Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

(2022) Kelly Kersten et al.   CANCER CELL

Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity

(2022) Rita Perelroizen et al.   BRAIN

Mitochondrial Dysfunction, Macrophage, and Microglia in Brain Cancer

(2021) Rongze Olivia Lu et al.   Frontiers in Cell and Developmental Biology

Lipid signalling enforces functional specialization of Treg cells in tumours

(2021) Seon Ah Lim et al.   NATURE

Prospects of antibodies targeting CD47 or CD24 in the treatment of glioblastoma

(2021) Hao Wu et al.   CNS Neuroscience & Therapeutics

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

(2021) Yongfeng Song et al.   Cell Metabolism

An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma

(2021) Bo Xu et al.   Nature Communications

Dysregulation of cholesterol homeostasis in human lung cancer tissue and tumour-associated macrophages

(2021) Jessica Hoppstädter et al.   EBioMedicine

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

(2020) Christina A. von Roemeling et al.   Nature Communications

M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer

(2020) Eva M Garrido-Martin et al.   Journal for ImmunoTherapy of Cancer

T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection

(2020) E. Ashley Moseman et al.   Science Immunology

Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma

(2019) Gregor Hutter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncolytic viruses: how “lytic” must they be for therapeutic efficacy?

(2019) Maria Eugenia Davola et al.   OncoImmunology

Targeting cholesterol metabolism in glioblastoma: a new therapeutic approach in cancer therapy

(2019) Leila Pirmoradi et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

(2019) Pieter Goossens et al.   Cell Metabolism

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

Mechanisms of immunotherapy resistance: lessons from glioblastoma

(2019) Christopher M. Jackson et al.   NATURE IMMUNOLOGY

Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer

(2019) Georgila et al.   Cancers

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

(2019) Marian L. Burr et al.   CANCER CELL

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance

(2019) Dayana B. Rivadeneira et al.   IMMUNITY

Recombinant Adenovirus Expressing a Soluble Fusion Protein PD-1/CD137L Subverts the Suppression of CD8+ T Cells in HCC

(2019) Yonghui Zhang et al.   MOLECULAR THERAPY

7-Ketocholesterol in disease and aging

(2019) Amelia Anderson et al.   Redox Biology

Energy metabolism manipulates the fate and function of tumour myeloid-derived suppressor cells

(2019) Cong Hu et al.   BRITISH JOURNAL OF CANCER

Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint

(2019) Erik Voets et al.   Journal for ImmunoTherapy of Cancer

Macrophages and lipid metabolism

(2018) Anneleen Remmerie et al.   CELLULAR IMMUNOLOGY

Granulocyte macrophage-colony stimulating factor: A key modulator of renal mononuclear phagocyte plasticity

(2018) Katie J. Mylonas et al.   IMMUNOBIOLOGY

Anti-CD24 neutralizing antibody exacerbates Concanavalin A-induced acute liver injury in mice via liver M1 macrophages

(2017) Hongyu Liu et al.   IMMUNOLOGY LETTERS

Adult Glioblastoma

(2017) Brian M. Alexander et al.   JOURNAL OF CLINICAL ONCOLOGY

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Ten principles of heterochromatin formation and function

(2017) Robin C. Allshire et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

(2017) Heather A. Ferris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of submitochondrial protein distribution

(2017) F.-Nora Vögtle et al.   Nature Communications

Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review

(2017) Erdi Sozen et al.   Redox Biology

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

(2016) Genaro R. Villa et al.   CANCER CELL

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Division of labor in transhydrogenase by alternating proton translocation and hydride transfer

(2015) J. H. Leung et al.   SCIENCE

Astrocyte׳s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1

(2014) Jin-ichi Ito et al.   BRAIN RESEARCH

Stable luciferase expression does not alter immunologic or in vivo growth properties of GL261 murine glioma cells

(2014) Aaron J Clark et al.   Journal of Translational Medicine

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

(2013) D. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phagocytosis: Coupling of Mitochondrial Uncoupling and Engulfment

(2011) Grazia M. Cereghetti et al.   CURRENT BIOLOGY

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

(2011) D. Guo et al.   Cancer Discovery

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR-623, a Novel Liver X-Receptor Agonist, in Healthy Participants

(2009) Arie Katz et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Tyrosine Kinase Inhibitor AG126 Reduces 7-Ketocholesterol-Induced Cell Death by Suppressing Mitochondria-Mediated Apoptotic Process

(2009) Yun Jeong Kim et al.   NEUROCHEMICAL RESEARCH

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

(2008) Sylwia Michlewska et al.   FASEB JOURNAL

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytochrome c: functions beyond respiration

(2008) Yong-Ling P. Ow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY