naomi R. Genuth et al.   NATURE REVIEWS GENETICS

Maximizing the translational yield of mRNA therapeutics by minimizing 5'-UTRs

(2018) Zeljka Trepotec et al.   TISSUE ENGINEERING PART A

Deep learning of the regulatory grammar of yeast 5′ untranslated regions from 500,000 random sequences

(2017) Josh T. Cuperus et al.   GENOME RESEARCH

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

(2017) Kathrin Leppek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

(2017) Yuri V. Svitkin et al.   NUCLEIC ACIDS RESEARCH

Translational control by 5'-untranslated regions of eukaryotic mRNAs

(2016) A. G. Hinnebusch et al.   SCIENCE

Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts

(2016) Mehrije Ferizi et al.   Scientific Reports

Cellular Differences in Protein Synthesis Regulate Tissue Homeostasis

(2014) Michael Buszczak et al.   CELL

The Vienna RNA Websuite

(2008) A. R. Gruber et al.   NUCLEIC ACIDS RESEARCH