Disease-modifying agents in osteoarthritis: where are we now and what does the future hold?

Decreased Peli1 expression attenuates osteoarthritis by protecting chondrocytes and inhibiting M1-polarization of macrophages

(2023) Haokun Mo et al.   Bone & Joint Research

Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways

(2023) Rui Lu et al.   Bone & Joint Research

Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis

(2022) Yuqing Wang et al.   BMC MUSCULOSKELETAL DISORDERS

Shared genetic liability between major depressive disorder and osteoarthritis

(2022) Fuquan Zhang et al.   Bone & Joint Research

CircSCAPER contributes to IL-1β-induced osteoarthritis in vitro via miR-140-3p/EZH2 axis

(2022) Zhaxi Luobu et al.   Bone & Joint Research

Prevalence Trends of Site‐Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019

(2022) Huibin Long et al.   Arthritis & Rheumatology

Exercise modifies the disease-relevant gut microbial shifts in post-traumatic osteoarthritis rats

(2022) Xiaoxia Hao et al.   Bone & Joint Research

Long noncoding RNA H19 alleviates inflammation in osteoarthritis through interactions between TP53, IL-38, and IL-36 receptor

(2022) Yeli Zhou et al.   Bone & Joint Research

Simultaneous bilateral total knee arthroplasty is associated with shorter length of stay but increased mortality compared with staged bilateral total knee arthroplasty: a systematic review and meta-analysis

(2021) Navnit S. Makaram et al.   JOURNAL OF ARTHROPLASTY

Intra-articular low-dose parathyroid hormone (1-34) improves mobility and articular cartilage quality in a preclinical age-related knee osteoarthritis model

(2021) Chung-Hwan Chen et al.   Bone & Joint Research

Molecular Classification of Knee Osteoarthritis

(2021) Zhongyang Lv et al.   Frontiers in Cell and Developmental Biology

Osteoarthritis year in review 2021: epidemiology & therapy

(2021) J.G. Quicke et al.   OSTEOARTHRITIS AND CARTILAGE

Expression profile of matrix metalloproteinases in the labrum of femoroacetabular impingement

(2020) Jason Schon et al.   Bone & Joint Research

Fibroblast growth factor signalling in osteoarthritis and cartilage repair

(2020) Yangli Xie et al.   Nature Reviews Rheumatology

Parathyroid hormone (1-34) ameliorates cartilage degeneration and subchondral bone deterioration in collagenase-induced osteoarthritis model in mice

(2020) Li-tao Shao et al.   Bone & Joint Research

Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice

(2020) Zhiyuan Guan et al.   CLINICAL SCIENCE

Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway

(2019) Mariana M. Oliveira et al.   Oxidative Medicine and Cellular Longevity

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

(2019) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee

(2018) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

Sprifermin treatment enhances cartilage integration in an in vitro repair model

(2018) Mackenzie L. Sennett et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Obesity, osteoarthritis and genetic risk

(2018) L. Jiang et al.   Bone & Joint Research

Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics

(2018) Win Min Oo et al.   EXPERT OPINION ON EMERGING DRUGS

The effect of probiotic Lactobacillus casei Shirota on knee osteoarthritis: a randomised double-blind, placebo-controlled clinical trial

(2017) M. Lei et al.   Beneficial Microbes

The gut microbiome in health and in disease

(2015) Andrew B. Shreiner et al.   CURRENT OPINION IN GASTROENTEROLOGY

Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis

(2015) K. Hamamura et al.   Bone & Joint Research

The individual and socioeconomic impact of osteoarthritis

(2014) David J. Hunter et al.   Nature Reviews Rheumatology

Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis

(2014) J.-y. Yan et al.   OSTEOARTHRITIS AND CARTILAGE

Defining and mapping the person with osteoarthritis for population studies and public health

(2013) E. Thomas et al.   RHEUMATOLOGY

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Clinical significance of bone changes in osteoarthritis

(2012) Tuhina Neogi   Therapeutic Advances in Musculoskeletal Disease

Subchondral bone as a key target for osteoarthritis treatment

(2011) Santos Castañeda et al.   BIOCHEMICAL PHARMACOLOGY

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

BMP-7 inhibits cartilage degeneration through suppression of inflammation in rat zymosan-induced arthritis

(2011) Toru Takahashi et al.   CELL AND TISSUE RESEARCH

Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes

(2011) Dongyao Yan et al.   ARTHRITIS RESEARCH & THERAPY

Anticytokine Therapy for Osteoarthritis

(2010) Charles J. Malemud   DRUGS & AGING

The Role of Bone in Osteoarthritis Pathogenesis

(2008) Steven R. Goldring   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA