NLRP12 drives PANoptosis in response to heme

NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

(2023) Balamurugan Sundaram et al.   CELL

NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis

(2023) Diogo Garcia Valadares et al.   iScience

ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

(2022) Rajendra Karki et al.   Science Immunology

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

(2021) Rajendra Karki et al.   Cell Reports

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection

(2018) Teneema Kuriakose et al.   JOURNAL OF IMMUNOLOGY

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL