An overview on androgen-mediated actions in skeletal muscle and adipose tissue

Does vitamin D affect strength and speed characteristics and testosterone concentration in elite young track and field athletes in the North European summer?

(2023) Eduard Bezuglov et al.   Nutrition Journal

Testosterone treatment combined with exercise to improve muscle strength, physical function and quality of life in men affected by inclusion body myositis: A randomised, double-blind, placebo-controlled, crossover trial

(2023) Sophia G. Connor et al.   PLoS One

Androgen receptor coordinates muscle metabolic and contractile functions

(2023) Kamar Ghaibour et al.   Journal of Cachexia Sarcopenia and Muscle

TMEM8C-mediated fusion is regionalized and regulated by NOTCH signalling during foetal myogenesis

(2022) Joana Esteves de Lima et al.   DEVELOPMENT

The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments

(2022) Varun S. Venkatesh et al.   Obesity Reviews

Increased Adipose Tissue Indices of Androgen Catabolism and Aromatization in Women With Metabolic Dysfunction

(2022) Giada Ostinelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Notch signaling network in muscle stem cells during development, homeostasis, and disease

(2022) Stamatia Gioftsidi et al.   Skeletal Muscle

Adipose Tissue Remodeling in Pathophysiology

(2022) Christopher Auger et al.   Annual Review of Pathology-Mechanisms of Disease

Androgen receptor suppresses β-adrenoceptor-mediated CREB activation and thermogenesis in brown adipose tissue of male mice

(2022) Naoki Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diagnostic accuracy of linked administrative data for dementia diagnosis in community-dwelling older men in Australia

(2022) Eric P. F. Chow et al.   BMC Geriatrics

Exercise mimetics and JAK inhibition attenuate IFN-γ–induced wasting in engineered human skeletal muscle

(2021) Zhaowei Chen et al.   Science Advances

Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4

(2021) Iori Sakakibara et al.   iScience

An RNAi screening of clinically relevant transcription factors regulating human adipogenesis and adipocyte metabolism

(2021) Christel Björk et al.   ENDOCRINOLOGY

Myod1 and GR coordinate myofiber-specific transcriptional enhancers

(2021) Daniela Rovito et al.   NUCLEIC ACIDS RESEARCH

Energy Metabolism Design of the Striated Muscle Cell

(2021) Brian Glancy et al.   PHYSIOLOGICAL REVIEWS

Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk

(2021) Kasiphak Kaikaew et al.   Frontiers in Endocrinology

Androgen receptor regulates the proliferation of myoblasts under appropriate or excessive stretch through IGF-1 receptor mediated p38 and ERK1/2 pathways

(2021) Shaoting Fu et al.   Nutrition & Metabolism

The role of androgens in women's health and wellbeing

(2021) Vittorio E. Bianchi et al.   PHARMACOLOGICAL RESEARCH

Lower testosterone levels predict increasing severity and worse outcomes of hepatitis B virus-related acute-on-chronic liver failure in males

(2021) Yandi Huang et al.   BMC GASTROENTEROLOGY

Testosterone reduces metabolic brown fat activity in male mice

(2021) Marta Lantero Rodriguez et al.   JOURNAL OF ENDOCRINOLOGY

Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty

(2021) Yang Xu et al.   PLoS One

Testosterone improves muscle function of the extensor digitorum longus in rats with sepsis

(2020) Jinlong Wang et al.   BIOSCIENCE REPORTS

Relationships between plasma lipidomic profiles and brown adipose tissue density in humans

(2020) Sayuri Fuse et al.   INTERNATIONAL JOURNAL OF OBESITY

Metabolic Dysfunction in Polycystic Ovary Syndrome: Pathogenic Role of Androgen Excess and Potential Therapeutic Strategies

(2020) Miguel A. Sanchez-Garrido et al.   Molecular Metabolism

Polyglutamine-Expanded Androgen Receptor Alteration of Skeletal Muscle Homeostasis and Myonuclear Aggregation Are Affected by Sex, Age and Muscle Metabolism

(2020) Mathilde Chivet et al.   Cells

The French national protocol for Kennedy’s disease (SBMA): consensus diagnostic and management recommendations

(2020) Pierre-François Pradat et al.   Orphanet Journal of Rare Diseases

Effect of testosterone supplementation on sarcopenic components in middle-aged and elderly men: A systematic review and meta-analysis

(2020) Suena Medeiros Parahiba et al.   EXPERIMENTAL GERONTOLOGY

Comparisons of Muscle Quality and Muscle Growth Factor Between Sarcopenic and Non-Sarcopenic Older Women

(2020) Myong-Won Seo et al.   International Journal of Environmental Research and Public Health

Testosterone metabolites differentially regulate obesogenesis and fat distribution

(2020) Zachary L. Sebo et al.   Molecular Metabolism

Low muscle mass and strength in pediatrics patients: Why should we care?

(2019) Camila E. Orsso et al.   CLINICAL NUTRITION

The androgen receptor in the hypothalamus positively regulates hind-limb muscle mass and voluntary physical activity in adult male mice

(2019) Michele V. Clarke et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The endocrine function of adipose tissues in health and cardiometabolic disease

(2019) Ludger Scheja et al.   Nature Reviews Endocrinology

A placebo-controlled randomized study with testosterone in Klinefelter syndrome: beneficial effects on body composition

(2019) Christian Høst et al.   Endocrine Connections

Role of androgens in energy metabolism affecting on body composition, metabolic syndrome, type 2 diabetes, cardiovascular disease, and longevity: lessons from a meta-analysis and rodent studies

(2018) Naoki Harada   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society* Clinical Practice Guideline

(2018) Shalender Bhasin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Kennedy’s disease (spinal and bulbar muscular atrophy): a clinically oriented review of a rare disease

(2018) Marianthi Breza et al.   JOURNAL OF NEUROLOGY

Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome

(2018) Bárbara Echiburú et al.   STEROIDS

Testosterone and Sarcopenia

(2018) Myung Jun Shin et al.   World Journal of Mens Health

Large divergence in testosterone concentrations between men and women: Frame of reference for elite athletes in sex-specific competition in sports, a narrative review

(2018) Richard V. Clark et al.   CLINICAL ENDOCRINOLOGY

Androgens in Women: Androgen mediated skin disease and patient evaluation (Part I)

(2018) Amanda Bienenfeld et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The androgen receptor is required for maintenance of bone mass in adult male mice

(2018) Jianyao Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice

(2017) Rachel A Davey et al.   ENDOCRINOLOGY

Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy

(2017) Suriyan Ponnusamy et al.   HUMAN MOLECULAR GENETICS

Combined androgen excess and Western-style diet accelerates adipose tissue dysfunction in young adult, female nonhuman primates

(2017) Oleg Varlamov et al.   HUMAN REPRODUCTION

Castration alters protein balance after high-frequency muscle contraction

(2017) Jennifer L. Steiner et al.   JOURNAL OF APPLIED PHYSIOLOGY

Roles of Notch1 Signaling in Regulating Satellite Cell Fates Choices and Postnatal Skeletal Myogenesis

(2017) Tizhong Shan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Developmental Programming: Impact of Prenatal Testosterone Excess on Steroidal Machinery and Cell Differentiation Markers in Visceral Adipocytes of Female Sheep

(2017) Muraly Puttabyatappa et al.   Reproductive Sciences

The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration

(2017) J. Manuel Hernández-Hernández et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle

(2016) V. J. Dalbo et al.   ANDROLOGIA

Androgen Deficiency Exacerbates High-Fat Diet-Induced Metabolic Alterations in Male Mice

(2016) Vanessa Dubois et al.   ENDOCRINOLOGY

Sex hormones establish a reserve pool of adult muscle stem cells

(2016) Ji-Hoon Kim et al.   NATURE CELL BIOLOGY

Satellite Cells in Muscular Dystrophy – Lost in Polarity

(2016) Natasha C. Chang et al.   TRENDS IN MOLECULAR MEDICINE

Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing

(2016) Elisa Giorgetti et al.   Cell Reports

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors 

(2015) David C. Hughes et al.   BIOGERONTOLOGY

The association of obesity with sex hormone-binding globulin is stronger than the association with ageing - implications for the interpretation of total testosterone measurements

(2015) Lori A. Cooper et al.   CLINICAL ENDOCRINOLOGY

Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes

(2015) Sandeep Dhindsa et al.   DIABETES CARE

The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice

(2015) Johan B. Fagman et al.   FASEB JOURNAL

Hematopoietic androgen receptor deficiency promotes visceral fat deposition in male mice without impairing glucose homeostasis

(2015) K. B. Rubinow et al.   Andrology

The activity of satellite cells and myonuclei during 8 weeks of strength training in young men with suppressed testosterone

(2014) V. J. Dalbo et al.   Acta Physiologica

Androgen effects on skeletal muscle: implications for the development and management of frailty

(2014) FrederickCW Wu et al.   ASIAN JOURNAL OF ANDROLOGY

Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model

(2014) Indranil Sinha et al.   CELL AND TISSUE RESEARCH

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

A satellite cell-specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscle

(2014) Vanessa Dubois et al.   FASEB JOURNAL

Testosterone and Its Effects on Human Male Adolescent Mood and Behavior: A Systematic Review

(2014) Sally Anne Duke et al.   JOURNAL OF ADOLESCENT HEALTH

Hyperandrogenemia in Polycystic Ovary Syndrome: Exploration of the Role of Free Testosterone and Androstenedione in Metabolic Phenotype

(2014) Elisabeth Lerchbaum et al.   PLoS One

Androgen-dependent impairment of myogenesis in spinal and bulbar muscular atrophy

(2013) Adriana Malena et al.   ACTA NEUROPATHOLOGICA

Androgen receptor agonism promotes an osteogenic gene program in preadipocytes

(2013) Sean M. Hartig et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ovarian Cycle-Specific Regulation of Adipose Tissue Lipid Storage by Testosterone in Female Nonhuman Primates

(2013) Oleg Varlamov et al.   ENDOCRINOLOGY

Reproductive Aging in Men

(2013) Shehzad Basaria   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Adipocyte and adipogenesis

(2013) Aus Tariq Ali et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Age-associated changes in hypothalamic–pituitary–testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study

(2013) E M Camacho et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Androgen Receptor CAG Repeat Length Is Associated With Body Fat and Serum SHBG in Boys: A Prospective Cohort Study

(2013) Annette Mouritsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Molecular signals governing cremaster muscle development: Clues for cryptorchidism

(2013) Maciej Szarek et al.   JOURNAL OF PEDIATRIC SURGERY

Testosterone Signals through mTOR and Androgen Receptor to Induce Muscle Hypertrophy

(2013) CARLA BASUALTO-ALARCÓN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Satellite Cells and the Muscle Stem Cell Niche

(2013) Hang Yin et al.   PHYSIOLOGICAL REVIEWS

Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation

(2013) Gregorio Chazenbalk et al.   STEROIDS

Force produced after stretch in sarcomeres and half-sarcomeres isolated from skeletal muscles

(2013) Fábio C. Minozzo et al.   Scientific Reports

Tejido adiposo: heterogeneidad celular y diversidad funcional

(2013) Montserrat Esteve Ràfols   Endocrinologia y Nutricion

Dehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor

(2012) Kei Fujioka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deletion of the Androgen Receptor in Adipose Tissue in Male Mice Elevates Retinol Binding Protein 4 and Reveals Independent Effects on Visceral Fat Mass and on Glucose Homeostasis

(2012) Kerry J. McInnes et al.   DIABETES

Androgen Effects on Adipose Tissue Architecture and Function in Nonhuman Primates

(2012) Oleg Varlamov et al.   ENDOCRINOLOGY

Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis

(2012) S.S. Lim et al.   HUMAN REPRODUCTION UPDATE

Testosterone treatment improves metabolic syndrome-induced adipose tissue derangements

(2012) Elena Maneschi et al.   JOURNAL OF ENDOCRINOLOGY

Testosterone Improves the Regeneration of Old and Young Mouse Skeletal Muscle

(2012) C. Serra et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle

(2012) James P. White et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Increased adiposity in DNA binding-dependent androgen receptor knockout male mice associated with decreased voluntary activity and not insulin resistance

(2011) Kesha Rana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions

(2011) Vanessa Dubois et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adipose Tissue Dysfunction in Polycystic Ovary Syndrome

(2011) Jennifer Villa et al.   Current Diabetes Reports

Castration-induced changes in mouse epididymal white adipose tissue

(2011) Daniel Floryk et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Androgens and obesity

(2011) Carolyn A Allan et al.   Current Opinion in Endocrinology Diabetes and Obesity

Relationships of Circulating Sex Hormone-Binding Globulin With Metabolic Traits in Humans

(2010) A. Peter et al.   DIABETES

The impact of the CAG repeat polymorphism of the androgen receptor gene on muscle and adipose tissues in 20–29-year-old Danish men: Odense Androgen Study

(2010) Torben Leo Nielsen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies

(2010) J. S. Brand et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Myocytic androgen receptor controls the strength but not the mass of limb muscles

(2010) C. Chambon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review: Testosterone and the metabolic syndrome

(2010) Vakkat Muraleedharan et al.   Therapeutic Advances in Endocrinology and Metabolism

Effects of androgens on adipocyte differentiation and adipose tissue explant metabolism in men and women

(2009) Karine Blouin et al.   CLINICAL ENDOCRINOLOGY

Mechanisms of androgenic action in adipose tissue

(2009) Alain Veilleux et al.   Clinical Lipidology

Androgen Signaling in Myocytes Contributes to the Maintenance of Muscle Mass and Fiber Type Regulation But Not to Muscle Strength or Fatigue

(2009) Jill Ophoff et al.   ENDOCRINOLOGY

Androgen-mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF1, mechano growth factor, and induction of β-catenin

(2009) Michael A Gentile et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Hyperleptinemia without Obesity in Male Mice Lacking Androgen Receptor in Adipose Tissue

(2008) I-Chen Yu et al.   ENDOCRINOLOGY

Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice

(2008) Helen E. MacLean et al.   FASEB JOURNAL

The role of Delta-like 1 shedding in muscle cell self-renewal and differentiation

(2008) D. Sun et al.   JOURNAL OF CELL SCIENCE

Hypothalamic-Pituitary-Testicular Axis Disruptions in Older Men Are Differentially Linked to Age and Modifiable Risk Factors: The European Male Aging Study

(2008) Frederick C. W. Wu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes

(2008) Vandana Gupta et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Androgens and body fat distribution

(2007) Karine Blouin et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY