Article
Microbiology
Zhenhua Wu, Shimeng Huang, Tiantian Li, Na Li, Dandan Han, Bing Zhang, Zhenjiang Zech Xu, Shiyi Zhang, Jiaman Pang, Shilan Wang, Guolong Zhang, Jiangchao Zhao, Junjun Wang
Summary: The study found that oral EGCG helps alleviate colonic inflammation by increasing the abundance of Akkermansia, a short-chain fatty acids-producing bacteria, and promoting SCFAs production. Prophylactic supplementation of EGCG also showed beneficial outcomes. FMT experiments confirmed the role of EGCG in attenuating colitis.
Review
Immunology
Xi Chen, Nanxi Wang, Jiannan Wang, Binyou Liao, Lei Cheng, Biao Ren
Summary: In the human body, different microbial habitats exhibit distinct microbial population patterns and play a crucial role in the development of diseases. The oral cavity and gut are complex and interdependent microbial habitats, with Helicobacter pylori being one of the most important pathogens from the digestive tract. H. pylori infections can disrupt the normal gastric environment and enhance microbial interactions between the oral cavity and gut, thus reshaping the oral and gut microbiomes. The interaction between the oral-gut axis microbiota and H. pylori plays a significant role in H. pylori's colonization, infection, and pathogenicity. The balance of the microecology of the oral-gut axis can be altered by both H. pylori infection and eradication, which can impact the occurrence and progress of related diseases. The shift of oral-gut axis microbiota and their interactions with H. pylori may serve as potential targets for the diagnosis and treatment of H. pylori infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ciliang Guo, Yeqing Wang, Shihai Zhang, Xiuqi Zhang, Zhenyun Du, Meixia Li, Kan Ding
Summary: This study found that the polysaccharide HAW1-2 from hawthorn can alleviate colitis in mice by regulating inflammatory cytokines and inhibiting related molecular pathways. Additionally, HAW1-2 can modify the composition of gut microbiota, promoting the proliferation of beneficial bacteria and generating beneficial short-chain fatty acids to inhibit colitis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Gastroenterology & Hepatology
Xin Wen, Hong-Gang Wang, Min-Na Zhang, Meng-Hui Zhang, Han Wang, Xiao-Zhong Yang
Summary: Recent studies have demonstrated the therapeutic effects of FMT on mice with experimental colitis and patients with UC, suggesting that FMT can ameliorate colitis by regulating the gut microbiota and modulating T-cell responses.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Pharmacology & Pharmacy
Yonghyun Lee, Nobuhiko Kamada, James J. Moon
Summary: The gastrointestinal tract plays a crucial role in both local and systemic diseases, influenced by factors like the mucosal immune system, intestinal barrier, and gut microbiota. Selective drug delivery for oral vaccines, immune tolerance, and inflammatory diseases faces challenges due to the physiological and biological barriers of the GIT. Advances in oral nanomedicine offer potential solutions for overcoming these barriers and effectively targeting treatments to the GIT.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Nutrition & Dietetics
Yiying Zhao, Qing Jiang
Summary: Accumulating evidence suggests that polyphenols can promote beneficial gut bacteria growth, alleviate colonic diseases such as colitis and colorectal cancer, and alter the composition and function of the gut microbiota. Polyphenols increase levels of butyrate producers and probiotics, while decreasing opportunistic pathogenic or proinflammatory microbes in the gut, thereby protecting against inflammation and cancer. Polyphenol metabolites produced by the gut microbiota have anticancer and anti-inflammatory activities, contributing to the protective effects of polyphenols on colitis and colorectal cancer.
ADVANCES IN NUTRITION
(2021)
Review
Endocrinology & Metabolism
Julie Rodriguez, Nathalie M. Delzenne
Summary: Prebiotics modulate the metabolic cross-talk communication between the gut, the adipose tissue, and skeletal muscles by regulating the gut microbiota and endocrine functions.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Food Science & Technology
Bo Yang, Mingjie Li, Shuo Wang, R. Paul Ross, Catherine Stanton, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: Lactobacillus ruminis showed immune regulatory effects in DSS-induced colitis mice by reducing pro-inflammatory cytokines and increasing short chain fatty acids, ultimately improving the imbalance of gut microbiota composition.
Article
Immunology
Yonggang Huang, Miaomiao Wu, Hao Xiao, Hongnan Liu, Guan Yang
Summary: This study suggests that MES treatment can alleviate DSS-induced ulcerative colitis in piglets by reducing symptoms, improving intestinal microbiota, and regulating immune cell function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Manorama Kumari, Parul Singh, Basavaprabhu H. Nataraj, Anusha Kokkiligadda, Harshita Naithani, Syed Azmal Ali, Pradip. Behare, Ravinder Nagpal
Summary: Emerging evidence and understanding of the microbiome have identified beneficial commensals known as next-generation probiotics. Specific dietary interventions can modulate the abundance and activity of these beneficial bacteria in the gut, and combining specific probiotic-targeted diets can enhance their effectiveness.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Marco Fabbrini, Federica D'Amico, Monica Barone, Gabriele Conti, Mariachiara Mengoli, Patrizia Brigidi, Silvia Turroni
Summary: Nutraceuticals have gained much attention recently due to their potential role in preventing chronic diseases. However, there is limited research on their bioavailability. While consuming these compounds at pharmacological levels can significantly increase their plasma concentration, positive effects have been observed even with regular dietary consumption. This may be attributed to the activity of metabolites produced by gut microbiota fermentation.
Article
Food Science & Technology
Baixi Zhang, Xinwen Huang, Lijuan Niu, Xuemei Chen, Bo Hu, Xiaoshu Tang
Summary: This study found that Lonicera caerulea pomace (LCP)-supplemented diets can alleviate the symptoms of Dextran Sulfate Sodium (DSS)-induced colitis and exert effects through multiple mechanisms, including anti-inflammation, intestinal barrier repair, and modulation of gut microbiota composition. This suggests the potential importance of LCP in promoting intestinal health.
Article
Chemistry, Applied
Jianjun Zhou, Min Wang, Christine Bauerl, Erika Cortes-Macias, Joaquim Calvo-Lerma, Maria Carmen Collado, Francisco J. Barba
Summary: This study evaluated the impact of microalgal extracts from Spirulina, Chlorella, and Phaeodactylum tricornutum obtained by pressurized liquid extraction (PLE) on antioxidant and anti-inflammatory activities, microbial growth, and in vitro gut microbiota composition. PLE resulted in a significant increase in proteins, carbohydrates, polyphenols, and antioxidant capacities of the extracts compared to conventional extraction. The extracts from Spirulina and P. tricornutum showed reduced activation of the inflammatory NF-Kappa B pathway and inhibited the growth of pathogenic bacteria while promoting the growth of beneficial strains. The digestion of microalgal biomolecules led to the release of short-chain fatty acids during in vitro colonic microbiota fermentation, indicating potential health benefits for the human gut.
Article
Food Science & Technology
Adrian Cortes-Martin, Carlos Eduardo Iglesias-Aguirre, Amparo Meoro, Maria Victoria Selma, Juan Carlos Espin
Summary: The study found that pomegranate extract nutraceutical has an effect on the gut microbiota in poly-medicated MetS patients, particularly in anti-hypertensive treatments. This provides a new complementary approach for MetS therapy.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Xian Hu, Xinmiao He, Can Peng, Yiwen He, Chenyu Wang, Wenjie Tang, Heshu Chen, Yanzhong Feng, Di Liu, Tiejun Li, Liuqin He
Summary: The study found that dietary supplementation of aspartate (Asp) can alleviate DSS-induced colitis by improving colonic morphology, reducing oxidative stress and cell apoptosis, and modulating the gut microbiota composition. Asp may also enhance immunity, regulate RIPK signaling, and improve antioxidative capacity to promote the recovery of colonic damage.
Article
Chemistry, Physical
Huaxing Dai, Qianyu Yang, Rong Sun, Yue Zhang, Qingle Ma, Yifan Shen, Beilei Wang, Yitong Chen, Jialu Xu, Bo Tian, Fang Xu, Chao Wang
Summary: This study demonstrates that accumulation of silica nanoparticles in the liver can induce resistance to immune checkpoint blockade therapy by affecting T cell frequency and tumor infiltration. The findings provide a new mechanism insight into ICB resistance.
Review
Chemistry, Multidisciplinary
Chaoming Xie, Yazhen Li, Xiaochuan Guo, Yonghui Ding, Xiong Lu, Shuquan Rao
Summary: The immune system plays a crucial role in protecting the body from pathogens and tumor cells while promoting tissue repair and anti-tumor activity. Systemic administration of immune agents often leads to non-specific immune activity and autoimmune complications. To address this issue, local immunomodulation using adhesive hydrogels, specifically mussel-inspired adhesive hydrogels, has been developed. These hydrogels provide targeted and controlled release of immune agents, with regulatory effects on local immune cells, maximizing therapeutic outcomes and minimizing impact on overall immune balance. This review covers the current knowledge on immune response in tissue repair and tumor therapy, the design strategies of adhesive hydrogels, and the molecular structure and immunomodulatory mechanisms of mussel-inspired adhesive hydrogels.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Correction
Chemistry, Multidisciplinary
Yue Hou, Yazhen Li, Yingqi Li, Da Li, Tailin Guo, Xu Deng, Hongping Zhang, Chaoming Xie, Xiong Lu
Article
Chemistry, Multidisciplinary
Junchang Guo, Liansong Ye, Yuan Gao, Shuangyang Li, Lifan Zhang, Wei Liu, Tingfa Peng, Yi Mou, Chuncheng Wu, Chaoming Xie, Bing Hu, Xu Deng
Summary: In this study, a hybrid dry powder (HDP) strategy is proposed for rapid sealing of wet tissues during gastric endoscopic submucosal dissection (ESD). The HDPs form a hydrogel layer over the target tissue by absorbing water and forming electrostatic interactions, achieving strong adhesion through hydrogen bonding. The HDP-assembled hydrogel demonstrates fast adhesion to wet tissues, low swelling rate, and resistance to acidic degradation.
Article
Chemistry, Multidisciplinary
Qianyu Yang, Huaxing Dai, Beilei Wang, Jialu Xu, Yue Zhang, Yitong Chen, Qingle Ma, Fang Xu, Haibo Cheng, Dongdong Sun, Chao Wang
Summary: The study reveals that oral intake of polyethylene (PE) and polystyrene nanoplastics disrupts the intestinal microenvironment in mice, leading to the growth of colorectal tumors. They found that the nanoparticles induce lysosome damage, resulting in the differentiation of colon Treg and Th17 cells associated with T cell exhaustion. This study emphasizes the urgent need to address plastic pollution worldwide.
Article
Cell Biology
Qianyu Yang, Huaxing Dai, Ying Cheng, Beilei Wang, Jialu Xu, Yue Zhang, Yitong Chen, Fang Xu, Qingle Ma, Fang Lin, Chao Wang
Summary: This study investigates the effects of nanoplastics (NPs) on the gut immune landscape and brain immunity. The results demonstrate that NPs have a stronger impact on gut macrophage activation compared to microplastics (MPs). Moreover, NPs induce the reprogramming of gut interleukin-1 (IL-1)-producing macrophages through lysosomal damage, leading to microglial activation and Th17 differentiation in the brain, resulting in cognitive decline and short-term memory impairment in NP-fed mice. These findings provide insight into the mechanism of the gut-brain axis and highlight the global importance of addressing plastic pollution.
Article
Nanoscience & Nanotechnology
Chaoming Xie, Jiaqing Luo, Yongjie Luo, Jie Zhou, Xiaochuan Guo, Xiong Lu
Summary: This study reports a mussel-inspired approach to design a near-infrared light-responsive antibacterial hydrogel wound dressing. The hydrogel dressing possesses on-demand antibacterial and excellent wound repair properties, as well as conductivity and cell affinity. In vitro and in vivo studies demonstrated its strong tissue repair activity under near-infrared light irradiation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jinglei Gong, Chengxinyue Ye, Jinhui Ran, Xin Xiong, Xinyi Fang, Xueman Zhou, Yating Yi, Xiong Lu, Jun Wang, Chaoming Xie, Jin Liu
Summary: The study describes a silk fibroin/gelatin patch incorporating polydopamine-mediated ultralong silk microfibers and metformin-loaded zeolitic imidazolate framework, which promotes periodontal soft and hard tissue regeneration by regulating the immunomodulatory microenvironment. The patch has reactive oxygen species-scavenging ability and anti-inflammatory activity, reducing the inflammatory response and improving periodontal ligament reconstruction. The sustained release of metformin and zinc ions from the patch confers anti-aging and immunomodulatory abilities, promoting bone regeneration.
Article
Cell Biology
Fang Xu, Dongpeng Jiang, Jialu Xu, Huaxing Dai, Qin Fan, Ziying Fei, Beilei Wang, Yue Zhang, Qingle Ma, Qianyu Yang, Yitong Chen, Edikan A. Ogunnaike, Jianhong Chu, Chao Wang
Summary: In this study, bispecific extracellular vesicles (EVs) were developed by genetically engineering dendritic cells (DCs) to simultaneously target tumor antigens and block immune checkpoint proteins. These bispecific EVs showed an impressive ability to accumulate in solid tumors and modify the immune landscape, preventing the formation of premetastatic niches. This technology has the potential to provide a novel approach for treating various types of tumors and personalized therapy.
Article
Materials Science, Biomaterials
Yi Wu, Heng Wang, Anning Song, Xiaoyu Wang, Qingle Ma, Chenlu Yao, Jialu Xu, Huaxing Dai, Chao Wang, Ting Lu, Fang Xu
Summary: In this study, we developed MSC-EVs-PD-L1 for the treatment of LPS-induced pneumonia by intratracheal administration. We found that the upregulation of PD-L1 expression can exert immunosuppressive effects through the PD-1/PD-L1 signaling pathway, and intratracheal administration showed better therapeutic efficacy in the lungs of mice compared to systemic administration.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Bo Tian, Jinyu Bai, Lei Sheng, Hao Chen, Wenju Chang, Yue Zhang, Chenlu Yao, Chenmeng Zhou, Xiaoyu Wang, Huajian Shan, Qirong Dong, Chao Wang, Xiaozhong Zhou
Summary: Bone homeostasis is crucial for maintaining healthy bone tissue. P7C3, a substance that regulates multiple signaling pathways, suppresses bone resorption and promotes bone formation, potentially offering a new treatment for osteoporosis.
Article
Cell Biology
Qingle Ma, Chenhui Weng, Chenlu Yao, Jialu Xu, Bo Tian, Yi Wu, Heng Wang, Qianyu Yang, Huaxing Dai, Yue Zhang, Fang Xu, Xiaolin Shi, Chao Wang
Summary: Severe pneumonia may lead to long-term effects including sequelae and accelerated aging, but the mechanism is not well understood and requires further research. This study found that mice recovered from severe pneumonia exhibited lung immunosenescence, characterized by an imbalanced naive-memory ratio of T lymphocytes in the lung. The reduction of naive T cells is associated with decreased immune response and is a key change in the aging process. The results also suggest a link between severe pneumonia and the aging process, mediated by disrupted T cell homeostasis in the lungs following pneumonia.
Article
Chemistry, Multidisciplinary
Donglin Gan, Ziqiang Huang, Xiao Wang, Dejia Xu, Shuquan Rao, Kefeng Wang, Fuzeng Ren, Lili Jiang, Chaoming Xie, Xiong Lu
Summary: This study proposes a mussel-inspired method for preparing a specific core-shell redox-active system, consisting of a polydopamine (PDA) modified zeolitic imidazolate framework 71 (ZIF-71) core, and a poly 3,4-ethylenedioxythiopene (PEDOT) shell. The core-shell PEDOT@PZIF-71 system provides the hydrogel with stretchability and adhesiveness, and can be applied as a functional electrode for bioelectronics and supercapacitors.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Fanxi Sun, Ang Gao, Xiaoyu Xiong, Yongli Duan, Dacheng Dai, Yifei Zhu, Chaoming Xie, Qiang Wei, Longquan Chen, Bo He, Hui Zhao, Yonghao Zheng, Xu Deng, Chen Wei, Dongsheng Wang
Summary: In this study, grayscale information encryption was achieved by controlling the kinetics of photoisomerization of donor-acceptor Stenhouse adducts on a paper surface, based on the photochromism of ester-containing molecules.
CHEMICAL COMMUNICATIONS
(2023)
