Transcriptional characteristics and functional validation of three monocyte subsets during aging

The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis

(2022) Yuan Yuan et al.   Cellular & Molecular Immunology

Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis

(2022) Kevin C. Stein et al.   NATURE

Cellular senescence

(2022) Marta Varela-Eirín et al.   CURRENT BIOLOGY

Ribosome-associated quality-control mechanisms from bacteria to humans

(2022) Sebastian Filbeck et al.   MOLECULAR CELL

Phenotypic and functional alterations of monocyte subsets with aging

(2022) Yu Cao et al.   Immunity & Ageing

Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism

(2021) Gil Myoung Kang et al.   Cell Metabolism

CD4+ T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria

(2021) Luís Almeida et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

(2021) Laurienne Edgar et al.   CIRCULATION

IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway

(2021) Felipe Valença-Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

(2021) Aurelia Santoro et al.   AGEING RESEARCH REVIEWS

Interleukin 6 reduces vascular smooth muscle cell apoptosis via Prep1 and is associated with aging

(2021) Ilaria Cimmino et al.   FASEB JOURNAL

Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

(2020) Kelsey J. Yamada et al.   PLoS Pathogens

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes

(2020) Massimiliano Bonafè et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

(2020) Felix Renaudin et al.   ANNALS OF THE RHEUMATIC DISEASES

Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated Quality Control

(2020) Cole S. Sitron et al.   Annual Review of Biochemistry

Multifaceted deregulation of gene expression and protein synthesis with age

(2020) Aleksandra S. Anisimova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interplay between immunosenescence and age-related diseases

(2020) Florencia Barbé-Tuana et al.   Seminars in Immunopathology

Immunometabolic control of trained immunity

(2020) Niels P. Riksen et al.   MOLECULAR ASPECTS OF MEDICINE

Translational control in aging and neurodegeneration

(2020) Geena Skariah et al.   Wiley Interdisciplinary Reviews-RNA

The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

(2020) Ivana Bjedov et al.   Genes

Translation elongation rate varies among organs and decreases with age

(2020) Maxim V Gerashchenko et al.   NUCLEIC ACIDS RESEARCH

The Myeloid Cell Compartment—Cell by Cell

(2019) Kevin Bassler et al.   Annual Review of Immunology

Nonclassical Monocytes in Health and Disease

(2019) Prakash Babu Narasimhan et al.   Annual Review of Immunology

Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases

(2019) Theodore S. Kapellos et al.   Frontiers in Immunology

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

(2019) Shan-Ting Liao et al.   Nature Communications

Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

(2019) Daniel J. Tyrrell et al.   CIRCULATION RESEARCH

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

(2018) Michelle R. Marasco et al.   DIABETES

Aging impairs mitochondrial respiratory capacity in classical monocytes

(2018) Brandt D. Pence et al.   EXPERIMENTAL GERONTOLOGY

The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence

(2018) Siew-Min Ong et al.   Cell Death & Disease

Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics

(2018) Justyna Janikiewicz et al.   Cell Death & Disease

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry

(2018) Anouk A.J. Hamers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The regulation of skeletal muscle fatigability and mitochondrial function by chronically elevated interleukin-6

(2018) Brandon N. VanderVeen et al.   EXPERIMENTAL PHYSIOLOGY

Developmental and Functional Heterogeneity of Monocytes

(2018) Martin Guilliams et al.   IMMUNITY

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

(2017) Amit A. Patel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists

(2017) Talibah U. Metcalf et al.   JOURNAL OF IMMUNOLOGY

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

(2016) P. S. Pillai et al.   SCIENCE

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

(2016) Shai S. Shen-Orr et al.   Cell Systems

Drivers of age-related inflammation and strategies for healthspan extension

(2015) Emily L. Goldberg et al.   IMMUNOLOGICAL REVIEWS

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly

(2011) Feng Qian et al.   AGING CELL

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

Monocyte trafficking in acute and chronic inflammation

(2011) Molly A. Ingersoll et al.   TRENDS IN IMMUNOLOGY

Impaired Functions of Peripheral Blood Monocyte Subpopulations in Aged Humans

(2010) Joseph Nyugen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses

(2008) Frederic Geissmann et al.   IMMUNOLOGY AND CELL BIOLOGY