Article
Multidisciplinary Sciences
Yanlin Lv, Feng Li, Shuang Wang, Guihong Lu, Weier Bao, Yugang Wang, Zhiyuan Tian, Wei Wei, Guanghui Ma
Summary: The anticancer platelet-based biomimetic formulation developed in this study integrates photothermal nanoparticles and immunostimulator into platelets to target tumor cells effectively. By accumulating at tumor sites and releasing active components, this formulation induces a strong immune response against residual, metastatic, and recurrent tumors, showing exceptionally high therapeutic efficacy across various murine models.
Article
Nanoscience & Nanotechnology
Danjun Wu, Shumin Xu, Xueling Zhang, Yi Li, Wangyang Zhang, Qinying Yan, Qingliang Yang, Fangyuan Guo, Gensheng Yang
Summary: The study presented a size-tunable nanomicelle system that could effectively penetrate into tumors by triggering the near-infrared laser, achieving superior cancer treatment efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Applied
Wen Zhou, Mingzhi Du, Jinghui Wang, Xuheng Zhang, Tingting Liang, Chen Xie, Quli Fan
Summary: Photothermal therapy (PTT) has shown outstanding efficacy in cancer treatment, but the overexpression of heat shock proteins (HSPs) within tumor cells can reduce the damage caused by high temperature, thereby limiting the therapeutic efficacy. To improve the efficacy, researchers are exploring the combination of PTT with other therapeutic modalities such as chemotherapy and immunotherapy. Recently, the oxygen-independent thermodynamic therapy (TDT) has shown great promise in combination with PTT, as it can enhance the efficacy without inducing additional side effects.
Article
Polymer Science
Qi Wang, Xuefeng Yan, Ping Liu, Yiyan Xu, Qingbao Guan, Zhengwei You
Summary: A new near-infrared light-triggered shape memory polymer (PDA/EA) is developed by combining photothermal conversion agent polydopamine (PDA) nanoparticles and epoxy acrylate polymer (EA) effectively. The introduction of PDA improves the dynamic mechanical properties and thermal resistance compared to EA, making PDA/EA a promising environmentally friendly and highly efficient photoactive SMP.
Article
Engineering, Biomedical
Yang Wu, Guiyun Deng, Kai Jiang, Huajuan Wang, Zhiyong Song, Heyou Han
Summary: An intelligent NO nanogenerator triggered by NIR light was constructed for targeted treatment of P. aeruginosa bacterial infection, achieving accurate release of therapeutic drugs at the infection site. In vivo experiments showed a 97.7% reduction in bacterial burden, along with promotion of growth factor secretion and regulation of inflammation and angiogenesis. This multifunctional antibacterial platform has potential for treating drug-resistant bacterial infections due to its efficient gas release performance.
Article
Engineering, Environmental
Huixin Wang, Wenshen Wang, Chengpan Li, Ao Xu, Bensheng Qiu, Fenfen Li, Weiping Ding
Summary: This study presented a novel microneedle system loaded with the multipurpose small molecule Flav7 for high-efficiency light-activated drug release for chemotherapy and high-performance light-controlled thermotherapy of tumors, as well as remarkable NIR-II fluorescence imaging to guide chemo-thermal therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Kailun Wei, Kefei Zhao, Yuxia Gao, Hao Zhang, Xia Yu, Min-Hui Li, Jun Hu
Summary: In this study, a near-infrared responsive poly-sulfide carrier (SOCT) was prepared using industrial waste sulfur, bio-based soybean oil, and agricultural waste biochar. The carrier exhibited good photothermal property and stable release behavior, allowing for controlled release of the pesticide. It also showed excellent fungicidal activities and high biosafety for plants and fish. The carrier material can be completely degraded in specific conditions, making it sustainable and multi-functional. This research provides an effective approach for developing pesticide formulations with improved performance.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
M. Kim, J. Choi, S. Y. Kim
Summary: This study focuses on a near-infrared light-tunable hydrogel soft actuator system that can achieve fast and precise mechanical actuation under low-intensity NIR light. By designing a bilayer structure with gold nanorods as a photothermal agent, the hydrogel exhibits rapid bending deformation through photothermally induced phase transition. The NIR-responsive bending actuation of the hydrogel can be precisely controlled by various parameters, showing promising potential for human-robot interaction interface applications.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Shaojing Zhao, Li Yan, Mingyue Cao, Li Huang, Ke Yang, Shuilin Wu, Minhuan Lan, Guangle Niu, Wenjun Zhang
Summary: Carbon dots (CDs) prepared by hydrothermal treatment of coronene derivatives exhibit a high photothermal conversion efficiency at 808 nm, making them suitable as an efficient NIR light-triggered photothermal agent for effective photothermal therapy against cancer.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Jiuyu Cui, Jun Huang, Yonggan Yan, Wenqian Chen, Jie Wen, Xunwei Wu, Jikai Liu, Hanlian Liu, Chuanzhen Huang
Summary: A Fe3O4-loaded photothermal microneedle patch (Fe3O4@MN) has been developed for controlled drug delivery, achieving enhanced drug release efficiency. The Fe3O4@MN has sufficient mechanical strength to penetrate the skin, and its temperature can rapidly increase under NIR irradiation. In vitro experiments showed high drug release rates and increased penetration depth compared to a patch without Fe3O4 nanoparticles, indicating the potential application of the synthesized microneedle patch for transdermal drug delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Cheng Xu, Kanyi Pu
Summary: Second near-infrared photothermal therapy (NIR-II PTT) has advantages of deeper penetration and less toxicity, but faces challenges of suboptimal photothermal conversion and limited therapeutic efficacy. To improve efficacy, multifunctional NIR-II photothermal inorganic or organic materials have been developed for combination with other therapeutic modalities.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Engineering, Biomedical
Jingwei Pan, Jianjun Du, Qiao Hu, Yuan Liu, Xiaoxue Zhang, Xin Li, Danhong Zhou, Qichao Yao, Saran Long, Jiangli Fan, Xiaojun Peng
Summary: Photothermal therapy (PTT) is a promising approach to cancer treatment. The photothermal conversion ability of Cy7 is efficiently enhanced based on photo-induced electron transfer (PET)-triggered structural deformation. Three Cy7 derivatives, CZ-Cy7, PXZ-Cy7, and PTZ-Cy7, are presented as examples to demonstrate the regulation of the energy release of the excited states.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Kerong Deng, Donglian Liu, Ziyan Wang, Zhaoru Zhou, Qianyi Chen, Jiamin Luo, Yaru Zhang, Zhiyao Hou, Jun Lin
Summary: Development of nanotheranostic agents with near-infrared absorption provides an effective tool for fighting malignant diseases. In this study, a nanoplatform based on gadolinium-ion-doped NdVO4 nanoplates was employed for multiple-imaging-assisted photothermal therapy.
Article
Biotechnology & Applied Microbiology
Taicheng Zhou, Lili Wu, Ning Ma, Fuxin Tang, Jialin Chen, Zhipeng Jiang, Yingru Li, Tao Ma, Na Yang, Zhen Zong
Summary: Near-infrared (NIR) photothermal therapy holds promise as a cancer treatment modality, but its clinical application is limited by inefficient drug release and low tumor accumulation. Researchers have developed a NIR-light triggered nano composite that effectively releases an anticancer drug and accumulates in tumors. In vitro and in vivo experiments demonstrate the potential of this strategy for cancer therapy.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Sidi Zhang, Zhenhua Li, Qingbing Wang, Qian Liu, Wei Yuan, Wei Feng, Fuyou Li
Summary: The study presents a photothermally controlled oxygen release system for delivering oxygen to hypoxic tumors and customizes a programmed cascade therapy strategy to suppress tumor growth.
ADVANCED MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Lijuan Zhu, Ruyan Feng, Gaojian Chen, Chao Wang, Zhuang Liu, Zexin Zhang, Hong Chen
Summary: Cancer cell migration is a crucial step in cancer metastasis. Cell surface engineering can modify cell interactions with the microenvironment and has been shown to affect cell migration. This study demonstrates that modifying the surface of melanoma cells can alter their migration direction and velocity, and suppress the collective migration of unmodified cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Fang Xu, Ziying Fei, Huaxing Dai, Jialu Xu, Qin Fan, Shufang Shen, Yue Zhang, Qingle Ma, Jiacheng Chu, Fei Peng, Fangfang Zhou, Zhuang Liu, Chao Wang
Summary: A technology utilizing mesenchymal stem cell-derived extracellular vesicles has been developed for the treatment of autoimmune diseases, demonstrating significant therapeutic potential by regulating immune cells and reshaping the local inflammatory environment, particularly in ulcerative colitis and psoriasis mouse models.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Huan He, Ziying Fei, Tailin Guo, Yue Hou, Da Li, Kefeng Wang, Fuzeng Ren, Kelong Fan, Daijun Zhou, Chaoming Xie, Chao Wang, Xiong Lu
Summary: This study developed a bioadhesive injectable hydrogel for localized immune modulation and catalytic immunotherapy in cancer treatment. The hydrogel containing a nanozyme and immune adjuvant effectively targeted the tumor microenvironment while limiting systemic exposure and enhancing therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Huaxing Dai, Qin Fan, Ziying Fei, Qingle Ma, Qianyu Yang, Jiacheng Chu, Xuanfang Zhou, Yue Zhang, Ziliang Dong, Fang Xu, Beilei Wang, Rong Sun, Yifan Shen, Ruao Xie, Ruibin Li, Chao Wang
Summary: In this study, we investigated the immune microenvironment of the lung, liver, and spleen following the systemic administration of silica nanoparticles (SiO2 NPs). Our results showed a dramatic decrease in the number of T cells in the lung, coupled with an increase in IL-17-producing T cells frequency, a decrease in the a ss T population, and increased expression of T cells dysfunctional markers.
Article
Chemistry, Multidisciplinary
Yitong Chen, Yue Zhang, Beilei Wang, Qin Fan, Qianyu Yang, Jialu Xu, Huaxing Dai, Fang Xu, Chao Wang
Summary: An implantable blood clot loaded with LPH-vaccine and LPHsiRNA is used to recruit and activate dendritic cells, improving the efficacy of tumor vaccines and reducing immunosuppressive signals. This strategy has shown promising results in mouse models and has the potential for personalized therapy.
Article
Chemistry, Physical
Huaxing Dai, Qianyu Yang, Rong Sun, Yue Zhang, Qingle Ma, Yifan Shen, Beilei Wang, Yitong Chen, Jialu Xu, Bo Tian, Fang Xu, Chao Wang
Summary: This study demonstrates that accumulation of silica nanoparticles in the liver can induce resistance to immune checkpoint blockade therapy by affecting T cell frequency and tumor infiltration. The findings provide a new mechanism insight into ICB resistance.
Article
Chemistry, Multidisciplinary
Mengying He, Mengyuan Wang, Tao Xu, Mengyao Zhang, Huaxing Dai, Chao Wang, Dawei Ding, Zhiyuan Zhong
Summary: Reactive oxygen species (ROS) act as important signaling molecules that can stimulate the immune system. ROS has emerged as a unique therapeutic strategy for malignant tumors because it can directly reduce tumor burden and induce immunogenic cell death (ICD) to trigger immune responses. However, immunosuppressive signals and dysfunction of immune cells within the tumor microenvironment (TME) often downplay the anti-tumor immune responses. Various strategies have been developed to enhance ROS-based cancer immunotherapy, such as combining with immune checkpoint inhibitors, tumor vaccines, and immunoadjuvants, which have shown promising results with limited side effects. This review introduces the concept of ROS-powered cancer immunotherapy, highlights innovative strategies to boost ROS-based cancer immunotherapy, and discusses challenges in clinical translation and future perspectives.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Qianyu Yang, Huaxing Dai, Beilei Wang, Jialu Xu, Yue Zhang, Yitong Chen, Qingle Ma, Fang Xu, Haibo Cheng, Dongdong Sun, Chao Wang
Summary: The study reveals that oral intake of polyethylene (PE) and polystyrene nanoplastics disrupts the intestinal microenvironment in mice, leading to the growth of colorectal tumors. They found that the nanoparticles induce lysosome damage, resulting in the differentiation of colon Treg and Th17 cells associated with T cell exhaustion. This study emphasizes the urgent need to address plastic pollution worldwide.
Article
Cell Biology
Qianyu Yang, Huaxing Dai, Ying Cheng, Beilei Wang, Jialu Xu, Yue Zhang, Yitong Chen, Fang Xu, Qingle Ma, Fang Lin, Chao Wang
Summary: This study investigates the effects of nanoplastics (NPs) on the gut immune landscape and brain immunity. The results demonstrate that NPs have a stronger impact on gut macrophage activation compared to microplastics (MPs). Moreover, NPs induce the reprogramming of gut interleukin-1 (IL-1)-producing macrophages through lysosomal damage, leading to microglial activation and Th17 differentiation in the brain, resulting in cognitive decline and short-term memory impairment in NP-fed mice. These findings provide insight into the mechanism of the gut-brain axis and highlight the global importance of addressing plastic pollution.
Article
Multidisciplinary Sciences
Huan He, Qiaozhen Qin, Fang Xu, Yitong Chen, Shuquan Rao, Chao Wang, Xiaoxia Jiang, Xiong Lu, Chaoming Xie
Summary: Developing oral nanomedicines that suppress intestinal inflammation while modulating gut microbiota and brain interactions is essential for effectively treating inflammatory bowel disease.
Article
Cell Biology
Fang Xu, Dongpeng Jiang, Jialu Xu, Huaxing Dai, Qin Fan, Ziying Fei, Beilei Wang, Yue Zhang, Qingle Ma, Qianyu Yang, Yitong Chen, Edikan A. Ogunnaike, Jianhong Chu, Chao Wang
Summary: In this study, bispecific extracellular vesicles (EVs) were developed by genetically engineering dendritic cells (DCs) to simultaneously target tumor antigens and block immune checkpoint proteins. These bispecific EVs showed an impressive ability to accumulate in solid tumors and modify the immune landscape, preventing the formation of premetastatic niches. This technology has the potential to provide a novel approach for treating various types of tumors and personalized therapy.
Article
Materials Science, Biomaterials
Yi Wu, Heng Wang, Anning Song, Xiaoyu Wang, Qingle Ma, Chenlu Yao, Jialu Xu, Huaxing Dai, Chao Wang, Ting Lu, Fang Xu
Summary: In this study, we developed MSC-EVs-PD-L1 for the treatment of LPS-induced pneumonia by intratracheal administration. We found that the upregulation of PD-L1 expression can exert immunosuppressive effects through the PD-1/PD-L1 signaling pathway, and intratracheal administration showed better therapeutic efficacy in the lungs of mice compared to systemic administration.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Bo Tian, Jinyu Bai, Lei Sheng, Hao Chen, Wenju Chang, Yue Zhang, Chenlu Yao, Chenmeng Zhou, Xiaoyu Wang, Huajian Shan, Qirong Dong, Chao Wang, Xiaozhong Zhou
Summary: Bone homeostasis is crucial for maintaining healthy bone tissue. P7C3, a substance that regulates multiple signaling pathways, suppresses bone resorption and promotes bone formation, potentially offering a new treatment for osteoporosis.
Article
Cell Biology
Qingle Ma, Chenhui Weng, Chenlu Yao, Jialu Xu, Bo Tian, Yi Wu, Heng Wang, Qianyu Yang, Huaxing Dai, Yue Zhang, Fang Xu, Xiaolin Shi, Chao Wang
Summary: Severe pneumonia may lead to long-term effects including sequelae and accelerated aging, but the mechanism is not well understood and requires further research. This study found that mice recovered from severe pneumonia exhibited lung immunosenescence, characterized by an imbalanced naive-memory ratio of T lymphocytes in the lung. The reduction of naive T cells is associated with decreased immune response and is a key change in the aging process. The results also suggest a link between severe pneumonia and the aging process, mediated by disrupted T cell homeostasis in the lungs following pneumonia.
Review
Materials Science, Biomaterials
Chenlu Yao, Chao Wang
Summary: Platelet-derived extracellular vesicles (PEVs) are released from platelets and play a critical role in hemostasis and thrombosis. Recent research has shown that PEVs have important functions in inflammation, angiogenesis, and cancer. PEVs have been utilized as drug delivery platforms, targeting inflammatory sites both passively and actively. This review summarizes the biological function of PEVs, recent applications in targeted drug delivery, and future development prospects.
BIOMATERIALS SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
