New Wine in an Old Bottle: tPA for Ischemic Stroke Management

Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke

(2020) Georgios Tsivgoulis et al.   Journal of Stroke

FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury

(2020) Ying Cai et al.   Redox Biology

tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?

(2019) Jong S. Kim   Journal of Stroke

The Plasminogen Activation System Promotes Neurorepair in the Ischemic Brain

(2018) Manuel Yepes   CURRENT DRUG TARGETS

Bridging-therapy with intravenous recombinant tissue plasminogen activator improves functional outcome in patients with endovascular treatment in acute stroke

(2017) Ilko L. Maier et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Tissue-type plasminogen activator is a homeostatic regulator of synaptic function in the central nervous system

(2017) Manuel Yepes et al.   Neural Regeneration Research

The serum protein levels of the tPA–BDNF pathway are implicated in depression and antidepressant treatment

(2017) H Jiang et al.   Translational Psychiatry

Tissue-type Plasminogen Activator (tPA) Modulates the Postsynaptic Response of Cerebral Cortical Neurons to the Presynaptic Release of Glutamate

(2016) Valerie Jeanneret et al.   Frontiers in Molecular Neuroscience

Tissue plasminogen activator (tPA) attenuates propofol-induced apoptosis in developing hippocampal neurons

(2016) Chao Liang et al.   SpringerPlus

Impacts of tissue-type plasminogen activator (tPA) on neuronal survival

(2015) Arnaud Chevilley et al.   Frontiers in Cellular Neuroscience

Tissue-type plasminogen activator is a neuroprotectant in the central nervous system

(2015) Manuel Yepes   Frontiers in Cellular Neuroscience

Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain

(2014) K. Hultman et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Tissue-Type Plasminogen Activator Mediates Neuronal Detection and Adaptation to Metabolic Stress

(2013) Fang Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

tPA Regulates Neurite Outgrowth by Phosphorylation of LRP5/6 in Neural Progenitor Cells

(2013) Sung Hoon Lee et al.   MOLECULAR NEUROBIOLOGY

Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2–CREB–ATF3 signaling pathway

(2012) Fang Wu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Tissue plasminogen activator prevents white matter damage following stroke

(2011) Fernando Correa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Subacute intranasal administration of tissue plasminogen activator increases functional recovery and axonal remodeling after stroke in rats

(2011) Zhongwu Liu et al.   NEUROBIOLOGY OF DISEASE

A revised model for the secretion of tPA and cytokines from cultured endothelial cells

(2010) L. Knipe et al.   BLOOD

Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus

(2010) Ramiro Echeverry et al.   JOURNAL OF CLINICAL INVESTIGATION

Reperfusion Therapy for Acute Stroke Improves Outcome by Decreasing Neuroinflammation

(2010) Joan Montaner et al.   Translational Stroke Research