Article
Immunology
Xueli Yang, Tian Chang, Qian Yuan, Wei Wei, Pingping Wang, Xiaojian Song, Huijuan Yuan
Summary: This study investigates the variations in gut microbiota (GM) and vaginal microbiota (VM) in postmenopausal women with osteoporosis. The results show that changes in bone mineral density are associated with changes in GM and VM, with GM being more closely correlated with postmenopausal osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Shuai Chen, Guowei Zhou, Huawei Han, Jie Jin, Zhiwei Li
Summary: Recent research has found a causal relationship between gut microbiota and bone mineral density (BMD), with specific bacterial taxa regulating bone mass variation. This study used Mendelian randomization analysis to investigate this relationship further and identified several gut microbiota taxa associated with BMD. These findings offer new insights into potential microbiota-related mechanisms of bone metabolism and may contribute to the prevention and treatment of osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhiyuan Guan, Zheng Xuanqi, Junxiong Zhu, Wanqiong Yuan, Jialin Jia, Chenggui Zhang, Tiantong Sun, Huijie Leng, Changtao Jiang, Yingsheng Xu, Chunli Song
Summary: Postmenopausal osteoporosis is a common bone metabolic disease, and gut microbiota (GM) imbalance plays an important role in its development. This study found that ovariectomized mice had gut microbiota dysbiosis, and reducing gut microbiota through antibiotic treatment improved bone health. G-protein coupled bile acid receptor and systemic inflammatory factors were identified as key players in bone metabolism.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Applied
Qingshan Shen, Chunhui Zhang, Xiaojie Qin, Hongru Zhang, Zhiqiang Zhang, Aurore Richel
Summary: The study showed that the dietary intervention of chondroitin sulfate calcium complex (CSCa) could improve bone mineral density and microstructure in osteoporosis rats, as well as alter the composition of gut microbiota and metabolite profiles. This suggests that CSCa may have the potential to alleviate osteoporosis and related symptoms through the modulation of gut microbiota and metabolites.
CARBOHYDRATE POLYMERS
(2021)
Article
Endocrinology & Metabolism
Jing-Jing Ni, Xiao-Lin Yang, Hong Zhang, Qian Xu, Xin-Tong Wei, Gui-Juan Feng, Min Zhao, Yu-Fang Pei, Lei Zhang
Summary: Recent study used Mendelian randomization to assess the impact of gut microbiota on bone development. Specific bacterial taxa, including Clostridiales and Lachnospiraceae, were found to be associated with bone mass variation, providing new insights into the microbiota mediated bone development mechanism.
Review
Microbiology
Yu Chen, Xin Wang, Chunlei Zhang, Zhiyong Liu, Chao Li, Zhigang Ren
Summary: Gut microbiota plays a crucial role in human health and disease, and dysbiosis in the gut microbiota has been linked to various bone diseases. Recent studies have contributed to our understanding of the relationship between gut microbiota and bone disorders, and offer potential preventive and therapeutic approaches for these conditions.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Dageng Huang, Jihan Wang, Yuhong Zeng, Qingmei Li, Yangyang Wang
Summary: The aim of this study was to characterize the gut microbiota signatures in postmenopausal osteoporosis (PMOP) patients and controls. Results showed that the composition of gut microbiota changed in PMOP patients, and microbial abundances were more correlated with total hip bone mineral density (BMD)/T-score than lumbar spine BMD/T-score. Using feature selection algorithms, a set of PMOP-related microbes were identified, and logistic regression analysis revealed that Fusobacteria and Lactobacillaceae had significant abilities in disease classification between the PMOP and control groups.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Qihui Yan, Liping Cai, Weiying Guo
Summary: The gut microbiota plays a significant role in the pathogenesis of diseases and is closely associated with bone metabolism. It affects bone health by modulating nutrient absorption, intestinal permeability, metabolites, immune responses, and hormones or neurotransmitters. External interventions like dietary changes can improve bone health and alter the composition of the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lingyun Lu, Xiaoxuan Chen, Yi Liu, Xijie Yu
Summary: Osteoporosis is closely related to gut microbiota, influencing bone metabolism balance. Perturbation of GM can disrupt bone remodeling balance, while GM metabolites may regulate bone turnover, providing new perspectives for the prevention and treatment of osteoporosis.
Review
Cell Biology
Alessandro de Sire, Roberto de Sire, Claudio Curci, Fabiana Castiglione, Walter Wahli
Summary: Osteoporosis is a major global health burden, and changes in intestinal homeostasis are being investigated as a potential therapeutic target. Disruptions in the intestinal microbiota are associated with reduced bone strength and quality, and dietary supplements and probiotics may play a role in regulating bone health and osteoporosis through modulation of the gut microbiota.
Review
Medicine, Research & Experimental
Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Xiang-Xu Chen, Qian Yu, Yun-Feng Rui
Summary: Osteoporosis is a bone disease that can result in bone fragility and fractures. Exercise is an effective intervention for preventing and treating osteoporosis and has been found to have an impact on gut microbiota and bone metabolism. This review discusses the effects and mechanisms of exercise intervention on gut microbiota and bone metabolism.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kevin D. Seely, Cody A. Kotelko, Hannah Douglas, Brandon Bealer, Amanda E. Brooks
Summary: The gut microbiota has been shown to play a role in bone metabolism and the pathogenesis of osteoporosis. Despite the established connection between a healthy microbiome and bone homeostasis, the specific mechanisms underlying this relationship are not fully understood. Studying the interactions between the microbiome, osteoblasts, osteoclasts, and RANKL may offer insights into potential therapeutic targets for promoting bone health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
J. Li, W. T. P. Ho, C. Liu, S. K-H Chow, M. Ip, J. Yu, H. S. Wong, W-H Cheung, J. J. Y. Sung, R. M. Y. Wong
Summary: This systematic review analyzed the impact of gut microbiota on bone health, finding that probiotics, prebiotics, nutritional interventions, and traditional Chinese medicine can reverse gut microbiota dysbiosis and rescue bone loss.
BONE & JOINT RESEARCH
(2021)
Article
Neurosciences
Xiayun Wan, Akifumi Eguchi, Yuko Fujita, Li Ma, Xingming Wang, Yong Yang, Youge Qu, Lijia Chang, Jiancheng Zhang, Chisato Mori, Kenji Hashimoto
Summary: Depression is associated with low bone mineral density (BMD) and a novel antidepressant (R)-ketamine can improve reduced BMD. This study found that gut microbiota plays a role in the beneficial effects of (R)-ketamine on reducing BMD. Therefore, (R)-ketamine could be a therapeutic drug for depressed patients or patients with osteoporosis.
Article
Immunology
Yangyang Wang, Xiaoguang Gao, Jing Lv, Yuhong Zeng, Qingmei Li, Liping Wang, Yuanyuan Zhang, Wenjie Gao, Jihan Wang
Summary: This study clarifies the composition and gene functional profile of the gut microbiome (GM) in older individuals with normal and low bone mineral density (BMD). It provides evidence regarding the mechanisms by which GM affects bone health and identifies potential diagnostic and therapeutic targets for osteoporosis (OP) and postmenopausal osteoporosis (PMOP). Furthermore, it highlights the importance of addressing and improving vitamin D deficiency or insufficiency in the Chinese population.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rajesh Venkataraman, Ratna Sudha Madempudi, Jayanthi Neelamraju, Jayesh J. Ahire, H. R. Vinay, Anila Lal, Glory Thomas, Stephy Stephen
Summary: This study indicates that multi-strain probiotics can effectively reduce stress levels, depression and anxiety, and serum cortisol levels in students facing examination stress, with no reported adverse events during the study period.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Biotechnology & Applied Microbiology
V. R. Yenuganti, R. Yadala, R. Azad, S. Singh, V. Chiluka, J. Ahire, P. Reddanna
Summary: The study identified 11 probiotic strains with anticancer effects on human colorectal carcinoma cells, affecting gene expression, some of which induced apoptosis and could be potential candidates for CRC treatment.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
J. J. Ahire, M. S. Kashikar, R. S. Madempudi
Summary: The study demonstrated that B. clausii UBBC07 spores exhibit higher survival and adhesion in vitro gastrointestinal conditions compared to vegetative cells, attributed to their stability and hydrophobicity. In addition, the identification of genome features suggested their contribution to probiotic properties.
Article
Biotechnology & Applied Microbiology
J. J. Ahire, S. Sahoo, M. S. Kashikar, A Heerekar, S. G. Lakshmi, R. S. Madempudi
Summary: In this study, lactobacillus strains isolated from healthy reproductive age Indian women were screened for beneficial probiotic properties. The strains showed survival capabilities under various conditions, inhibited the growth of pathogens, and could adhere and co-aggregate with them. They also secreted exopolysaccharides and formed biofilms. Safety assessment indicated their potential for human trials to prevent/treat vaginal dysbiosis.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biotechnology & Applied Microbiology
R. Venkataraman, R. Shenoy, J. J. Ahire, J. Neelamraju, R. S. Madempudi
Summary: This study evaluated the efficacy of combining Bacillus coagulans Unique IS2 and lactulose in treating functional constipation in adults. The results showed that the combination of B.coagulans Unique IS2 and lactulose was more effective than lactulose alone in relieving constipation symptoms in a shorter period of time.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Nutrition & Dietetics
Ishwarpreet Kaur, Vanita Suri, Naresh Sachdeva, Satya Vati Rana, Bikas Medhi, Nancy Sahni, Jayesh Ahire, Amarjeet Singh
Summary: The use of multi-strain probiotic along with dietary and lifestyle modifications has been found to be effective in managing PCOS, with positive effects on menstrual regularity, weight reduction, metabolic and hormonal profile.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Food Science & Technology
J. J. Ahire, N. U. Mokashe, M. S. Kashikar, R. S. Madempudi
Summary: This study investigated the survival of Limosilactobacillus reuteri UBLRu-87 in an in vitro gut model system. The results showed that without glucose, the strain lost its ability to grow and multiply in the intestines, but remained viable in a non-culturable state. In the presence of glucose, the strain was able to protect itself and enhance its viability during passage through the gastrointestinal tract.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Microbiology
R. S. Madempudi, J. Neelamraju, J. J. Ahire, M. Muthukumar, S. Rudrappa, G. Gopal, K. Nagendra
Summary: Probiotic Bacillus clausii UBBC-07 has a significant effect on symptom management of upper respiratory tract infections (URTIs) in children, reducing the number, duration, and severity of URTIs, and promoting immune homeostasis.
BENEFICIAL MICROBES
(2022)
Review
Biotechnology & Applied Microbiology
Vikram, Vijendra Mishra, Ananya Rana, Jayesh J. Ahire
Summary: Riboswitches are used by prokaryotic organisms to quantify intracellular metabolite concentration. They control gene expression by binding with specific metabolites and modulating various biochemical pathways. This article focuses on how riboswitch regulates the riboflavin biosynthesis pathway in Bacillus subtilis and Lactobacillus plantarum.
Article
Biotechnology & Applied Microbiology
Dina B. Saroj, Jayesh J. Ahire, Rohit Shukla
Summary: In this study, the authors analyzed the whole genome sequence of the probiotic Bacillus clausii 088AE and identified its genome features that contribute to its probiotic properties. The genome sequence had a single scaffold of 4,598,457 bp with 44.74 mol% G + C and was annotated to have 4371 coding genes, 75 tRNAs, and 22 rRNAs. Taxonomic analysis revealed its high similarity (99%) to B. clausii DSM 8716. The presence of genome features related to safety, genome stability, and probiotic characteristics confirmed the strain to be safe for use as a probiotic.
Review
Biotechnology & Applied Microbiology
Yogini Dixit, Khushboo Kanojiya, Namrata Bhingardeve, Jayesh J. Ahire, Dina Saroj
Summary: Simulated human gastrointestinal (GI) tract systems play important roles in the fields of probiotics, nutrition, and health. In vitro gut models have advantages over in vivo investigations, despite the challenges of mimicking the GI environment. This review provides a comprehensive overview of the development of in vitro GI models, highlighting their limitations and potential for improvement.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Microbiology
Yogini Dixit, Khushboo Kanojiya, Namrata Bhingardeve, Jayesh J. Ahire, Dina Saroj
Summary: In this study, the production, characterization, and identification of antimicrobial compounds from Alkalihalobacillus clausii 088AE were evaluated. The results demonstrated that the supernatant of 48-h-old A. clausii can inhibit the growth of Micrococcus luteus (7.0 & PLUSMN; 0.51 mm). Enhanced antimicrobial activity (19.67 & PLUSMN; 0.58 mm) against indicator strain was observed after cultivating 088AE on solid media with XAD16N beads for 5 days and extracting the antimicrobial compound with isopropanol. The purified compound, clausin, showed stability in various conditions and antimicrobial activity against Gram-positive pathogens.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Food Science & Technology
Vikram Kumar, Vinkel Kumar Arora, Ananya Rana, Ankur Kumar, Neetu Kumra Taneja, Jayesh J. Ahire
Summary: This study investigated the overproduction of riboflavin in selected Lactiplantibacillus plantarum strain and achieved a 24% increase in riboflavin production by optimizing the conditions using a fuzzy inference system.
Article
Microbiology
Vikram Kumar, Neetu Kumra Taneja, Shakti Kumar, Atul Vashist, Jayesh J. Ahire, Vijendra Mishra
Summary: We report the complete genome sequence of Lactiplantibacillus plantarum BBC32B, which was isolated from a human feces sample and shares 69.67% average nucleotide identity with the closest species of Lactobacillus brevis ATCC367.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)