Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection

Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae

(2019) Ona Rogiers et al.   mBio

Central metabolic interactions of immune cells and microbes: prospects for defeating infections

(2019) Ana Traven et al.   EMBO REPORTS

Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

(2018) Timothy M. Tucey et al.   Cell Metabolism

The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory

(2018) Moritz M. Gaidt et al.   JOURNAL OF MOLECULAR BIOLOGY

A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

(2018) Kristy Koselny et al.   mBio

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

(2018) Lydia Kasper et al.   Nature Communications

A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome

(2018) Anukriti Mathur et al.   Nature Microbiology

NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans

(2017) Elena Roselletti et al.   Scientific Reports

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis

(2017) Jorge Domínguez-Andrés et al.   PLoS Pathogens

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Association of a variable number tandem repeat in the NLRP3 gene in women with susceptibility to RVVC

(2016) M. Jaeger et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

(2016) Laura E Sanman et al.   eLife

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals

(2016) Timothy M. Tucey et al.   mSphere

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra

(2015) Monica Borghi et al.   Cell Host & Microbe

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation

(2015) Johji Nomura et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Transcriptomic Analysis of Vulvovaginal Candidiasis Identifies a Role for the NLRP3 Inflammasome

(2015) Vincent M. Bruno et al.   mBio

Global analysis of fungal morphology exposes mechanisms of host cell escape

(2015) Teresa R. O’Meara et al.   Nature Communications

Genetic and phenotypic intra-species variation inCandida albicans

(2014) Matthew P. Hirakawa et al.   GENOME RESEARCH

The Pathogen Candida albicans Hijacks Pyroptosis for Escape from Macrophages

(2014) N. Uwamahoro et al.   mBio

Microbial Egress: A Hitchhiker's Guide to Freedom

(2014) Ana Traven et al.   PLoS Pathogens

Antimicrobial functions of inflammasomes

(2013) Kaiwen W Chen et al.   CURRENT OPINION IN MICROBIOLOGY

Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages

(2013) Melanie Wellington et al.   EUKARYOTIC CELL

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Staphylococcus aureus α-Hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome

(2012) Chahnaz Kebaier et al.   JOURNAL OF INFECTIOUS DISEASES

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Candida albicans Morphogenesis Is Not Required for Macrophage Interleukin 1  Production

(2012) M. Wellington et al.   mBio

The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis

(2011) Frank L. van de Veerdonk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Critical Roles of ASC Inflammasomes in Caspase-1 Activation and Host Innate Resistance to Streptococcus pneumoniae Infection

(2011) R. Fang et al.   JOURNAL OF IMMUNOLOGY

The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

(2011) Shih-Chin Cheng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammasome-dependent Pyroptosis and IL-18 Protect against Burkholderia pseudomallei Lung Infection while IL-1β Is Deleterious

(2011) Ivonne Ceballos-Olvera et al.   PLoS Pathogens

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Fungal pathogen recognition by the NLRP3 inflammasome

(2010) Sophie Joly et al.   Virulence

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

(2009) S. Joly et al.   JOURNAL OF IMMUNOLOGY

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans

(2009) Christopher Askew et al.   PLoS Pathogens