An active metabolite of the anti-COVID-19 drug molnupiravir impairs mouse preimplantation embryos at clinically relevant concentrations

Ex utero monkey embryogenesis from blastocyst to early organogenesis

(2023) Yandong Gong et al.   CELL

A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response

(2023) Graham Neill et al.   Frontiers in Molecular Neuroscience

Transfer and biotransformation of the COVID-19 prodrug molnupiravir and its metabolite β-D-N4-hydroxycytidine across the blood-placenta barrier

(2023) Chun-Hao Chang et al.   EBioMedicine

Early human embryonic development: Blastocyst formation to gastrulation

(2022) Janet Rossant et al.   DEVELOPMENTAL CELL

Review on molnupiravir as a promising oral drug for the treatment of COVID-19

(2022) Elham Zarenezhad et al.   MEDICINAL CHEMISTRY RESEARCH

Toward better assessments of developmental toxicity using stem cell‐based in vitro embryogenesis models

(2022) Yusuke Marikawa   Birth Defects Research

Genotoxicity assessment of potentially mutagenic nucleoside analogues using ToxTracker®

(2022) Inger Brandsma et al.   TOXICOLOGY LETTERS

Molnupiravir and Its Antiviral Activity Against COVID-19

(2022) Lili Tian et al.   Frontiers in Immunology

Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering

(2022) Alfonso Martinez Arias et al.   DEVELOPMENTAL BIOLOGY

Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling

(2022) Vernadeth Alarcon et al.   REPRODUCTION

Remdesivir impairs mouse preimplantation embryo development at therapeutic concentrations

(2022) Yusuke Marikawa et al.   REPRODUCTIVE TOXICOLOGY

Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo

(2022) Yuexiang Li et al.   Viruses-Basel

Recent insights into mammalian natural and synthetic ex utero embryogenesis

(2022) Bernardo Oldak et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19)

(2022) Pasquale Pagliano et al.   Expert Opinion on Drug Discovery

SARS-CoV-2 RdRp uses NDPs as a substrate and is able to incorporate NHC into RNA from diphosphate form molnupiravir

(2022) Maofeng Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Impact of mono(2-ethylhexyl) phthalate (MEHP) on the development of mouse embryo in vitro

(2022) Rachel Braz Arcanjo et al.   REPRODUCTIVE TOXICOLOGY

NUPR1 interacts with eIF2α and is required for resolution of the ER stress response in pancreatic tissue

(2021) Maria Teresa Borrello et al.   FEBS Journal

C57BL/6J mouse superovulation: schedule and age optimization to increase oocyte yield and reduce animal use

(2021) Sofia Lamas et al.   ZYGOTE

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

(2021) Wendy P. Painter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Regulation of endoplasmic reticulum stress and trophectoderm lineage specification by the mevalonate pathway in the mouse preimplantation embryo

(2021) Yusuke Marikawa et al.   MOLECULAR HUMAN REPRODUCTION

Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses

(2021) Nicola Borbone et al.   MOLECULES

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

(2021) Angela Wahl et al.   NATURE

Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

(2021) Calvin J. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

(2021) Alejandro Aguilera-Castrejon et al.   NATURE

Broad-Spectrum Antiviral Strategies and Nucleoside Analogues

(2021) Robert J. Geraghty et al.   Viruses-Basel

Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites

(2021) Siennah R. Miller et al.   MOLECULAR PHARMACOLOGY

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

(2021) Florian Kabinger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Morphogenesis of the human preimplantation embryo: bringing mechanics to the clinics

(2021) Julie Firmin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sculpting with stem cells: how models of embryo development take shape

(2021) Jesse V. Veenvliet et al.   DEVELOPMENT

Molnupiravir—A Novel Oral Anti-SARS-CoV-2 Agent

(2021) Ching-Chi Lee et al.   Antibiotics-Basel

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

(2020) Timothy P. Sheahan et al.   Science Translational Medicine

Cytotoxic and estrogenic activity of chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol. Study of marine yeasts as potential toxicity indicators

(2020) Gustavo Echeverri-Jaramillo et al.   ECOTOXICOLOGY

The 3Rs and Humane Experimental Technique: Implementing Change

(2019) Hubrecht et al.   Animals

Analysis of the Potential for N4-Hydroxycytidine to Inhibit Mitochondrial Replication and Function

(2019) Zachary M. Sticher et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

(2019) Maria L. Agostini et al.   JOURNAL OF VIROLOGY

Amelioration of ochratoxin-A induced cytotoxicity by prophylactic treatment of N-Acetyl-L-Tryptophan in human embryonic kidney cells

(2019) Prerna Agarwal et al.   TOXICOLOGY

De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver

(2018) Liping Luo et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Statins inhibit blastocyst formation by preventing geranylgeranylation

(2016) Vernadeth B. Alarcon et al.   MOLECULAR HUMAN REPRODUCTION

A novel autoregulatory loop between the Gcn2-Atf4 pathway and L-Proline metabolism controls stem cell identity

(2015) C D'Aniello et al.   CELL DEATH AND DIFFERENTIATION

Induction of Herpud1 expression by ER stress is regulated by Nrf1

(2015) Daniel V. Ho et al.   FEBS LETTERS

Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro

(2014) Murat Basar et al.   FERTILITY AND STERILITY

CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade

(2014) I. N. Mungrue et al.   JOURNAL OF IMMUNOLOGY

Rho-Associated Kinase Activity Is Required for Proper Morphogenesis of the Inner Cell Mass in the Mouse Blastocyst1

(2013) Arlene May A. Laeno et al.   BIOLOGY OF REPRODUCTION

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ochratoxin A Inhibits Mouse Embryonic Development by Activating a Mitochondrion-Dependent Apoptotic Signaling Pathway

(2013) Yan-Der Hsuuw et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium

(2010) Angelos K. Sikalidis et al.   AMINO ACIDS

The principles of teratology: Are they still true?

(2010) Jan M. Friedman   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

To scale or not to scale: the principles of dose extrapolation

(2009) Vijay Sharma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intracellular redox imbalance and extracellular amino acid metabolic abnormality contribute to arsenic-induced developmental retardation in mouse preimplantation embryos

(2009) Chuanling Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

(2008) Michael L. Whitney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS