The short-chain fatty acid crotonate reduces invasive growth and immune escape of Candida albicans by regulating hyphal gene expression

Systematic analysis of lysine crotonylation in human macrophages responding to MRSA infection

(2023) Hao Zhang et al.   Frontiers in Cellular and Infection Microbiology

CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair

(2022) Enas R. Abu-Zhayia et al.   MOLECULAR CELL

Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development

(2022) Shang-Kun Dai et al.   DEVELOPMENT

The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways

(2022) Françios A.B. Olivier et al.   Cell Reports

Sodium butyrate mediates histone crotonylation and alleviated neonatal rats hypoxic–ischemic brain injury through gut–brain axis

(2022) Xuejia He et al.   Frontiers in Microbiology

Systematic Analysis of the Lysine Crotonylome and Multiple Posttranslational Modification Analysis (Acetylation, Succinylation, and Crotonylation) in Candida albicans

(2021) Xiaowei Zhou et al.   mSystems

Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters

(2021) Shang‐Kun Dai et al.   EMBO REPORTS

Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

(2021) Mengqing Gao et al.   Cell Reports

Toxoplasma gondii Infection Inhibits Histone Crotonylation to Regulate Immune Response of Porcine Alveolar Macrophages

(2021) Jing Yang et al.   Frontiers in Immunology

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

(2021) Xionghui Ding et al.   Nature Communications

On and Off: Epigenetic Regulation of C. albicans Morphological Switches

(2021) Elise Iracane et al.   Pathogens

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen

(2020) Qi Wang et al.   Cell Reports

Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection

(2020) Timothy M. Tucey et al.   PLoS Pathogens

Lysosome Fusion Maintains Phagosome Integrity during Fungal Infection

(2020) Johannes Westman et al.   Cell Host & Microbe

Histone acylation marks respond to metabolic perturbations and enable cellular adaptation

(2020) Chanhee Jo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways

(2019) Raju Shivarathri et al.   Scientific Reports

Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription

(2019) Leonie Kollenstart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression

(2019) Graeme J. Gowans et al.   MOLECULAR CELL

Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

(2018) Timothy M. Tucey et al.   Cell Metabolism

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

(2018) Rachel Fellows et al.   Nature Communications

Invasive candidiasis

(2018) Peter G. Pappas et al.   Nature Reviews Disease Primers

Merge and separation of NuA4 and SWR1 complexes control cell fate plasticity in Candida albicans

(2018) Xiongjun Wang et al.   Cell Discovery

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

(2018) Johannes Westman et al.   mBio

A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

(2018) Barbara Koch et al.   Cell Reports

Characterization of histone acylations links chromatin modifications with metabolism

(2017) Johayra Simithy et al.   Nature Communications

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

YEATS2 is a selective histone crotonylation reader

(2016) Dan Zhao et al.   CELL RESEARCH

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

(2016) Yuanyuan Li et al.   MOLECULAR CELL

The Taf14 YEATS domain is a reader of histone crotonylation

(2016) Forest H Andrews et al.   Nature Chemical Biology

Candida albicans cell-type switching and functional plasticity in the mammalian host

(2016) Suzanne M. Noble et al.   NATURE REVIEWS MICROBIOLOGY

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone Deacetylases and Their Inhibition in Candida Species

(2016) Cécile Garnaud et al.   Frontiers in Microbiology

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications

(2015) E. Megan Flynn et al.   STRUCTURE

Candida albicansUtilizes a Modified β-Oxidation Pathway for the Degradation of Toxic Propionyl-CoA

(2014) Christian Otzen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

(2014) Lunzhi Dai et al.   Nature Chemical Biology

The Pathogen Candida albicans Hijacks Pyroptosis for Escape from Macrophages

(2014) N. Uwamahoro et al.   mBio

Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages

(2013) Melanie Wellington et al.   EUKARYOTIC CELL

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

A genome-wide transcriptional analysis of morphology determination in Candida albicans

(2012) Patricia L. Carlisle et al.   MOLECULAR BIOLOGY OF THE CELL

A Histone Deacetylase Adjusts Transcription Kinetics at Coding Sequences during Candida albicans Morphogenesis

(2012) Denes Hnisz et al.   PLoS Genetics

A GATA Transcription Factor Recruits Hda1 in Response to Reduced Tor1 Signaling to Establish a Hyphal Chromatin State in Candida albicans

(2012) Yang Lu et al.   PLoS Pathogens

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Sodium butyrate inhibits pathogenic yeast growth and enhances the functions of macrophages

(2011) L. N. Nguyen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Hyphal Development in Candida albicans Requires Two Temporally Linked Changes in Promoter Chromatin for Initiation and Maintenance

(2011) Yang Lu et al.   PLOS BIOLOGY

The Fungal Genetics Stock Center: a repository for 50 years of fungal genetics research

(2010) K. McCluskey et al.   JOURNAL OF BIOSCIENCES

HOS2 and HDA1 Encode Histone Deacetylases with Opposing Roles in Candida albicans Morphogenesis

(2010) Lucia F. Zacchi et al.   PLoS One

YEATS domain proteins: a diverse family with many links to chromatin modification and transcriptionThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

(2009) Julia M. Schulze et al.   Biochemistry and Cell Biology

Reduction of fumarate, mesaconate and crotonate by Mfr, a novel oxygen-regulated periplasmic reductase inCampylobacter jejuni

(2009) Edward Guccione et al.   ENVIRONMENTAL MICROBIOLOGY

Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

(2009) S. Joly et al.   JOURNAL OF IMMUNOLOGY

A Phenotypic Profile of the Candida albicans Regulatory Network

(2009) Oliver R. Homann et al.   PLoS Genetics

UME6, a Novel Filament-specific Regulator of Candida albicans Hyphal Extension and Virulence

(2008) Mohua Banerjee et al.   MOLECULAR BIOLOGY OF THE CELL

Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence

(2008) P. L. Carlisle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA