Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s Disease

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease

(2016) Federica Prati et al.   ChemMedChem

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer’s Disease

(2015) Federica Prati et al.   ACS Chemical Neuroscience

From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer’s Disease

(2015) Daniel Perez et al.   CURRENT MEDICINAL CHEMISTRY

Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation

(2015) Emiliano Peña-Altamira et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Patient-Specific Induced Pluripotent Stem Cells for Disease Modeling and Phenotypic Drug Discovery

(2015) Shibing Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

(2014) Federica Prati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

(2014) Arun K. Ghosh et al.   CHEMICAL SOCIETY REVIEWS

Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease

(2014) Natalia Guzior et al.   CURRENT MEDICINAL CHEMISTRY

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

(2014) Angel Agis-Torres et al.   Current Neuropharmacology

Dual Inhibitors of β-Amyloid Aggregation and Acetylcholinesterase as Multi-Target Anti-Alzheimer Drug Candidates

(2014) Elisabet Viayna et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Multi-target Design Strategies in the Context of Alzheimer’s Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces

(2014) Michela Rosini et al.   NEUROCHEMICAL RESEARCH

Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

(2014) F. Prati et al.   MedChemComm

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Polypharmacology in a Single Drug: Multitarget Drugs

(2013) M. L. Bolognesi   CURRENT MEDICINAL CHEMISTRY

Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease

(2013) Jing Yuan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease

(2013) Chris G. Parsons et al.   NEUROTOXICITY RESEARCH

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

(2013) Virapong Prachayasittikul et al.   Drug Design Development and Therapy

Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity

(2013) João P. Lopes et al.   Brain and Behavior

Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders

(2012) Werner J Geldenhuys et al.   Expert Opinion on Drug Discovery

Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer’s Disease

(2012) Elena Simoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

NR2B-Containing NMDA Receptors Expression and Their Relationship to Apoptosis in Hippocampus of Alzheimer’s Disease-Like Rats

(2012) Zhi’an Liu et al.   NEUROCHEMICAL RESEARCH

The role of fragment-based and computational methods in polypharmacology

(2011) Giovanni Bottegoni et al.   DRUG DISCOVERY TODAY

Combination Therapy for Alzheimerʼs Disease

(2011) Laxeshkumar Patel et al.   DRUGS & AGING

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

(2010) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bivalent β-Carbolines as Potential Multitarget Anti-Alzheimer Agents

(2010) Yvonne Rook et al.   JOURNAL OF MEDICINAL CHEMISTRY

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

(2009) Laetitia Mony et al.   BRITISH JOURNAL OF PHARMACOLOGY

Designing Multiple Ligands – Medicinal Chemistry Strategies and Challenges

(2009) Richard Morphy et al.   CURRENT PHARMACEUTICAL DESIGN

Alzheimer's disease, metal ions and metal homeostatic therapy

(2009) Paolo Zatta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

(2008) Michela Rosini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON