d-Amino acids: new clinical pathways for brain diseases

Dose dependent augmentation of neuroplasticity-based auditory learning in schizophrenia: a double-blind, placebo-controlled, randomized, target engagement clinical trial of the N-methyl-D-aspartate-type glutamate receptor (NMDAR) agonist d-serine

(2023) Pejman Sehatpour et al.   BIOLOGICAL PSYCHIATRY

Information-Rich, Dual-Function 13C/2H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme “Partitioning Fingerprint” and Reveals Disparate Chemotypes for hSR Inhibition

(2023) Stephany M. Ramos de Dios et al.   Journal of the American Chemical Society

Chiral Amino Acid Profiling in Serum Reveals Potential Biomarkers for Alzheimer’s Disease

(2023) Mingxia Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients

(2023) Anna Di Maio et al.   NEUROBIOLOGY OF DISEASE

The D-amino acid oxidase inhibitor luvadaxistat improves mismatch negativity in patients with schizophrenia in a randomized trial

(2023) Patricio O’Donnell et al.   NEUROPSYCHOPHARMACOLOGY

Sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress in chemogenetic transgenic mouse lines

(2023) Shambhu Yadav et al.   Nature Communications

Hypothalamic Menin regulates systemic aging and cognitive decline

(2023) Lige Leng et al.   PLOS BIOLOGY

Serine Racemase mediates subventricular zone neurogenesis via fatty acid metabolism

(2023) Robin Roychaudhuri et al.   Stem Cell Reports

Detection and analysis of chiral molecules as disease biomarkers

(2023) Yaoran Liu et al.   Nature Reviews Chemistry

Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice

(2023) Xiance Ni et al.   Frontiers in Aging Neuroscience

Effects of Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, on Perceived Stress and Cognitive Function Among Patients With Late-Life Depression: A Randomized, Double-Blind, Sertraline- and Placebo-Controlled Trial

(2022) Chieh-Hsin Lin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Complex processes underlying the dynamic changes of D-serine level in AD brains

(2022) Xiance Nia et al.   Current Alzheimer Research

Blood D-Amino Acid Oxidase Levels Increased With Cognitive Decline Among People With Mild Cognitive Impairment: A Two-Year Prospective Study

(2022) Chieh-Hsin Lin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cerebrospinal fluid amino acids glycine, serine, and threonine in nonketotic hyperglycinemia

(2022) Michael A. Swanson et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Alanine serine cysteine transporter (ASCT) substrate binding site properties probed with hydroxyhomoserine esters

(2022) Elias Ndaru et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder

(2022) Naushaba Hasin et al.   MOLECULAR PSYCHIATRY

Profiling of d ‐alanine production by the microbial isolates of rat gut microbiota

(2022) Cindy J. Lee et al.   FASEB JOURNAL

Astrocytic d ‐amino acid oxidase degrades d ‐serine in the hindbrain

(2022) Yusuke Gonda et al.   FEBS LETTERS

D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans

(2022) Barbara Lombardo et al.   Translational Psychiatry

Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus

(2022) Elisa Maffioli et al.   Cell Reports

Endogenous d-serine exists in the mammalian brain independent of synthesis by serine racemase

(2022) Akina Osaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endogenous antioxidants predicted outcome and increased after treatment: A benzoate dose‐finding, randomized, double‐blind, placebo‐controlled trial for Alzheimer's disease

(2022) Hsien‐Yuan Lane et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning

(2022) Kirsten Bohmbach et al.   Nature Communications

Efficacy of N-methyl-D-aspartate receptor modulator augmentation in schizophrenia: A meta-analysis of randomised, placebo-controlled trials

(2021) Kah Kheng Goh et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Serum d-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker

(2021) Luciano Piubelli et al.   Translational Psychiatry

Mouse strain specificity of DAAO inhibitors‐mediated antinociception

(2021) Hao Liu et al.   Pharmacology Research & Perspectives

Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction

(2021) David D. Aguilar et al.   Scientific Reports

Impairment of Executive Functions Associated With Lower D-Serine Serum Levels in Patients With Schizophrenia

(2021) Jaromir Hons et al.   Frontiers in Psychiatry

D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain

(2021) Evan R. Semenza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine

(2021) Glenn Dallérac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Results of a randomized double‐blind study evaluating luvadaxistat in adults with Friedreich ataxia

(2021) Hao Wang et al.   Annals of Clinical and Translational Neurology

D-Serine: A Cross Species Review of Safety

(2021) Amir Meftah et al.   Frontiers in Psychiatry

Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism

(2021) Loredano Pollegioni et al.   Frontiers in Molecular Biosciences

D-amino acids as novel blood-based biomarkers

(2021) Giulia Murtas et al.   CURRENT MEDICINAL CHEMISTRY

Causal effect of insulin resistance on small vessel stroke and Alzheimer's disease: A Mendelian randomization analysis

(2021) Mengyuan Zhou et al.   EUROPEAN JOURNAL OF NEUROLOGY

d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens

(2021) Zhenzhen Chen et al.   MOLECULAR MEDICINE

Physiopathological Relevance of D-Serine in the Mammalian Cochlea

(2021) Jing Wang et al.   Frontiers in Cellular Neuroscience

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

(2020) Juliette Le Douce et al.   Cell Metabolism

Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism

(2020) Afaf Mikou et al.   Scientific Reports

Conformational flexibility within the small domain of human serine racemase

(2020) Chloe R. Koulouris et al.   Acta Crystallographica Section F-Structural Biology Communications

Metabolic epilepsies amenable to ketogenic therapies: Indications, contraindications, and underlying mechanisms

(2020) Cezar Gavrilovici et al.   JOURNAL OF INHERITED METABOLIC DISEASE

D-serine mitigates cell loss associated with temporal lobe epilepsy

(2020) Stephen Beesley et al.   Nature Communications

Transport of Amino Acids Across the Blood-Brain Barrier

(2020) Rosa Zaragozá   Frontiers in Physiology

Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse

(2020) Joseph T. Coyle et al.   AMERICAN JOURNAL OF PSYCHIATRY

Dysfunctional d-aspartate metabolism in BTBR mouse model of idiopathic autism

(2020) Tommaso Nuzzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Prenatal and Early Postnatal Cerebral d-Aspartate Depletion Influences l-Amino Acid Pathways, Bioenergetic processes, and Developmental Brain Metabolism

(2020) Manuela Grimaldi et al.   JOURNAL OF PROTEOME RESEARCH

Cerebrospinal Fluid and Serum d-Serine Levels in Patients with Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2020) Chun-Hung Chang et al.   Journal of Clinical Medicine

Synthesis and Biochemical Evaluation of Lid-Open D-Amino Acid Oxidase Inhibitors

(2019) Bence Szilágyi et al.   MOLECULES

[Express] Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy

(2019) Sheu-Ran Choi et al.   Molecular Pain

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments

(2019) Ronald S. Duman et al.   NEURON

D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep

(2019) Xihuimin Dai et al.   Nature Communications

The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients

(2019) Tommaso Nuzzo et al.   Scientific Reports

The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle

(2019) Samah Neame et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

(2019) Darrick T. Balu et al.   NEUROBIOLOGY OF DISEASE

A novel NMDA receptor-based intervention to suppress compulsion-like alcohol drinking

(2019) Scott Andrew Wegner et al.   NEUROPHARMACOLOGY

Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients

(2019) Sarah Louise Nickels et al.   PARKINSONISM & RELATED DISORDERS

D-glutamate, D-serine, and D-alanine differ in their roles in cognitive decline in patients with Alzheimer's disease or mild cognitive impairment

(2019) Chieh-Hsin Lin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

pLG72 levels increase in early phase of Alzheimer’s disease but decrease in late phase

(2019) Chieh-Hsin Lin et al.   Scientific Reports

Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons

(2019) Matteo Fossati et al.   NEURON

Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain

(2019) Sheu-Ran Choi et al.   Frontiers in Pharmacology

Differential involvement of ipsilateral and contralateral spinal cord astrocyte D-serine in carrageenan-induced mirror-image pain: role of σ1 receptors and astrocyte gap junctions

(2018) Hoon-Seong Choi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents

(2018) Laura Walrave et al.   GLIA

Cerebrospinal fluid D -serine concentrations in major depressive disorder negatively correlate with depression severity

(2018) Sayuri Ishiwata et al.   JOURNAL OF AFFECTIVE DISORDERS

SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy

(2018) Hua Tao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Enhancement of Brain d-Serine Mediates Recovery of Cognitive Function after Traumatic Brain Injury

(2018) Sigal Liraz-Zaltsman et al.   JOURNAL OF NEUROTRAUMA

Deletion of serine racemase confers D-serine –dependent resilience to chronic social defeat stress

(2018) Chao Dong et al.   NEUROCHEMISTRY INTERNATIONAL

Astroglial CB 1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory

(2018) Laurie M. Robin et al.   NEURON

Insights into the role of d -amino acid oxidase mutations in amyotrophic lateral sclerosis

(2018) Aditya K. Padhi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Association between increased serum d -serine and cognitive gains induced by intensive cognitive training in schizophrenia

(2018) Rogerio Panizzutti et al.   SCHIZOPHRENIA RESEARCH

Chronic d-serine supplementation impairs insulin secretion

(2018) Lisa Suwandhi et al.   Molecular Metabolism

Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia

(2018) Ariel A. Jacobi et al.   NEUROSCIENCE LETTERS

Altered mRNA expressions for N-methyl-D-aspartate receptor-related genes in WBC of patients with major depressive disorder

(2018) Chieh-Hsin Lin et al.   JOURNAL OF AFFECTIVE DISORDERS

Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury

(2017) Enmanuel J. Perez et al.   JOURNAL OF CLINICAL INVESTIGATION

Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain

(2017) Sheu-Ran Choi et al.   JOURNAL OF PAIN

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny

(2017) M E Wimmer et al.   MOLECULAR PSYCHIATRY

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness

(2017) Thomas Papouin et al.   NEURON

Effects of pregabalin on spinal d-serine content and NMDA receptor-mediated synaptic transmission in mice with neuropathic pain

(2017) Eiko Kato et al.   NEUROSCIENCE LETTERS

Blood levels of D-amino acid oxidase vs. D-amino acids in reflecting cognitive aging

(2017) Chieh-Hsin Lin et al.   Scientific Reports

Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial

(2017) Chieh-Hsin Lin et al.   BIOLOGICAL PSYCHIATRY

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons

(2017) Nazanin Rahmani Kondori et al.   PLoS One

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

(2017) Yi-Ting Chen et al.   Scientific Reports

Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity

(2017) Silvia Sacchi et al.   Scientific Reports

Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker

(2016) Esra Soydaş Akyol et al.   ACTA NEUROPSYCHIATRICA

d-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice

(2016) Enza Palazzo et al.   AMINO ACIDS

The inverse link between genetic risk for schizophrenia and migraine through NMDA (N-methyl- D -aspartate) receptor activation via D -serine

(2016) Sandra Van der Auwera et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Do specific NMDA receptor subunits act as gateways for addictive behaviors?

(2016) F. W. Hopf   GENES BRAIN AND BEHAVIOR

Serine racemase is involved in d-aspartate biosynthesis

(2016) Tomokazu Ito et al.   JOURNAL OF BIOCHEMISTRY

Role ofd-amino acid oxidase in the production of kynurenine pathway metabolites fromd-tryptophan in mice

(2016) Francesca M. Notarangelo et al.   JOURNAL OF NEUROCHEMISTRY

Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging

(2016) D. Punzo et al.   JOURNAL OF NEUROSCIENCE

Cocaine self-administration disrupted by the N-methyl-D-aspartate receptor antagonist ketamine: a randomized, crossover trial

(2016) E Dakwar et al.   MOLECULAR PSYCHIATRY

Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System

(2016) Fernando J. Martinez et al.   NEURON

Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons

(2016) Paraskevi Krashia et al.   NEUROPHARMACOLOGY

Low d-serine levels in schizophrenia: A systematic review and meta-analysis

(2016) Seo-Eun Cho et al.   NEUROSCIENCE LETTERS

Structural basis for integration of GluD receptors within synaptic organizer complexes

(2016) Jonathan Elegheert et al.   SCIENCE

Gliogenic LTP spreads widely in nociceptive pathways

(2016) M. T. Kronschlager et al.   SCIENCE

Increased serum G72 protein levels in patients with schizophrenia: a potential candidate biomarker

(2016) Esra Soydaş Akyol et al.   ACTA NEUROPSYCHIATRICA

A Mutation inDAOAModifies the Age of Onset inPSEN1E280A Alzheimer’s Disease

(2016) Jorge I. Vélez et al.   NEURAL PLASTICITY

Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls

(2015) Erik Pålsson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Mutations inSLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination

(2015) Nadirah Damseh et al.   JOURNAL OF MEDICAL GENETICS

Identification of Novel d-Aspartate Oxidase Inhibitors by in Silico Screening and Their Functional and Structural Characterization in Vitro

(2015) Masumi Katane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Time and space profiling of NMDA receptor co-agonist functions

(2015) Jean-Pierre Mothet et al.   JOURNAL OF NEUROCHEMISTRY

Contributions of spinal d-amino acid oxidase to chronic morphine-induced hyperalgesia

(2015) Shuai Ma et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Potent anti-seizure effects of D-leucine

(2015) Adam L. Hartman et al.   NEUROBIOLOGY OF DISEASE

Alterations in the motor cortical and striatal glutamatergic system and d-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease

(2015) Anissa El Arfani et al.   NEUROCHEMISTRY INTERNATIONAL

D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats

(2015) Taban Seif et al.   NEUROPSYCHOPHARMACOLOGY

Neuropathic pain depends upon d-serine co-activation of spinal NMDA receptors in rats

(2015) Yan Lefèvre et al.   NEUROSCIENCE LETTERS

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

D-Aspartate Modulates Nociceptive-Specific Neuron Activity and Pain Threshold in Inflammatory and Neuropathic Pain Condition in Mice

(2015) Serena Boccella et al.   Biomed Research International

Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus

(2014) Matildé Le Bail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Add-on Treatment of Benzoate for Schizophrenia

(2013) Hsien-Yuan Lane et al.   JAMA Psychiatry

D-Amino acid oxidase controls motoneuron degeneration through D-serine

(2011) J. Sasabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine Racemase Deletion Protects Against Cerebral Ischemia and Excitotoxicity

(2010) A. K. Mustafa et al.   JOURNAL OF NEUROSCIENCE