Structural and functional studies of a trans -acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction

Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry

(2013) Jianting Zheng et al.   ACS Chemical Biology

Structure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide Synthase

(2013) Darren Gay et al.   BIOCHEMISTRY

Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

(2013) Shilah A. Bonnett et al.   CHEMISTRY & BIOLOGY

Substrate-Dependent Stereospecificity of Tyl-KR1: An Isolated Polyketide Synthase Ketoreductase Domain fromStreptomyces fradiae

(2013) Matthias Häckh et al.   CHEMISTRY-A EUROPEAN JOURNAL

Vinylogous chain branching catalysed by a dedicated polyketide synthase module

(2013) Tom Bretschneider et al.   NATURE

Assembly and Absolute Configuration of Short-Lived Polyketides fromBurkholderia thailandensis

(2012) Keishi Ishida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal structure of hexanoyl-CoA bound to β-ketoacyl reductase FabG4 ofMycobacterium tuberculosis

(2012) Debajyoti Dutta et al.   BIOCHEMICAL JOURNAL

Biosynthesis of the Respiratory Toxin Bongkrekic Acid in the Pathogenic Bacterium Burkholderia gladioli

(2012) Nadine Moebius et al.   CHEMISTRY & BIOLOGY

The structures of type I polyketide synthases

(2012) Adrian T. Keatinge-Clay   NATURAL PRODUCT REPORTS

A fungal ketoreductase domain that displays substrate-dependent stereospecificity

(2012) Hui Zhou et al.   Nature Chemical Biology

The status of type I polyketide synthase ketoreductases

(2012) Jianting Zheng et al.   MedChemComm

Structure and Mechanism of thetrans-Acting Acyltransferase from the Disorazole Synthase

(2011) Fong T. Wong et al.   BIOCHEMISTRY

Employing Modular Polyketide Synthase Ketoreductases as Biocatalysts in the Preparative Chemoenzymatic Syntheses of Diketide Chiral Building Blocks

(2011) Shawn K. Piasecki et al.   CHEMISTRY & BIOLOGY

Mechanism and Stereospecificity of a Fully Saturating Polyketide Synthase Module: Nanchangmycin Synthase Module 2 and Its Dehydratase Domain

(2010) Xun Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereospecificity of the Dehydratase Domain of the Erythromycin Polyketide Synthase

(2010) Chiara R. Valenzano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

(2010) David L. Akey et al.   STRUCTURE

Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase

(2010) Jianting Zheng et al.   STRUCTURE

Stereochemical Determination of Thuggacins A–C, Highly Active Antibiotics from the MyxobacteriumSorangium cellulosum

(2008) Martin Bock et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

(2008) Adrian Keatinge-Clay   JOURNAL OF MOLECULAR BIOLOGY

Stereochemical Determination and Complex Biosynthetic Assembly of Etnangien, a Highly Potent RNA Polymerase Inhibitor from the Myxobacterium Sorangium cellulosum

(2008) Dirk Menche et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

(2008) Elizabeth S. Sattely et al.   NATURAL PRODUCT REPORTS

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY

A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both  - and  -ketone reduction during chain growth

(2008) C. T. Calderone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA